UniProtKB - Q9D2N4 (DTNA_MOUSE)
Dystrobrevin alpha
Dtna
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 284 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- PDZ domain binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- synaptic signaling Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Dystrobrevin alphaShort name: DTN-A Alternative name(s): Alpha-dystrobrevin |
Gene namesi | Name:Dtna Synonyms:Dtn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106039, Dtna |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
Note: In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Plasma Membrane
- dystrobrevin complex Source: UniProtKB
- extrinsic component of cytoplasmic side of plasma membrane Source: MGI
- plasma membrane Source: GO_Central
- sarcolemma Source: MGI
Other locations
- axon Source: MGI
- cell projection Source: MGI
- cytoplasm Source: MGI
- protein-containing complex Source: MGI
- synapse Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080037 | 1 – 746 | Dystrobrevin alphaAdd BLAST | 746 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 666 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PeptideAtlasi | Q9D2N4 |
PRIDEi | Q9D2N4 |
PTM databases
iPTMneti | Q9D2N4 |
PhosphoSitePlusi | Q9D2N4 |
SwissPalmi | Q9D2N4 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000024302, Expressed in saccule of membranous labyrinth and 282 other tissues |
ExpressionAtlasi | Q9D2N4, baseline and differential |
Genevisiblei | Q9D2N4, MM |
Interactioni
Subunit structurei
Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1.
Interacts with MAGEE1.
4 PublicationsBinary interactionsi
Q9D2N4
With | #Exp. | IntAct |
---|---|---|
Dtnbp1 [Q91WZ8] | 3 | EBI-296019,EBI-643186 |
GO - Molecular functioni
- PDZ domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199334, 8 interactors |
CORUMi | Q9D2N4 |
IntActi | Q9D2N4, 19 interactors |
STRINGi | 10090.ENSMUSP00000111498 |
Miscellaneous databases
RNActi | Q9D2N4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 288 | Interaction with MAGEE11 PublicationAdd BLAST | 288 | |
Regioni | 397 – 447 | Syntrophin-binding regionAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 458 – 557 | Sequence analysisAdd BLAST | 100 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 284 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4301, Eukaryota |
GeneTreei | ENSGT00940000153897 |
HOGENOMi | CLU_001187_2_0_1 |
InParanoidi | Q9D2N4 |
OrthoDBi | 699158at2759 |
PhylomeDBi | Q9D2N4 |
Family and domain databases
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017432, Distrobrevin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038204, Distrobrevin, 1 hit |
SMARTi | View protein in SMART SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL
60 70 80 90 100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH
110 120 130 140 150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY
160 170 180 190 200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ
210 220 230 240 250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT
310 320 330 340 350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS
360 370 380 390 400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA
410 420 430 440 450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP
460 470 480 490 500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP
510 520 530 540 550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL
560 570 580 590 600
KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG
610 620 630 640 650
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST
660 670 680 690 700
VDSEFSRPQF EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE
710 720 730 740
DGDPYTQPED GNYENESVRQ LENELQLEEY LKQKLQDEAY QVSLQG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8CFR5 | Q8CFR5_MOUSE | Dystrobrevin | Dtna | 682 | Annotation score: | ||
A0A1Y7VJN9 | A0A1Y7VJN9_MOUSE | Dystrobrevin | Dtna | 567 | Annotation score: | ||
A0A1Y7VL34 | A0A1Y7VL34_MOUSE | Dystrobrevin | Dtna | 746 | Annotation score: | ||
A0A1Y7VLZ6 | A0A1Y7VLZ6_MOUSE | Dystrobrevin alpha | Dtna | 73 | Annotation score: | ||
A0A1Y7VK79 | A0A1Y7VK79_MOUSE | Dystrobrevin alpha | Dtna | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | V → L in CAA64519 (PubMed:8631824).Curated | 1 | |
Sequence conflicti | 251 | M → I in BAB31746 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 259 | Q → P in AAD33915 (PubMed:10570976).Curated | 1 | |
Sequence conflicti | 416 | D → N in AAD33915 (PubMed:10570976).Curated | 1 | |
Sequence conflicti | 416 | D → N in AAD33914 (PubMed:10570976).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004214 | 334 | V → VDTW in isoform 5 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_004215 | 363 – 419 | Missing in isoform 2 and isoform 7. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_004216 | 364 – 371 | PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6. 2 Publications | 8 | |
Alternative sequenceiVSP_004217 | 372 – 746 | Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 375 | |
Alternative sequenceiVSP_004221 | 559 – 570 | TQGAS…RSSPS → VMHEIIPLEERT in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_004218 | 559 – 567 | TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7. 2 Publications | 9 | |
Alternative sequenceiVSP_004220 | 560 – 561 | QG → R in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_004219 | 568 – 746 | Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST | 179 | |
Alternative sequenceiVSP_004222 | 571 – 746 | Missing in isoform 3. 1 PublicationAdd BLAST | 176 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95226 mRNA Translation: CAA64518.1 X95227 mRNA Translation: CAA64519.1 Z79787 , Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA Translation: CAB02145.1 AJ009669 mRNA Translation: CAA08770.1 AF143544 mRNA Translation: AAD33915.1 AF143543 mRNA Translation: AAD33914.1 AF143542 mRNA Translation: AAD33913.1 AK019477 mRNA Translation: BAB31746.1 |
CCDSi | CCDS29094.1 [Q9D2N4-6] CCDS89200.1 [Q9D2N4-1] |
RefSeqi | NP_001272736.1, NM_001285807.1 NP_001272739.1, NM_001285810.1 NP_001272746.1, NM_001285817.1 NP_034217.2, NM_010087.4 [Q9D2N4-6] XP_017173306.1, XM_017317817.1 XP_017173308.1, XM_017317819.1 XP_017173310.1, XM_017317821.1 XP_017173311.1, XM_017317822.1 XP_017173312.1, XM_017317823.1 XP_017173313.1, XM_017317824.1 XP_017173315.1, XM_017317826.1 |
Genome annotation databases
Ensembli | ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6] |
GeneIDi | 13527 |
KEGGi | mmu:13527 |
UCSCi | uc008efs.2, mouse [Q9D2N4-7] uc008efv.2, mouse [Q9D2N4-4] uc008efw.2, mouse [Q9D2N4-3] uc008efx.2, mouse [Q9D2N4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95226 mRNA Translation: CAA64518.1 X95227 mRNA Translation: CAA64519.1 Z79787 , Z79788, Z79789, Z79790, Z79791, Z79792, Z79793, Z79794, Z79795, Z79796, Z79797 Genomic DNA Translation: CAB02145.1 AJ009669 mRNA Translation: CAA08770.1 AF143544 mRNA Translation: AAD33915.1 AF143543 mRNA Translation: AAD33914.1 AF143542 mRNA Translation: AAD33913.1 AK019477 mRNA Translation: BAB31746.1 |
CCDSi | CCDS29094.1 [Q9D2N4-6] CCDS89200.1 [Q9D2N4-1] |
RefSeqi | NP_001272736.1, NM_001285807.1 NP_001272739.1, NM_001285810.1 NP_001272746.1, NM_001285817.1 NP_034217.2, NM_010087.4 [Q9D2N4-6] XP_017173306.1, XM_017317817.1 XP_017173308.1, XM_017317819.1 XP_017173310.1, XM_017317821.1 XP_017173311.1, XM_017317822.1 XP_017173312.1, XM_017317823.1 XP_017173313.1, XM_017317824.1 XP_017173315.1, XM_017317826.1 |
3D structure databases
SMRi | Q9D2N4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199334, 8 interactors |
CORUMi | Q9D2N4 |
IntActi | Q9D2N4, 19 interactors |
STRINGi | 10090.ENSMUSP00000111498 |
PTM databases
iPTMneti | Q9D2N4 |
PhosphoSitePlusi | Q9D2N4 |
SwissPalmi | Q9D2N4 |
Proteomic databases
PeptideAtlasi | Q9D2N4 |
PRIDEi | Q9D2N4 |
Protocols and materials databases
Antibodypediai | 22242, 237 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6] |
GeneIDi | 13527 |
KEGGi | mmu:13527 |
UCSCi | uc008efs.2, mouse [Q9D2N4-7] uc008efv.2, mouse [Q9D2N4-4] uc008efw.2, mouse [Q9D2N4-3] uc008efx.2, mouse [Q9D2N4-1] |
Organism-specific databases
CTDi | 1837 |
MGIi | MGI:106039, Dtna |
Phylogenomic databases
eggNOGi | KOG4301, Eukaryota |
GeneTreei | ENSGT00940000153897 |
HOGENOMi | CLU_001187_2_0_1 |
InParanoidi | Q9D2N4 |
OrthoDBi | 699158at2759 |
PhylomeDBi | Q9D2N4 |
Miscellaneous databases
BioGRID-ORCSi | 13527, 0 hits in 17 CRISPR screens |
ChiTaRSi | Dtna, mouse |
PROi | PR:Q9D2N4 |
RNActi | Q9D2N4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024302, Expressed in saccule of membranous labyrinth and 282 other tissues |
ExpressionAtlasi | Q9D2N4, baseline and differential |
Genevisiblei | Q9D2N4, MM |
Family and domain databases
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017432, Distrobrevin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038204, Distrobrevin, 1 hit |
SMARTi | View protein in SMART SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DTNA_MOUSE | |
Accessioni | Q9D2N4Primary (citable) accession number: Q9D2N4 Secondary accession number(s): P97319 Q9WUM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families