Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9D2N4 (DTNA_MOUSE)

Entry version 157 (29 Sep 2021)
Sequence version 2 (08 Feb 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Dystrobrevin alpha

Gene

Dtna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in synapse maturation and required for normal muscle function.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi243Zinc 1PROSITE-ProRule annotation1
Metal bindingi246Zinc 1PROSITE-ProRule annotation1
Metal bindingi258Zinc 2PROSITE-ProRule annotation1
Metal bindingi261Zinc 2PROSITE-ProRule annotation1
Metal bindingi267Zinc 1PROSITE-ProRule annotation1
Metal bindingi270Zinc 1PROSITE-ProRule annotation1
Metal bindingi280Zinc 2PROSITE-ProRule annotation1
Metal bindingi284Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri238 – 294ZZ-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • synaptic signaling Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrobrevin alpha
Short name:
DTN-A
Alternative name(s):
Alpha-dystrobrevin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dtna
Synonyms:Dtn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:106039, Dtna

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000024302

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000800371 – 746Dystrobrevin alphaAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei666PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q9D2N4

PRoteomics IDEntifications database

More...PRIDEi		Q9D2N4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		277515 [Q9D2N4-1]
277516 [Q9D2N4-2]
277517 [Q9D2N4-3]
277518 [Q9D2N4-4]
277519 [Q9D2N4-5]
277520 [Q9D2N4-6]
277521 [Q9D2N4-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9D2N4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9D2N4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9D2N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024302, Expressed in saccule of membranous labyrinth and 288 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9D2N4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9D2N4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1.

Interacts with MAGEE1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199334, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9D2N4

Protein interaction database and analysis system

More...IntActi		Q9D2N4, 19 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000111498

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9D2N4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9D2N4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 288Interaction with MAGEE11 PublicationAdd BLAST288
Regioni397 – 447Syntrophin-binding regionAdd BLAST51
Regioni555 – 577DisorderedSequence analysisAdd BLAST23
Regioni646 – 667DisorderedSequence analysisAdd BLAST22
Regioni684 – 721DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili458 – 557Sequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi557 – 574Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil domain mediates the interaction with dystrophin and utrophin.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dystrophin family. Dystrobrevin subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 294ZZ-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4301, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001187_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9D2N4

Database of Orthologous Groups

More...OrthoDBi		699158at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9D2N4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017432, Distrobrevin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00569, ZZ, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038204, Distrobrevin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2N4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370        380        390        400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA 
       410        420        430        440        450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP 
       460        470        480        490        500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP 
       510        520        530        540        550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL 
       560        570        580        590        600
KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG 
       610        620        630        640        650
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST 
       660        670        680        690        700
VDSEFSRPQF EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE 
       710        720        730        740 
DGDPYTQPED GNYENESVRQ LENELQLEEY LKQKLQDEAY QVSLQG
Length:746
Mass (Da):84,067
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AB7EF3B69250A09
GO
Isoform 2 (identifier: Q9D2N4-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-1, Alpha-DB1

The sequence of this isoform differs from the canonical sequence as follows:
     363-419: Missing.
     560-561: QG → R

Show »
Length:688
Mass (Da):77,733
Checksum:i82AC1104D48313EA
GO
Isoform 3 (identifier: Q9D2N4-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-2B, Alpha-DB2B

The sequence of this isoform differs from the canonical sequence as follows:
     559-570: TQGASSPRSSPS → VMHEIIPLEERT
     571-746: Missing.

Show »
Length:570
Mass (Da):65,157
Checksum:iCA135BFB7B7A3DDE
GO
Isoform 4 (identifier: Q9D2N4-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-2A, Alpha-DB2A

The sequence of this isoform differs from the canonical sequence as follows:
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:567
Mass (Da):64,763
Checksum:i73C843F6C9E27940
GO
Isoform 5 (identifier: Q9D2N4-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:374
Mass (Da):42,380
Checksum:i286DE068A207D235
GO
Isoform 6 (identifier: Q9D2N4-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

Show »
Length:371
Mass (Da):41,977
Checksum:i444BB5947F3D5DD3
GO
Isoform 7 (identifier: Q9D2N4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     363-419: Missing.
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

Show »
Length:513
Mass (Da):58,860
Checksum:iEA3913DA5334D7E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VL34A0A1Y7VL34_MOUSE
Dystrobrevin
Dtna
746Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CFR5Q8CFR5_MOUSE
Dystrobrevin
Dtna
682Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJN9A0A1Y7VJN9_MOUSE
Dystrobrevin
Dtna
567Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VLZ6A0A1Y7VLZ6_MOUSE
Dystrobrevin alpha
Dtna
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VK79A0A1Y7VK79_MOUSE
Dystrobrevin alpha
Dtna
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241V → L in CAA64519 (PubMed:8631824).Curated1
Sequence conflicti251M → I in BAB31746 (PubMed:16141072).Curated1
Sequence conflicti259Q → P in AAD33915 (PubMed:10570976).Curated1
Sequence conflicti416D → N in AAD33915 (PubMed:10570976).Curated1
Sequence conflicti416D → N in AAD33914 (PubMed:10570976).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004214334V → VDTW in isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_004215363 – 419Missing in isoform 2 and isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_004216364 – 371PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6. 2 Publications8
Alternative sequenceiVSP_004217372 – 746Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST375
Alternative sequenceiVSP_004221559 – 570TQGAS…RSSPS → VMHEIIPLEERT in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_004218559 – 567TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7. 2 Publications9
Alternative sequenceiVSP_004220560 – 561QG → R in isoform 2. 1 Publication2
Alternative sequenceiVSP_004219568 – 746Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST179
Alternative sequenceiVSP_004222571 – 746Missing in isoform 3. 1 PublicationAdd BLAST176

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X95226 mRNA Translation: CAA64518.1
X95227 mRNA Translation: CAA64519.1
Z79787 Z79797 Genomic DNA Translation: CAB02145.1
AJ009669 mRNA Translation: CAA08770.1
AF143544 mRNA Translation: AAD33915.1
AF143543 mRNA Translation: AAD33914.1
AF143542 mRNA Translation: AAD33913.1
AK019477 mRNA Translation: BAB31746.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29094.1 [Q9D2N4-6]
CCDS89200.1 [Q9D2N4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001272736.1, NM_001285807.1
NP_001272739.1, NM_001285810.1
NP_001272746.1, NM_001285817.1
NP_034217.2, NM_010087.4 [Q9D2N4-6]
XP_017173306.1, XM_017317817.1
XP_017173308.1, XM_017317819.1
XP_017173310.1, XM_017317821.1
XP_017173311.1, XM_017317822.1
XP_017173312.1, XM_017317823.1
XP_017173313.1, XM_017317824.1
XP_017173315.1, XM_017317826.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13527

UCSC genome browser

More...UCSCi		uc008efs.2, mouse [Q9D2N4-7]
uc008efv.2, mouse [Q9D2N4-4]
uc008efw.2, mouse [Q9D2N4-3]
uc008efx.2, mouse [Q9D2N4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95226 mRNA Translation: CAA64518.1
X95227 mRNA Translation: CAA64519.1
Z79787 Z79797 Genomic DNA Translation: CAB02145.1
AJ009669 mRNA Translation: CAA08770.1
AF143544 mRNA Translation: AAD33915.1
AF143543 mRNA Translation: AAD33914.1
AF143542 mRNA Translation: AAD33913.1
AK019477 mRNA Translation: BAB31746.1
CCDSiCCDS29094.1 [Q9D2N4-6]
CCDS89200.1 [Q9D2N4-1]
RefSeqiNP_001272736.1, NM_001285807.1
NP_001272739.1, NM_001285810.1
NP_001272746.1, NM_001285817.1
NP_034217.2, NM_010087.4 [Q9D2N4-6]
XP_017173306.1, XM_017317817.1
XP_017173308.1, XM_017317819.1
XP_017173310.1, XM_017317821.1
XP_017173311.1, XM_017317822.1
XP_017173312.1, XM_017317823.1
XP_017173313.1, XM_017317824.1
XP_017173315.1, XM_017317826.1

3D structure databases

SMRiQ9D2N4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199334, 9 interactors
CORUMiQ9D2N4
IntActiQ9D2N4, 19 interactors
STRINGi10090.ENSMUSP00000111498

PTM databases

iPTMnetiQ9D2N4
PhosphoSitePlusiQ9D2N4
SwissPalmiQ9D2N4

Proteomic databases

PeptideAtlasiQ9D2N4
PRIDEiQ9D2N4
ProteomicsDBi277515 [Q9D2N4-1]
277516 [Q9D2N4-2]
277517 [Q9D2N4-3]
277518 [Q9D2N4-4]
277519 [Q9D2N4-5]
277520 [Q9D2N4-6]
277521 [Q9D2N4-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22242, 240 antibodies

The DNASU plasmid repository

More...DNASUi		13527

Genome annotation databases

EnsembliENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]
GeneIDi13527
KEGGimmu:13527
UCSCiuc008efs.2, mouse [Q9D2N4-7]
uc008efv.2, mouse [Q9D2N4-4]
uc008efw.2, mouse [Q9D2N4-3]
uc008efx.2, mouse [Q9D2N4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1837
MGIiMGI:106039, Dtna
VEuPathDBiHostDB:ENSMUSG00000024302

Phylogenomic databases

eggNOGiKOG4301, Eukaryota
GeneTreeiENSGT00940000153897
HOGENOMiCLU_001187_2_0_1
InParanoidiQ9D2N4
OrthoDBi699158at2759
PhylomeDBiQ9D2N4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		13527, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Dtna, mouse

Protein Ontology

More...PROi		PR:Q9D2N4
RNActiQ9D2N4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024302, Expressed in saccule of membranous labyrinth and 288 other tissues
ExpressionAtlasiQ9D2N4, baseline and differential
GenevisibleiQ9D2N4, MM

Family and domain databases

Gene3Di3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR017432, Distrobrevin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00569, ZZ, 1 hit
PIRSFiPIRSF038204, Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTNA_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D2N4
Secondary accession number(s): P97319
, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 8, 2011
Last modified: September 29, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again