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Protein

Dystrobrevin alpha

Gene

Dtna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in synapse maturation and required for normal muscle function.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin alpha
Short name:
DTN-A
Alternative name(s):
Alpha-dystrobrevin
Gene namesi
Name:Dtna
Synonyms:Dtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:106039 Dtna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800371 – 746Dystrobrevin alphaAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei666PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiQ9D2N4
PRIDEiQ9D2N4

PTM databases

iPTMnetiQ9D2N4
PhosphoSitePlusiQ9D2N4
SwissPalmiQ9D2N4

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.

Developmental stagei

Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.

Gene expression databases

BgeeiENSMUSG00000024302 Expressed in 263 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_DTNA
ExpressionAtlasiQ9D2N4 baseline and differential
GenevisibleiQ9D2N4 MM

Interactioni

Subunit structurei

Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dtnbp1Q91WZ83EBI-296019,EBI-643186

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199334, 2 interactors
CORUMiQ9D2N4
IntActiQ9D2N4, 9 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9D2N4
SMRiQ9D2N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 288Interaction with MAGEE11 PublicationAdd BLAST288
Regioni397 – 447Syntrophin-binding regionAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili458 – 557Sequence analysisAdd BLAST100

Domaini

The coiled coil domain mediates the interaction with dystrophin and utrophin.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000119237
HOVERGENiHBG005539
InParanoidiQ9D2N4
PhylomeDBiQ9D2N4

Family and domain databases

InterProiView protein in InterPro
IPR017432 Distrobrevin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF038204 Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2N4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL
60 70 80 90 100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH
110 120 130 140 150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY
160 170 180 190 200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ
210 220 230 240 250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT
310 320 330 340 350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS
360 370 380 390 400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA
410 420 430 440 450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP
460 470 480 490 500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP
510 520 530 540 550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL
560 570 580 590 600
KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG
610 620 630 640 650
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST
660 670 680 690 700
VDSEFSRPQF EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE
710 720 730 740
DGDPYTQPED GNYENESVRQ LENELQLEEY LKQKLQDEAY QVSLQG
Length:746
Mass (Da):84,067
Last modified:February 8, 2011 - v2
Checksum:i6AB7EF3B69250A09
GO
Isoform 2 (identifier: Q9D2N4-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-1, Alpha-DB1

The sequence of this isoform differs from the canonical sequence as follows:
     363-419: Missing.
     560-561: QG → R

Show »
Length:688
Mass (Da):77,733
Checksum:i82AC1104D48313EA
GO
Isoform 3 (identifier: Q9D2N4-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-2B, Alpha-DB2B

The sequence of this isoform differs from the canonical sequence as follows:
     559-570: TQGASSPRSSPS → VMHEIIPLEERT
     571-746: Missing.

Show »
Length:570
Mass (Da):65,157
Checksum:iCA135BFB7B7A3DDE
GO
Isoform 4 (identifier: Q9D2N4-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-2A, Alpha-DB2A

The sequence of this isoform differs from the canonical sequence as follows:
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:567
Mass (Da):64,763
Checksum:i73C843F6C9E27940
GO
Isoform 5 (identifier: Q9D2N4-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:374
Mass (Da):42,380
Checksum:i286DE068A207D235
GO
Isoform 6 (identifier: Q9D2N4-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:371
Mass (Da):41,977
Checksum:i444BB5947F3D5DD3
GO
Isoform 7 (identifier: Q9D2N4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     363-419: Missing.
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:513
Mass (Da):58,860
Checksum:iEA3913DA5334D7E1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CFR5Q8CFR5_MOUSE
Dystrobrevin
Dtna
682Annotation score:
A0A1Y7VL34A0A1Y7VL34_MOUSE
Dystrobrevin
Dtna mCG_140483
746Annotation score:
A0A1Y7VJN9A0A1Y7VJN9_MOUSE
Dystrobrevin
Dtna
567Annotation score:
A0A1Y7VLZ6A0A1Y7VLZ6_MOUSE
Dystrobrevin alpha
Dtna
73Annotation score:
A0A1Y7VK79A0A1Y7VK79_MOUSE
Dystrobrevin alpha
Dtna
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241V → L in CAA64519 (PubMed:8631824).Curated1
Sequence conflicti251M → I in BAB31746 (PubMed:16141072).Curated1
Sequence conflicti259Q → P in AAD33915 (PubMed:10570976).Curated1
Sequence conflicti416D → N in AAD33915 (PubMed:10570976).Curated1
Sequence conflicti416D → N in AAD33914 (PubMed:10570976).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004214334V → VDTW in isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_004215363 – 419Missing in isoform 2 and isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_004216364 – 371PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6. 2 Publications8
Alternative sequenceiVSP_004217372 – 746Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST375
Alternative sequenceiVSP_004221559 – 570TQGAS…RSSPS → VMHEIIPLEERT in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_004218559 – 567TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7. 2 Publications9
Alternative sequenceiVSP_004220560 – 561QG → R in isoform 2. 1 Publication2
Alternative sequenceiVSP_004219568 – 746Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST179
Alternative sequenceiVSP_004222571 – 746Missing in isoform 3. 1 PublicationAdd BLAST176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95226 mRNA Translation: CAA64518.1
X95227 mRNA Translation: CAA64519.1
Z79787
, Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA Translation: CAB02145.1
AJ009669 mRNA Translation: CAA08770.1
AF143544 mRNA Translation: AAD33915.1
AF143543 mRNA Translation: AAD33914.1
AF143542 mRNA Translation: AAD33913.1
AK019477 mRNA Translation: BAB31746.1
CCDSiCCDS29094.1 [Q9D2N4-6]
RefSeqiNP_001272736.1, NM_001285807.1
NP_001272739.1, NM_001285810.1
NP_001272746.1, NM_001285817.1
NP_034217.2, NM_010087.4 [Q9D2N4-6]
XP_017173306.1, XM_017317817.1
XP_017173308.1, XM_017317819.1 [Q9D2N4-7]
XP_017173310.1, XM_017317821.1 [Q9D2N4-7]
XP_017173311.1, XM_017317822.1 [Q9D2N4-7]
XP_017173312.1, XM_017317823.1 [Q9D2N4-7]
XP_017173313.1, XM_017317824.1 [Q9D2N4-7]
XP_017173315.1, XM_017317826.1 [Q9D2N4-5]
UniGeneiMm.484047
Mm.94371

Genome annotation databases

EnsembliENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]
GeneIDi13527
KEGGimmu:13527
UCSCiuc008efs.2 mouse [Q9D2N4-7]
uc008efv.2 mouse [Q9D2N4-4]
uc008efw.2 mouse [Q9D2N4-3]
uc008efx.2 mouse [Q9D2N4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95226 mRNA Translation: CAA64518.1
X95227 mRNA Translation: CAA64519.1
Z79787
, Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA Translation: CAB02145.1
AJ009669 mRNA Translation: CAA08770.1
AF143544 mRNA Translation: AAD33915.1
AF143543 mRNA Translation: AAD33914.1
AF143542 mRNA Translation: AAD33913.1
AK019477 mRNA Translation: BAB31746.1
CCDSiCCDS29094.1 [Q9D2N4-6]
RefSeqiNP_001272736.1, NM_001285807.1
NP_001272739.1, NM_001285810.1
NP_001272746.1, NM_001285817.1
NP_034217.2, NM_010087.4 [Q9D2N4-6]
XP_017173306.1, XM_017317817.1
XP_017173308.1, XM_017317819.1 [Q9D2N4-7]
XP_017173310.1, XM_017317821.1 [Q9D2N4-7]
XP_017173311.1, XM_017317822.1 [Q9D2N4-7]
XP_017173312.1, XM_017317823.1 [Q9D2N4-7]
XP_017173313.1, XM_017317824.1 [Q9D2N4-7]
XP_017173315.1, XM_017317826.1 [Q9D2N4-5]
UniGeneiMm.484047
Mm.94371

3D structure databases

ProteinModelPortaliQ9D2N4
SMRiQ9D2N4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199334, 2 interactors
CORUMiQ9D2N4
IntActiQ9D2N4, 9 interactors

PTM databases

iPTMnetiQ9D2N4
PhosphoSitePlusiQ9D2N4
SwissPalmiQ9D2N4

Proteomic databases

PeptideAtlasiQ9D2N4
PRIDEiQ9D2N4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]
GeneIDi13527
KEGGimmu:13527
UCSCiuc008efs.2 mouse [Q9D2N4-7]
uc008efv.2 mouse [Q9D2N4-4]
uc008efw.2 mouse [Q9D2N4-3]
uc008efx.2 mouse [Q9D2N4-1]

Organism-specific databases

CTDi1837
MGIiMGI:106039 Dtna

Phylogenomic databases

GeneTreeiENSGT00760000119237
HOVERGENiHBG005539
InParanoidiQ9D2N4
PhylomeDBiQ9D2N4

Miscellaneous databases

PROiPR:Q9D2N4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024302 Expressed in 263 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_DTNA
ExpressionAtlasiQ9D2N4 baseline and differential
GenevisibleiQ9D2N4 MM

Family and domain databases

InterProiView protein in InterPro
IPR017432 Distrobrevin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF038204 Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDTNA_MOUSE
AccessioniPrimary (citable) accession number: Q9D2N4
Secondary accession number(s): P97319
, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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