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Entry version 143 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Acetoacetyl-CoA synthetase

Gene

Aacs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-77111 Synthesis of Ketone Bodies

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetoacetyl-CoA synthetase (EC:6.2.1.16)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aacs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926144 Aacs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157861 – 672Acetoacetyl-CoA synthetaseAdd BLAST672

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9D2R0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9D2R0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9D2R0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D2R0

PeptideAtlas

More...
PeptideAtlasi
Q9D2R0

PRoteomics IDEntifications database

More...
PRIDEi
Q9D2R0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D2R0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D2R0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9D2R0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029482 Expressed in 270 organ(s), highest expression level in brown adipose tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D2R0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219689, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9D2R0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9D2R0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031445

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9D2R0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1175 Eukaryota
COG0365 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000229992

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D2R0

KEGG Orthology (KO)

More...
KOi
K01907

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWYSSTG

Database of Orthologous Groups

More...
OrthoDBi
899666at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D2R0

TreeFam database of animal gene trees

More...
TreeFami
TF354241

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005914 Acac_CoA_synth
IPR032387 ACAS_N
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01217 ac_ac_CoA_syn, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9D2R0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLARLERE EIMECQVMWE PDSKKDTQMD RFRAAVGTAC GLALGNYNDL
60 70 80 90 100
YHWSVRSYMD FWAEFWKFSG IVYSRMYDEV VDTSKGIADV PEWFRGSRLN
110 120 130 140 150
YAENLLRHKE NDRVALYVAR EGREEIVKVT FEELRQQVAL FAAAMRKMGV
160 170 180 190 200
KKGDRVVGYL PNSAHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRFSQIQ
210 220 230 240 250
PKLIFSVEAV VYNGKEHGHL EKLQRVVKGL PDLQRVVLIP YVLPREKIDI
260 270 280 290 300
SKIPNSVFLD DFLASGTGAQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
310 320 330 340 350
VHSAGGTLIQ HLKEHMLHGN MTSSDILLYY TTVGWMMWNW MVSALATGAS
360 370 380 390 400
LVLYDGSPLV PTPNVLWDLV DRIGITILGT GAKWLSVLEE KDMKPVETHN
410 420 430 440 450
LHTLHTILST GSPLKAQSYE YVYRCIKSSV LLGSISGGTD IISCFMGQNS
460 470 480 490 500
SIPVYKGEIQ ARNLGMAVEA WDEEGKAVWG ASGELVCTKP IPCQPTHFWN
510 520 530 540 550
DENGSKYRKA YFSKFPGVWA HGDYCRINPK TGGIIMLGRS DGTLNPNGVR
560 570 580 590 600
FGSSEIYNIV EAFDEVEDSL CVPQYNRDGE ERVVLFLKMA SGHTFQPDLV
610 620 630 640 650
KRIRDAIRLG LSARHVPSLI LETRGIPYTL NGKKVEVAVK QVMAGRTVEH
660 670
RGAFSNPETL DLYRDIPELQ DF
Length:672
Mass (Da):75,200
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i547E7F9B14C8BF7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti260 – 261DD → EY in BAF44057 (Ref. 1) Curated2
Sequence conflicti401L → P in BAF44057 (Ref. 1) Curated1
Sequence conflicti427K → T in BAF44057 (Ref. 1) Curated1
Sequence conflicti515F → S in BAE29423 (PubMed:16141072).Curated1
Sequence conflicti649E → G in BAE41938 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB054122 mRNA Translation: BAF44057.1
AB056114 mRNA Translation: BAB63403.1
AK019063 mRNA Translation: BAB31530.1
AK034184 mRNA Translation: BAC28621.1
AK043848 mRNA Translation: BAC31680.1
AK044017 mRNA Translation: BAC31740.1
AK147189 mRNA Translation: BAE27749.1
AK150266 mRNA Translation: BAE29423.1
AK165418 mRNA Translation: BAE38173.1
AK165457 mRNA Translation: BAE38197.1
AK170120 mRNA Translation: BAE41577.1
AK170653 mRNA Translation: BAE41938.1
AK170856 mRNA Translation: BAE42076.1
BC026817 mRNA Translation: AAH26817.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19687.1

NCBI Reference Sequences

More...
RefSeqi
NP_084486.1, NM_030210.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000031445; ENSMUSP00000031445; ENSMUSG00000029482

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:78894

UCSC genome browser

More...
UCSCi
uc008zrs.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054122 mRNA Translation: BAF44057.1
AB056114 mRNA Translation: BAB63403.1
AK019063 mRNA Translation: BAB31530.1
AK034184 mRNA Translation: BAC28621.1
AK043848 mRNA Translation: BAC31680.1
AK044017 mRNA Translation: BAC31740.1
AK147189 mRNA Translation: BAE27749.1
AK150266 mRNA Translation: BAE29423.1
AK165418 mRNA Translation: BAE38173.1
AK165457 mRNA Translation: BAE38197.1
AK170120 mRNA Translation: BAE41577.1
AK170653 mRNA Translation: BAE41938.1
AK170856 mRNA Translation: BAE42076.1
BC026817 mRNA Translation: AAH26817.1
CCDSiCCDS19687.1
RefSeqiNP_084486.1, NM_030210.1

3D structure databases

SMRiQ9D2R0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219689, 1 interactor
IntActiQ9D2R0, 2 interactors
MINTiQ9D2R0
STRINGi10090.ENSMUSP00000031445

PTM databases

iPTMnetiQ9D2R0
PhosphoSitePlusiQ9D2R0
SwissPalmiQ9D2R0

Proteomic databases

EPDiQ9D2R0
jPOSTiQ9D2R0
MaxQBiQ9D2R0
PaxDbiQ9D2R0
PeptideAtlasiQ9D2R0
PRIDEiQ9D2R0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031445; ENSMUSP00000031445; ENSMUSG00000029482
GeneIDi78894
KEGGimmu:78894
UCSCiuc008zrs.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65985
MGIiMGI:1926144 Aacs

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00940000156044
HOGENOMiHOG000229992
InParanoidiQ9D2R0
KOiK01907
OMAiHWYSSTG
OrthoDBi899666at2759
PhylomeDBiQ9D2R0
TreeFamiTF354241

Enzyme and pathway databases

ReactomeiR-MMU-77111 Synthesis of Ketone Bodies

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9D2R0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029482 Expressed in 270 organ(s), highest expression level in brown adipose tissue
GenevisibleiQ9D2R0 MM

Family and domain databases

Gene3Di3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR005914 Acac_CoA_synth
IPR032387 ACAS_N
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
TIGRFAMsiTIGR01217 ac_ac_CoA_syn, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAACS_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D2R0
Secondary accession number(s): A1IG47, Q3TCL8, Q3UD39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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