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Protein

Protein S100-A14

Gene

S100a14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A14
Alternative name(s):
S100 calcium-binding protein A14
Short name:
S114
Gene namesi
Name:S100a14
Synonyms:Gm1020, S100a15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913416 S100a14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440221 – 104Protein S100-A14Add BLAST104

Proteomic databases

MaxQBiQ9D2Q8
PaxDbiQ9D2Q8
PeptideAtlasiQ9D2Q8
PRIDEiQ9D2Q8
TopDownProteomicsiQ9D2Q8

PTM databases

iPTMnetiQ9D2Q8
PhosphoSitePlusiQ9D2Q8

Expressioni

Gene expression databases

BgeeiENSMUSG00000042306 Expressed in 120 organ(s), highest expression level in zone of skin
CleanExiMM_S100A14
ExpressionAtlasiQ9D2Q8 baseline and differential
GenevisibleiQ9D2Q8 MM

Interactioni

Subunit structurei

Homodimer. Interacts with AGER (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9D2Q8
SMRiQ9D2Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 61EF-handAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZKB Eukaryota
ENOG4111EF5 LUCA
GeneTreeiENSGT00530000063972
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiQ9D2Q8
OMAiPNNCGLE
OrthoDBiEOG091G0YGX
PhylomeDBiQ9D2Q8

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028493 S100A14
PANTHERiPTHR11639:SF4 PTHR11639:SF4, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D2Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQCRSANAE DAQEFSDVER AIETLIKNFH KYSVAGKKET LTPAELRDLV
60 70 80 90 100
TQQLPHLMPS NCGLEEKIAN LGNCNDSKLE FGSFWELIGE AAKSVKMERP

VTRS
Length:104
Mass (Da):11,599
Last modified:June 1, 2001 - v1
Checksum:i5CC04EFD2E82AAFC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q2K8E9Q2K8_MOUSE
Protein S100-A14
S100a14
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100P → L in BAB22927 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003669 mRNA Translation: BAB22927.1
AK019075 mRNA Translation: BAB31533.1
BC025607 mRNA Translation: AAH25607.1
CCDSiCCDS17535.1
RefSeqiNP_001156997.1, NM_001163525.2
NP_001156998.1, NM_001163526.2
NP_079669.2, NM_025393.4
UniGeneiMm.24006

Genome annotation databases

EnsembliENSMUST00000167598; ENSMUSP00000126821; ENSMUSG00000042306
ENSMUST00000199538; ENSMUSP00000142428; ENSMUSG00000042306
GeneIDi66166
KEGGimmu:66166
UCSCiuc008qcv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003669 mRNA Translation: BAB22927.1
AK019075 mRNA Translation: BAB31533.1
BC025607 mRNA Translation: AAH25607.1
CCDSiCCDS17535.1
RefSeqiNP_001156997.1, NM_001163525.2
NP_001156998.1, NM_001163526.2
NP_079669.2, NM_025393.4
UniGeneiMm.24006

3D structure databases

ProteinModelPortaliQ9D2Q8
SMRiQ9D2Q8
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9D2Q8
PhosphoSitePlusiQ9D2Q8

Proteomic databases

MaxQBiQ9D2Q8
PaxDbiQ9D2Q8
PeptideAtlasiQ9D2Q8
PRIDEiQ9D2Q8
TopDownProteomicsiQ9D2Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167598; ENSMUSP00000126821; ENSMUSG00000042306
ENSMUST00000199538; ENSMUSP00000142428; ENSMUSG00000042306
GeneIDi66166
KEGGimmu:66166
UCSCiuc008qcv.2 mouse

Organism-specific databases

CTDi57402
MGIiMGI:1913416 S100a14

Phylogenomic databases

eggNOGiENOG410IZKB Eukaryota
ENOG4111EF5 LUCA
GeneTreeiENSGT00530000063972
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiQ9D2Q8
OMAiPNNCGLE
OrthoDBiEOG091G0YGX
PhylomeDBiQ9D2Q8

Miscellaneous databases

PROiPR:Q9D2Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042306 Expressed in 120 organ(s), highest expression level in zone of skin
CleanExiMM_S100A14
ExpressionAtlasiQ9D2Q8 baseline and differential
GenevisibleiQ9D2Q8 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028493 S100A14
PANTHERiPTHR11639:SF4 PTHR11639:SF4, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10AE_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Q8
Secondary accession number(s): Q9D1D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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