UniProtKB - Q9D2V8 (MFS10_MOUSE)
Protein
Major facilitator superfamily domain-containing protein 10
Gene
Mfsd10
Organism
Mus musculus (Mouse)
Status
Functioni
Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity).By similarity
GO - Molecular functioni
- organic anion transmembrane transporter activity Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- sodium-independent organic anion transport Source: MGI
Keywordsi
Biological process | Apoptosis, Transport |
Protein family/group databases
TCDBi | 2.A.1.2.73, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 10Alternative name(s): Tetracycline transporter-like protein |
Gene namesi | Name:Mfsd10 Synonyms:Tetran |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915544, Mfsd10 |
Subcellular locationi
Nucleus
- Nucleus inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Nucleus
- nuclear inner membrane Source: UniProtKB
Plasma Membrane
- brush border membrane Source: MGI
Other locations
- cytoplasmic vesicle membrane Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 114 – 136 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 311 – 328 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 403 – 423 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324659 | 1 – 456 | Major facilitator superfamily domain-containing protein 10Add BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9D2V8 |
MaxQBi | Q9D2V8 |
PaxDbi | Q9D2V8 |
PRIDEi | Q9D2V8 |
PTM databases
GlyGeni | Q9D2V8, 1 site |
PhosphoSitePlusi | Q9D2V8 |
SwissPalmi | Q9D2V8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001082, Expressed in embryonic stem cell and 257 other tissues |
Genevisiblei | Q9D2V8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 212789, 3 interactors |
STRINGi | 10090.ENSMUSP00000001109 |
Miscellaneous databases
RNActi | Q9D2V8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT00940000164295 |
InParanoidi | Q9D2V8 |
OMAi | LYADSFH |
OrthoDBi | 787769at2759 |
PhylomeDBi | Q9D2V8 |
TreeFami | TF314512 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
Q9D2V8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGWAGDAGCT PRPPIRPRPA SERRVIIVLF LGLLLDLLAF TLLLPLLPGL
60 70 80 90 100
LERHGREQDP LYGSWQRGVD WFASAIGMPA EKRYNSVLFG GLIGSAFSLL
110 120 130 140 150
QFFSAPLTGA ASDYLGRRPV MMLSLTGLAI SYAVWATSRS FKAFLASRVI
160 170 180 190 200
GGISKGNVNL STAIVADLGS PPTRSQGMAV IGVAFSLAFT LGPMLGAFLS
210 220 230 240 250
VEMVPWISLL FAISDMLFIF CFLPETLPQE KRASSVTLGF HTAAHLLSPL
260 270 280 290 300
ALLRFAAVTH SQDPPAEHRL RNLRRLGLVY FLYLFLFSGL EYTLSFLAHQ
310 320 330 340 350
RFQFSSLQQG KMFFFIGLTM ATIQGTYARR ISPGKEAAAV TRAMLLLVPA
360 370 380 390 400
FLLIGWAHSL PTLGLGLMLY SFAAAVVVPG LSTMVSSYGS PGQKGTIMGI
410 420 430 440 450
LRSLGALGRA LGPVVAASVY WLTGAQVCFT VCSALFLLPF LLLWKLKHPA
ETSKEE
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YYM9 | D3YYM9_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 266 | Annotation score: | ||
D3YWD5 | D3YWD5_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 278 | Annotation score: | ||
A0A0J9YVE9 | A0A0J9YVE9_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 140 | Annotation score: | ||
D6RI23 | D6RI23_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 101 | Annotation score: | ||
D3Z2Z9 | D3Z2Z9_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 58 | Annotation score: | ||
A0A0J9YUD0 | A0A0J9YUD0_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 141 | Annotation score: | ||
A0A0J9YUD3 | A0A0J9YUD3_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 113 | Annotation score: | ||
A0A0J9YTR3 | A0A0J9YTR3_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 54 | Annotation score: | ||
A0A0J9YUL6 | A0A0J9YUL6_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 130 | Annotation score: | ||
A0A0J9YV35 | A0A0J9YV35_MOUSE | Major facilitator superfamily domai... | Mfsd10 | 45 | Annotation score: |
Sequence cautioni
The sequence BAB22982 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 | G → R in BAB22982 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 340 | V → M in BAE31219 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 384 | M → L in BAE31219 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003763 mRNA Translation: BAB22982.1 Different initiation. AK018736 mRNA Translation: BAB31378.1 AK089055 mRNA Translation: BAC40724.1 AK144407 mRNA Translation: BAE25874.1 AK152438 mRNA Translation: BAE31219.1 BC023012 mRNA Translation: AAH23012.1 BC064775 mRNA Translation: AAH64775.1 |
CCDSi | CCDS19217.1 |
RefSeqi | NP_080936.1, NM_026660.2 XP_006504140.1, XM_006504077.3 XP_006504141.1, XM_006504078.3 XP_011239069.1, XM_011240767.2 XP_011239070.1, XM_011240768.2 XP_017176573.1, XM_017321084.1 |
Genome annotation databases
Ensembli | ENSMUST00000001109; ENSMUSP00000001109; ENSMUSG00000001082 ENSMUST00000114329; ENSMUSP00000109968; ENSMUSG00000001082 ENSMUST00000114331; ENSMUSP00000109970; ENSMUSG00000001082 |
GeneIDi | 68294 |
KEGGi | mmu:68294 |
UCSCi | uc008xct.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003763 mRNA Translation: BAB22982.1 Different initiation. AK018736 mRNA Translation: BAB31378.1 AK089055 mRNA Translation: BAC40724.1 AK144407 mRNA Translation: BAE25874.1 AK152438 mRNA Translation: BAE31219.1 BC023012 mRNA Translation: AAH23012.1 BC064775 mRNA Translation: AAH64775.1 |
CCDSi | CCDS19217.1 |
RefSeqi | NP_080936.1, NM_026660.2 XP_006504140.1, XM_006504077.3 XP_006504141.1, XM_006504078.3 XP_011239069.1, XM_011240767.2 XP_011239070.1, XM_011240768.2 XP_017176573.1, XM_017321084.1 |
3D structure databases
SMRi | Q9D2V8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212789, 3 interactors |
STRINGi | 10090.ENSMUSP00000001109 |
Protein family/group databases
TCDBi | 2.A.1.2.73, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q9D2V8, 1 site |
PhosphoSitePlusi | Q9D2V8 |
SwissPalmi | Q9D2V8 |
Proteomic databases
EPDi | Q9D2V8 |
MaxQBi | Q9D2V8 |
PaxDbi | Q9D2V8 |
PRIDEi | Q9D2V8 |
Protocols and materials databases
Antibodypediai | 8956, 75 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000001109; ENSMUSP00000001109; ENSMUSG00000001082 ENSMUST00000114329; ENSMUSP00000109968; ENSMUSG00000001082 ENSMUST00000114331; ENSMUSP00000109970; ENSMUSG00000001082 |
GeneIDi | 68294 |
KEGGi | mmu:68294 |
UCSCi | uc008xct.1, mouse |
Organism-specific databases
CTDi | 10227 |
MGIi | MGI:1915544, Mfsd10 |
Phylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT00940000164295 |
InParanoidi | Q9D2V8 |
OMAi | LYADSFH |
OrthoDBi | 787769at2759 |
PhylomeDBi | Q9D2V8 |
TreeFami | TF314512 |
Miscellaneous databases
BioGRID-ORCSi | 68294, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mfsd10, mouse |
PROi | PR:Q9D2V8 |
RNActi | Q9D2V8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001082, Expressed in embryonic stem cell and 257 other tissues |
Genevisiblei | Q9D2V8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFS10_MOUSE | |
Accessioni | Q9D2V8Primary (citable) accession number: Q9D2V8 Secondary accession number(s): Q3U800, Q3UN73, Q9D1A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families