Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

Gene

Mgat4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4))-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein].

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-MMU-975577 N-Glycan antennae elongation
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT54 Glycosyltransferase Family 54

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC:2.4.1.145)
Alternative name(s):
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
Short name:
GnT-IVc
Short name:
N-acetylglucosaminyltransferase IVc
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc
Gene namesi
Name:Mgat4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914819 Mgat4c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini44 – 478LumenalSequence analysisAdd BLAST435

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885981 – 478Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase CAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D306
PaxDbiQ9D306
PRIDEiQ9D306

PTM databases

PhosphoSitePlusiQ9D306

Expressioni

Gene expression databases

BgeeiENSMUSG00000019888
ExpressionAtlasiQ9D306 baseline and differential
GenevisibleiQ9D306 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020039

Structurei

3D structure databases

ProteinModelPortaliQ9D306
SMRiQ9D306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 54 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II76 Eukaryota
ENOG410XPSP LUCA
GeneTreeiENSGT00550000074578
HOGENOMiHOG000070065
HOVERGENiHBG103174
InParanoidiQ9D306
KOiK13748
OMAiVMVQDIT
OrthoDBiEOG091G0K19
PhylomeDBiQ9D306
TreeFamiTF324570

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR006759 Glyco_transf_54
PANTHERiPTHR12062 PTHR12062, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFYQMKYI FQILDKMRCL RKRSTVSFLG VLVVFLLFMN LYIEDSYVLE
60 70 80 90 100
GDKQLIRETS THQLNSERYV HTFKDLSNFS GTINVTYRYL AATPLQRKRY
110 120 130 140 150
LTIGLSSVKR KKGNYLLDTI KSIFEQSSYE ELKEISVVVH LADFNSSWRD
160 170 180 190 200
AMVQDITQKF AHHIIAGRLM VIHAPEEYYP VLDGLKRNYN DPEDRVRFRS
210 220 230 240 250
KQNVDYAFLL NFCANTSDYY VMLEDDVRCS RNFLTAIKKV IASLEGTYWV
260 270 280 290 300
TLEFSKLGYI GKLYHSHDLP RLAHFLLMFY QEMPCDWLLT HFRGLLAQKN
310 320 330 340 350
VIRFKPSLFQ HMGYYSSYKG TENKLKDDDF EEESFDIPDN PPASFYTNMN
360 370 380 390 400
VFENYEASKA YSSVDEYFWG KSPSMGDTFV IVFENPITIK KIKVNTGTED
410 420 430 440 450
RQNDILQHGA LDVGEKLIFS KQIRQCDTYL RLGEFKNGYF EMSDVNQKIP
460 470
FDIHCMRICV TKTQKEWLII RSISIWTS
Length:478
Mass (Da):56,250
Last modified:June 1, 2001 - v1
Checksum:iEC8EC991A802F1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018574 mRNA Translation: BAB31286.1
AK018672 mRNA Translation: BAB31336.1
AK033482 mRNA Translation: BAC28312.1
BC046987 mRNA Translation: AAH46987.1
CCDSiCCDS24153.1
RefSeqiNP_001155840.1, NM_001162368.1
NP_001155841.1, NM_001162369.1
NP_001192027.1, NM_001205098.1
NP_080519.2, NM_026243.4
XP_006514065.1, XM_006514002.1
XP_006514066.1, XM_006514003.1
XP_006514067.1, XM_006514004.3
XP_006514068.1, XM_006514005.2
XP_011241840.1, XM_011243538.2
XP_011241841.1, XM_011243539.1
UniGeneiMm.25252
Mm.403713

Genome annotation databases

EnsembliENSMUST00000020039; ENSMUSP00000020039; ENSMUSG00000019888
ENSMUST00000120748; ENSMUSP00000114010; ENSMUSG00000019888
ENSMUST00000163753; ENSMUSP00000131551; ENSMUSG00000019888
ENSMUST00000179929; ENSMUSP00000135959; ENSMUSG00000019888
GeneIDi67569
KEGGimmu:67569
UCSCiuc007gyc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMGT4C_MOUSE
AccessioniPrimary (citable) accession number: Q9D306
Secondary accession number(s): Q9D2X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health