Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sentrin-specific protease 8

Gene

Senp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102By similarity1
Active sitei119By similarity1
Active sitei163NucleophileBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-8951664 Neddylation

Protein family/group databases

MEROPSiC48.011

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 8 (EC:3.4.22.-)
Alternative name(s):
Deneddylase-1
NEDD8-specific protease 1
Sentrin/SUMO-specific protease SENP8
Gene namesi
Name:Senp8
Synonyms:Den1, Nedp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918849 Senp8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017281 – 221Sentrin-specific protease 8Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D2Z4
PaxDbiQ9D2Z4
PRIDEiQ9D2Z4

PTM databases

PhosphoSitePlusiQ9D2Z4

Expressioni

Gene expression databases

BgeeiENSMUSG00000051705 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiMM_SENP8
ExpressionAtlasiQ9D2Z4 baseline and differential
GenevisibleiQ9D2Z4 MM

Interactioni

Protein-protein interaction databases

BioGridi214805, 1 interactor
STRINGi10090.ENSMUSP00000129441

Structurei

3D structure databases

ProteinModelPortaliQ9D2Z4
SMRiQ9D2Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 174ProteaseAdd BLAST164

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG3246 Eukaryota
ENOG4111G37 LUCA
GeneTreeiENSGT00390000014038
HOGENOMiHOG000005740
HOVERGENiHBG054214
InParanoidiQ9D2Z4
KOiK08597
PhylomeDBiQ9D2Z4
TreeFamiTF351057

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D2Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH
60 70 80 90 100
VCFISPEVTQ FIKCTSSPAE IAMFLEPLDL PHKRVVFLAI NDNSNQAAGG
110 120 130 140 150
THWSLLVYLQ DKNSFFHYDS HSRSNSIHAK QVAEKLKAFL GSKGDKLVFV
160 170 180 190 200
EEKAPAQENS YDCGMYVICN TEALCQSLFR RQPESPLQLL TPTYITKKRG
210 220
EWKDLIARLA KKNEVATEEC S
Length:221
Mass (Da):25,057
Last modified:November 28, 2002 - v2
Checksum:iAF9EB91D8A1C6F39
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRH8A0A1L1SRH8_MOUSE
Sentrin-specific protease 8
Senp8
234Annotation score:
A0A0R4J234A0A0R4J234_MOUSE
SUMO/sentrin specific peptidase 8, ...
Senp8 mCG_22641
221Annotation score:
A0A1L1ST73A0A1L1ST73_MOUSE
Sentrin-specific protease 8
Senp8
190Annotation score:

Sequence cautioni

The sequence BAB31304 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018606 mRNA Translation: BAB31304.1 Different initiation.
AK049120 mRNA Translation: BAC33554.1
BC037443 mRNA Translation: AAH37443.1
CCDSiCCDS23254.1
RefSeqiNP_001165539.1, NM_001172068.1
NP_001165540.1, NM_001172069.1
NP_001165541.1, NM_001172070.1
NP_001165542.1, NM_001172071.1
NP_082114.1, NM_027838.3
UniGeneiMm.279070

Genome annotation databases

EnsembliENSMUST00000051039; ENSMUSP00000054509; ENSMUSG00000051705
ENSMUST00000163586; ENSMUSP00000129441; ENSMUSG00000051705
ENSMUST00000177963; ENSMUSP00000137228; ENSMUSG00000051705
ENSMUST00000217093; ENSMUSP00000150601; ENSMUSG00000051705
GeneIDi71599
KEGGimmu:71599
UCSCiuc009pym.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018606 mRNA Translation: BAB31304.1 Different initiation.
AK049120 mRNA Translation: BAC33554.1
BC037443 mRNA Translation: AAH37443.1
CCDSiCCDS23254.1
RefSeqiNP_001165539.1, NM_001172068.1
NP_001165540.1, NM_001172069.1
NP_001165541.1, NM_001172070.1
NP_001165542.1, NM_001172071.1
NP_082114.1, NM_027838.3
UniGeneiMm.279070

3D structure databases

ProteinModelPortaliQ9D2Z4
SMRiQ9D2Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214805, 1 interactor
STRINGi10090.ENSMUSP00000129441

Protein family/group databases

MEROPSiC48.011

PTM databases

PhosphoSitePlusiQ9D2Z4

Proteomic databases

MaxQBiQ9D2Z4
PaxDbiQ9D2Z4
PRIDEiQ9D2Z4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051039; ENSMUSP00000054509; ENSMUSG00000051705
ENSMUST00000163586; ENSMUSP00000129441; ENSMUSG00000051705
ENSMUST00000177963; ENSMUSP00000137228; ENSMUSG00000051705
ENSMUST00000217093; ENSMUSP00000150601; ENSMUSG00000051705
GeneIDi71599
KEGGimmu:71599
UCSCiuc009pym.2 mouse

Organism-specific databases

CTDi123228
MGIiMGI:1918849 Senp8

Phylogenomic databases

eggNOGiKOG3246 Eukaryota
ENOG4111G37 LUCA
GeneTreeiENSGT00390000014038
HOGENOMiHOG000005740
HOVERGENiHBG054214
InParanoidiQ9D2Z4
KOiK08597
PhylomeDBiQ9D2Z4
TreeFamiTF351057

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:Q9D2Z4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051705 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiMM_SENP8
ExpressionAtlasiQ9D2Z4 baseline and differential
GenevisibleiQ9D2Z4 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSENP8_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Z4
Secondary accession number(s): Q543P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again