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Protein

Protein AAR2 homolog

Gene

Aar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • spliceosomal tri-snRNP complex assembly Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AAR2 homolog
Alternative name(s):
AAR2 splicing factor homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aar2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1915545 Aar2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097071 – 384Protein AAR2 homologAdd BLAST384

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9D2V5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9D2V5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D2V5

PRoteomics IDEntifications database

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PRIDEi
Q9D2V5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9D2V5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D2V5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027628 Expressed in 232 organ(s), highest expression level in cardiac ventricle

CleanEx database of gene expression profiles

More...
CleanExi
MM_0610011L14RIK

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9D2V5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9D2V5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRPF8 (via RNase H homology domain) (By similarity). Component of a U5 snRNP complex that contains PRPF8 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029158

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9D2V5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAR2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3937 Eukaryota
ENOG410XSI4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007796

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230890

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051148

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9D2V5

KEGG Orthology (KO)

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KOi
K13205

Identification of Orthologs from Complete Genome Data

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OMAi
IPPDFFV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0H64

TreeFam database of animal gene trees

More...
TreeFami
TF315089

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13778 Aar2_C, 1 hit
cd13777 Aar2_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.550, 1 hit
2.60.34.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007946 AAR2
IPR033648 AAR2_C
IPR038514 AAR2_C_sf
IPR033647 Aar2_N
IPR038516 AAR2_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12689 PTHR12689, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05282 AAR2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D2V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSMQMDPEL AKQLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM
60 70 80 90 100
IPPGIHFLYY SSVDKANPRE VGPRMGFFLS LKQRGLTVLR WNAVQEEVDL
110 120 130 140 150
SPAPEAEVEA MRANLPDLDQ FLGPYPYATL KKWISLTNFI SEATMEKLQP
160 170 180 190 200
ESRQICAFSD VLPVLFMKHT KDRVGQNLPL CGTECRSYQE GLARLPEMRP
210 220 230 240 250
RAGTEIRFSE LPTQMFPAGA TPAEITRHSM DLSYALETVL SKQFPGNPQD
260 270 280 290 300
VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSESAMGK YHALYISLIS
310 320 330 340 350
ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV EATLRKKAEK
360 370 380
FQAHLTKKFR WDFTSEPEDC APVVVELPEG IETA
Length:384
Mass (Da):43,408
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i672FEC1DFDE3630F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZD25B7ZD25_MOUSE
Protein AAR2 homolog
Aar2 0610011L14Rik
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZD24B7ZD24_MOUSE
Protein AAR2 homolog
Aar2 0610011L14Rik
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166F → S in BAE38626 (PubMed:16141072).Curated1
Sequence conflicti166F → S in AAH19988 (PubMed:15489334).Curated1
Sequence conflicti166F → S in AAH20112 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK018741 mRNA Translation: BAB31382.1
AK166203 mRNA Translation: BAE38626.1
AK169526 mRNA Translation: BAE41210.1
AL929153 Genomic DNA Translation: CAM26035.1
CH466551 Genomic DNA Translation: EDL06199.1
BC019988 mRNA Translation: AAH19988.1
BC020112 mRNA Translation: AAH20112.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16967.1

NCBI Reference Sequences

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RefSeqi
NP_001158290.1, NM_001164818.1
NP_080937.3, NM_026661.4
XP_006500160.1, XM_006500097.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.253648

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029158; ENSMUSP00000029158; ENSMUSG00000027628
ENSMUST00000109570; ENSMUSP00000105198; ENSMUSG00000027628

Database of genes from NCBI RefSeq genomes

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GeneIDi
68295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68295

UCSC genome browser

More...
UCSCi
uc008nnp.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018741 mRNA Translation: BAB31382.1
AK166203 mRNA Translation: BAE38626.1
AK169526 mRNA Translation: BAE41210.1
AL929153 Genomic DNA Translation: CAM26035.1
CH466551 Genomic DNA Translation: EDL06199.1
BC019988 mRNA Translation: AAH19988.1
BC020112 mRNA Translation: AAH20112.1
CCDSiCCDS16967.1
RefSeqiNP_001158290.1, NM_001164818.1
NP_080937.3, NM_026661.4
XP_006500160.1, XM_006500097.3
UniGeneiMm.253648

3D structure databases

ProteinModelPortaliQ9D2V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029158

PTM databases

iPTMnetiQ9D2V5
PhosphoSitePlusiQ9D2V5

Proteomic databases

EPDiQ9D2V5
MaxQBiQ9D2V5
PaxDbiQ9D2V5
PRIDEiQ9D2V5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029158; ENSMUSP00000029158; ENSMUSG00000027628
ENSMUST00000109570; ENSMUSP00000105198; ENSMUSG00000027628
GeneIDi68295
KEGGimmu:68295
UCSCiuc008nnp.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25980
MGIiMGI:1915545 Aar2

Phylogenomic databases

eggNOGiKOG3937 Eukaryota
ENOG410XSI4 LUCA
GeneTreeiENSGT00390000007796
HOGENOMiHOG000230890
HOVERGENiHBG051148
InParanoidiQ9D2V5
KOiK13205
OMAiIPPDFFV
OrthoDBiEOG091G0H64
TreeFamiTF315089

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aar2 mouse

Protein Ontology

More...
PROi
PR:Q9D2V5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027628 Expressed in 232 organ(s), highest expression level in cardiac ventricle
CleanExiMM_0610011L14RIK
ExpressionAtlasiQ9D2V5 baseline and differential
GenevisibleiQ9D2V5 MM

Family and domain databases

CDDicd13778 Aar2_C, 1 hit
cd13777 Aar2_N, 1 hit
Gene3Di1.25.40.550, 1 hit
2.60.34.20, 1 hit
InterProiView protein in InterPro
IPR007946 AAR2
IPR033648 AAR2_C
IPR038514 AAR2_C_sf
IPR033647 Aar2_N
IPR038516 AAR2_N_sf
PANTHERiPTHR12689 PTHR12689, 1 hit
PfamiView protein in Pfam
PF05282 AAR2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D2V5
Secondary accession number(s): Q3TEN8, Q3TM16, Q8VBU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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