Dtna

Functionⁱ

Involved in synapse maturation and required for normal muscle function.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	237 – 284	ZZ-typePROSITE-ProRule annotationAdd BLAST		48

GO - Molecular functionⁱ

PDZ domain binding Source: MGI
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dystrobrevin alpha Short name: DTN-A Alternative name(s): Alpha-dystrobrevin
Gene namesⁱ	Name:Dtna Synonyms:Dtn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:106039 Dtna

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080037	1 – 746	Dystrobrevin alphaAdd BLAST		746

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	666	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylation of isoform 2 on tyrosine kinase substrate domain present in the C-terminus.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q9D2N4
PRIDEⁱ	Q9D2N4

PTM databases

iPTMnetⁱ	Q9D2N4
PhosphoSitePlusⁱ	Q9D2N4
SwissPalmⁱ	Q9D2N4

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.

Developmental stageⁱ

Expression of alpha-dystrobrevin is up-regulated during differentiation, with isoforms 2, 5 and 6 expressed earliest and isoform 3 and 4 expressed later.

Gene expression databases

Bgeeⁱ	ENSMUSG00000024302 Expressed in 263 organ(s), highest expression level in saccule of membranous labyrinth
CleanExⁱ	MM_DTNA
ExpressionAtlasⁱ	Q9D2N4 baseline and differential
Genevisibleⁱ	Q9D2N4 MM

Interactionⁱ

Subunit structureⁱ

Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoforms 5 and 6 do not interact with syntrophin. Isoforms 3 and 4 do not interact with utrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Dtnbp1	Q91WZ8	3	EBI-296019,EBI-643186

With

Entry

#Exp.

IntAct

Notes

Dtnbp1

Q91WZ8

3

EBI-296019,EBI-643186

GO - Molecular functionⁱ

PDZ domain binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199334, 2 interactors
CORUMⁱ	Q9D2N4
IntActⁱ	Q9D2N4, 9 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D2N4
SMRⁱ	Q9D2N4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 288	Interaction with MAGEE11 PublicationAdd BLAST		288
Regionⁱ	397 – 447	Syntrophin-binding regionAdd BLAST		51

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	458 – 557	Sequence analysisAdd BLAST		100

Domainⁱ

The coiled coil domain mediates the interaction with dystrophin and utrophin.

Sequence similaritiesⁱ

Belongs to the dystrophin family. Dystrobrevin subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	237 – 284	ZZ-typePROSITE-ProRule annotationAdd BLAST		48

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119237
HOVERGENⁱ	HBG005539
InParanoidⁱ	Q9D2N4
PhylomeDBⁱ	Q9D2N4

Family and domain databases

InterProⁱ	View protein in InterPro IPR017432 Distrobrevin IPR011992 EF-hand-dom_pair IPR015153 EF-hand_dom_typ1 IPR015154 EF-hand_dom_typ2 IPR000433 Znf_ZZ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09068 EF-hand_2, 1 hit PF09069 EF-hand_3, 1 hit PF00569 ZZ, 1 hit
PIRSFⁱ	PIRSF038204 Distrobrevin, 1 hit
SMARTⁱ	View protein in SMART SM00291 ZnF_ZZ, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 2 hits
PROSITEⁱ	View protein in PROSITE PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9D2N4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370        380        390        400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA 
       410        420        430        440        450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP 
       460        470        480        490        500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP 
       510        520        530        540        550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL 
       560        570        580        590        600
KEEELKQGTQ GASSPRSSPS HTISRPIPMP IRSASACPTP THTPQDSLTG 
       610        620        630        640        650
VGGDVQEAFA QSSRRNLRSD LLVAADSITN TMSSLVKELN SEVASETEST 
       660        670        680        690        700
VDSEFSRPQF EDLAPSPTSE KAFLAQIHSR KPGYIHGGAA STTHGDMVPE 
       710        720        730        740 
DGDPYTQPED GNYENESVRQ LENELQLEEY LKQKLQDEAY QVSLQG

Length:746

Mass (Da):84,067

Last modified:February 8, 2011 - v2

Checksum:ⁱ6AB7EF3B69250A09

GO

Isoform 2 (identifier: Q9D2N4-2) [UniParc]FASTA Add to basket

Also known as: Alpha-dystrobrevin-1, Alpha-DB1

The sequence of this isoform differs from the canonical sequence as follows:
363-419: Missing.
560-561: QG → R

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370        380        390        400
VPSSGSPFIT RSMLESSNRL DEEHRLIARY AARLAAESSS SQPTQQRSAP 
       410        420        430        440        450
DISFTIDANK QQRQLIAELE NKNREILQEI QRLRVEHEQA SQPTPEKAQQ 
       460        470        480        490        500
NPTLLAELRL LRQRKDELEQ RMSALQESRR ELMVQLEGLM KLLKEEELKQ 
       510        520        530        540        550
GTRASSPRSS PSHTISRPIP MPIRSASACP TPTHTPQDSL TGVGGDVQEA 
       560        570        580        590        600
FAQSSRRNLR SDLLVAADSI TNTMSSLVKE LNSEVASETE STVDSEFSRP 
       610        620        630        640        650
QFEDLAPSPT SEKAFLAQIH SRKPGYIHGG AASTTHGDMV PEDGDPYTQP 
       660        670        680 
EDGNYENESV RQLENELQLE EYLKQKLQDE AYQVSLQG

Show »

Length:688

Mass (Da):77,733

Checksum:ⁱ82AC1104D48313EA

GO

Isoform 3 (identifier: Q9D2N4-3) [UniParc]FASTA Add to basket

Also known as: Alpha-dystrobrevin-2B, Alpha-DB2B

The sequence of this isoform differs from the canonical sequence as follows:
559-570: TQGASSPRSSPS → VMHEIIPLEERT
571-746: Missing.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370        380        390        400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA 
       410        420        430        440        450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP 
       460        470        480        490        500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP 
       510        520        530        540        550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL 
       560        570
KEEELKQGVM HEIIPLEERT

Show »

Length:570

Mass (Da):65,157

Checksum:ⁱCA135BFB7B7A3DDE

GO

Isoform 4 (identifier: Q9D2N4-4) [UniParc]FASTA Add to basket

Also known as: Alpha-dystrobrevin-2A, Alpha-DB2A

The sequence of this isoform differs from the canonical sequence as follows:
559-567: TQGASSPRS → VSYVPYCRS
568-746: Missing.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370        380        390        400
VPSSGSPFIT RSSPPKDSEV EQNKMLARAA PAFLKGRGIQ YSLNVADRLA 
       410        420        430        440        450
DEHVLIGLYV NMLRNDPPCM LESSNRLDEE HRLIARYAAR LAAESSSSQP 
       460        470        480        490        500
TQQRSAPDIS FTIDANKQQR QLIAELENKN REILQEIQRL RVEHEQASQP 
       510        520        530        540        550
TPEKAQQNPT LLAELRLLRQ RKDELEQRMS ALQESRRELM VQLEGLMKLL 
       560 
KEEELKQGVS YVPYCRS

Show »

Length:567

Mass (Da):64,763

Checksum:ⁱ73C843F6C9E27940

GO

Isoform 5 (identifier: Q9D2N4-5) [UniParc]FASTA Add to basket

Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     364-371: PPKDSEVE → DGAHGGCV
     372-746: Missing.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF 
       360        370 
SHSVPSSGSP FITRSSDGAH GGCV

Show »

Length:374

Mass (Da):42,380

Checksum:ⁱ286DE068A207D235

GO

Isoform 6 (identifier: Q9D2N4-6) [UniParc]FASTA Add to basket

Also known as: Alpha-dystrobrevin-3, Alpha-DB3

The sequence of this isoform differs from the canonical sequence as follows:
364-371: PPKDSEVE → DGAHGGCV
372-746: Missing.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS 
       360        370 
VPSSGSPFIT RSSDGAHGGC V

Show »

Length:371

Mass (Da):41,977

Checksum:ⁱ444BB5947F3D5DD3

GO

Isoform 7 (identifier: Q9D2N4-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-334: V → VDTW
     363-419: Missing.
     559-567: TQGASSPRS → VSYVPYCRS
     568-746: Missing.

« Hide

        10         20         30         40         50
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL 
        60         70         80         90        100
HLVDIWNVIE ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH 
       110        120        130        140        150
QIHVEQSISL LLNFLLAAFD PEGHGKISVF AVKMALATLC GGKIMDKLRY 
       160        170        180        190        200
IFSMISDSSG VMVYGRYDQF LREVLKLPTA VFEGPSFGYT EQSARSCFSQ 
       210        220        230        240        250
QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP VECSYCHSES 
       260        270        280        290        300
MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
       310        320        330        340        350
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF 
       360        370        380        390        400
SHSVPSSGSP FITRSMLESS NRLDEEHRLI ARYAARLAAE SSSSQPTQQR 
       410        420        430        440        450
SAPDISFTID ANKQQRQLIA ELENKNREIL QEIQRLRVEH EQASQPTPEK 
       460        470        480        490        500
AQQNPTLLAE LRLLRQRKDE LEQRMSALQE SRRELMVQLE GLMKLLKEEE 
       510 
LKQGVSYVPY CRS

Show »

Length:513

Mass (Da):58,860

Checksum:ⁱEA3913DA5334D7E1

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8CFR5	Q8CFR5_MOUSE	Dystrobrevin Dystrobrevin	Dtna	682	Annotation score:
A0A1Y7VL34	A0A1Y7VL34_MOUSE	Dystrobrevin Dystrobrevin	Dtna mCG_140483	746	Annotation score:
A0A1Y7VJN9	A0A1Y7VJN9_MOUSE	Dystrobrevin Dystrobrevin	Dtna	567	Annotation score:
A0A1Y7VLZ6	A0A1Y7VLZ6_MOUSE	Dystrobrevin alpha Dystrobrevin alpha	Dtna	73	Annotation score:
A0A1Y7VK79	A0A1Y7VK79_MOUSE	Dystrobrevin alpha Dystrobrevin alpha	Dtna	35	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	241	V → L in CAA64519 (PubMed:8631824).Curated	1
Sequence conflictⁱ	251	M → I in BAB31746 (PubMed:16141072).Curated	1
Sequence conflictⁱ	259	Q → P in AAD33915 (PubMed:10570976).Curated	1
Sequence conflictⁱ	416	D → N in AAD33915 (PubMed:10570976).Curated	1
Sequence conflictⁱ	416	D → N in AAD33914 (PubMed:10570976).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004214	334	V → VDTW in isoform 5 and isoform 7. 2 Publications	1
Alternative sequenceⁱVSP_004215	363 – 419	Missing in isoform 2 and isoform 7. 1 PublicationAdd BLAST	57
Alternative sequenceⁱVSP_004216	364 – 371	PPKDSEVE → DGAHGGCV in isoform 5 and isoform 6. 2 Publications	8
Alternative sequenceⁱVSP_004217	372 – 746	Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST	375
Alternative sequenceⁱVSP_004221	559 – 570	TQGAS…RSSPS → VMHEIIPLEERT in isoform 3. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_004218	559 – 567	TQGASSPRS → VSYVPYCRS in isoform 4 and isoform 7. 2 Publications	9
Alternative sequenceⁱVSP_004220	560 – 561	QG → R in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_004219	568 – 746	Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST	179
Alternative sequenceⁱVSP_004222	571 – 746	Missing in isoform 3. 1 PublicationAdd BLAST	176

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95226 mRNA Translation: CAA64518.1 X95227 mRNA Translation: CAA64519.1 Z79787 Z79797 Genomic DNA Translation: CAB02145.1 AJ009669 mRNA Translation: CAA08770.1 AF143544 mRNA Translation: AAD33915.1 AF143543 mRNA Translation: AAD33914.1 AF143542 mRNA Translation: AAD33913.1 AK019477 mRNA Translation: BAB31746.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29094.1 [Q9D2N4-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001272736.1, NM_001285807.1 NP_001272739.1, NM_001285810.1 NP_001272746.1, NM_001285817.1 NP_034217.2, NM_010087.4 [Q9D2N4-6] XP_017173306.1, XM_017317817.1 XP_017173308.1, XM_017317819.1 [Q9D2N4-7] XP_017173310.1, XM_017317821.1 [Q9D2N4-7] XP_017173311.1, XM_017317822.1 [Q9D2N4-7] XP_017173312.1, XM_017317823.1 [Q9D2N4-7] XP_017173313.1, XM_017317824.1 [Q9D2N4-7] XP_017173315.1, XM_017317826.1 [Q9D2N4-5]
UniGeneⁱ	Mm.484047 Mm.94371

Genome annotation databases

Ensemblⁱ	ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]
GeneIDⁱ	13527
KEGGⁱ	mmu:13527
UCSC genome browser More...UCSCⁱ	uc008efs.2 mouse [Q9D2N4-7] uc008efv.2 mouse [Q9D2N4-4] uc008efw.2 mouse [Q9D2N4-3] uc008efx.2 mouse [Q9D2N4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9D2N4	Dystrobrevin alpha	)	HUMAN		743	UniRef90_Q9Y4J8
Dystrobrevin alpha		TUPCH		790
Dystrobrevin alpha		FUKDA		790
dystrobrevin alpha isoform X4		DELLE		788
Dystrobrevin alpha		PTEAL		788
+254
Q9D2N4-2	Isoform 14 of Dystrobrevin alpha		HUMAN		690	UniRef90_Q9Y4J8-14
Dystrobrevin		CHICK		735
Putative dystrophin-like protein (Fragment)		DESRO		704
Dystrobrevin		OTOGA		694
Dystrobrevin		NEOSC		693
+338
Q9D2N4-3	Isoform 3 of Dystrobrevin alpha		HUMAN		570	UniRef90_Q9Y4J8-3
Dystrobrevin		SAIBB		623
Dystrobrevin		Cebus capucinus imitator		623
Dystrobrevin		AOTNA		618
dystrobrevin alpha isoform X4		BALAS		570
+77
Q9D2N4-4	Isoform 3 of Dystrobrevin alpha		HUMAN		570	UniRef90_Q9Y4J8-3
Dystrobrevin		SAIBB		623
Dystrobrevin		Cebus capucinus imitator		623
Dystrobrevin		AOTNA		618
dystrobrevin alpha isoform X4		BALAS		570
+77
Q9D2N4-5	Isoform 9 of Dystrobrevin alpha		HUMAN		371	UniRef90_Q9Y4J8-9
Dystrobrevin, alpha		COLLI		462
Uncharacterized protein		NOMLE		374
Dystrobrevin alpha isoform 7		CALJA		374
Uncharacterized protein		AOTNA		374
+107
Q9D2N4-6	Isoform 9 of Dystrobrevin alpha		HUMAN		371	UniRef90_Q9Y4J8-9
Dystrobrevin, alpha		COLLI		462
Uncharacterized protein		NOMLE		374
Dystrobrevin alpha isoform 7		CALJA		374
Uncharacterized protein		AOTNA		374
+107
Q9D2N4-7	Uncharacterized protein		MACFA		510	UniRef90_A0A2K5UXS4
Uncharacterized protein		CERAT		510
Uncharacterized protein		MACNE		510
dystrobrevin alpha isoform X3		ODORO		513
dystrobrevin alpha isoform X10		NEOSC		513
+107

Protein	Similar proteins		Species	Score	Length	Source
Q9D2N4	Dystrobrevin alpha	)	HUMAN		743	UniRef50_Q9Y4J8
Dystrobrevin alpha		TUPCH		790
Dystrobrevin alpha		FUKDA		790
dystrobrevin alpha isoform X4		DELLE		788
Dystrobrevin alpha		PTEAL		788
+1175
Q9D2N4-2	Isoform 14 of Dystrobrevin alpha		HUMAN		690	UniRef50_Q9Y4J8-14
Dystrobrevin		CHICK		735
Putative dystrophin-like protein (Fragment)		DESRO		704
Dystrobrevin		OTOGA		694
Dystrobrevin		NEOSC		693
+526
Q9D2N4-3	Isoform 3 of Dystrobrevin alpha		HUMAN		570	UniRef50_Q9Y4J8-3
Dystrobrevin		Cebus capucinus imitator		623
Dystrobrevin		SAIBB		623
Dystrobrevin		AOTNA		618
dystrobrevin alpha isoform X4		BALAS		570
+404
Q9D2N4-4	Isoform 3 of Dystrobrevin alpha		HUMAN		570	UniRef50_Q9Y4J8-3
Dystrobrevin		Cebus capucinus imitator		623
Dystrobrevin		SAIBB		623
Dystrobrevin		AOTNA		618
dystrobrevin alpha isoform X4		BALAS		570
+404
Q9D2N4-5	Isoform 9 of Dystrobrevin alpha		HUMAN		371	UniRef50_Q9Y4J8-9
Dystrobrevin, alpha		COLLI		462
dystrobrevin alpha isoform X15		Florida manatee		374
DTNA isoform 3		PANTR		374
dystrobrevin alpha isoform X8		ERIEU		374
+161
Q9D2N4-6	Isoform 9 of Dystrobrevin alpha		HUMAN		371	UniRef50_Q9Y4J8-9
Dystrobrevin, alpha		COLLI		462
dystrobrevin alpha isoform X15		Florida manatee		374
DTNA isoform 3		PANTR		374
dystrobrevin alpha isoform X8		ERIEU		374
+161
Q9D2N4-7	Isoform 3 of Dystrobrevin alpha		HUMAN		570	UniRef50_Q9Y4J8-3
Dystrobrevin		Cebus capucinus imitator		623
Dystrobrevin		SAIBB		623
Dystrobrevin		AOTNA		618
dystrobrevin alpha isoform X4		BALAS		570
+404

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95226 mRNA Translation: CAA64518.1 X95227 mRNA Translation: CAA64519.1 Z79787 Z79797 Genomic DNA Translation: CAB02145.1 AJ009669 mRNA Translation: CAA08770.1 AF143544 mRNA Translation: AAD33915.1 AF143543 mRNA Translation: AAD33914.1 AF143542 mRNA Translation: AAD33913.1 AK019477 mRNA Translation: BAB31746.1
CCDSⁱ	CCDS29094.1 [Q9D2N4-6]
RefSeqⁱ	NP_001272736.1, NM_001285807.1 NP_001272739.1, NM_001285810.1 NP_001272746.1, NM_001285817.1 NP_034217.2, NM_010087.4 [Q9D2N4-6] XP_017173306.1, XM_017317817.1 XP_017173308.1, XM_017317819.1 [Q9D2N4-7] XP_017173310.1, XM_017317821.1 [Q9D2N4-7] XP_017173311.1, XM_017317822.1 [Q9D2N4-7] XP_017173312.1, XM_017317823.1 [Q9D2N4-7] XP_017173313.1, XM_017317824.1 [Q9D2N4-7] XP_017173315.1, XM_017317826.1 [Q9D2N4-5]
UniGeneⁱ	Mm.484047 Mm.94371

3D structure databases

ProteinModelPortalⁱ	Q9D2N4
SMRⁱ	Q9D2N4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199334, 2 interactors
CORUMⁱ	Q9D2N4
IntActⁱ	Q9D2N4, 9 interactors

PTM databases

iPTMnetⁱ	Q9D2N4
PhosphoSitePlusⁱ	Q9D2N4
SwissPalmⁱ	Q9D2N4

Proteomic databases

PeptideAtlasⁱ	Q9D2N4
PRIDEⁱ	Q9D2N4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047954; ENSMUSP00000037475; ENSMUSG00000024302 [Q9D2N4-6]
GeneIDⁱ	13527
KEGGⁱ	mmu:13527
UCSCⁱ	uc008efs.2 mouse [Q9D2N4-7] uc008efv.2 mouse [Q9D2N4-4] uc008efw.2 mouse [Q9D2N4-3] uc008efx.2 mouse [Q9D2N4-1]

Organism-specific databases

CTDⁱ	1837
MGIⁱ	MGI:106039 Dtna

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119237
HOVERGENⁱ	HBG005539
InParanoidⁱ	Q9D2N4
PhylomeDBⁱ	Q9D2N4

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9D2N4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024302 Expressed in 263 organ(s), highest expression level in saccule of membranous labyrinth
CleanExⁱ	MM_DTNA
ExpressionAtlasⁱ	Q9D2N4 baseline and differential
Genevisibleⁱ	Q9D2N4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR017432 Distrobrevin IPR011992 EF-hand-dom_pair IPR015153 EF-hand_dom_typ1 IPR015154 EF-hand_dom_typ2 IPR000433 Znf_ZZ
Pfamⁱ	View protein in Pfam PF09068 EF-hand_2, 1 hit PF09069 EF-hand_3, 1 hit PF00569 ZZ, 1 hit
PIRSFⁱ	PIRSF038204 Distrobrevin, 1 hit
SMARTⁱ	View protein in SMART SM00291 ZnF_ZZ, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 2 hits
PROSITEⁱ	View protein in PROSITE PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DTNA_MOUSE
Accessionⁱ	Q9D2N4Primary (citable) accession number: Q9D2N4 Secondary accession number(s): P97319 , Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	February 8, 2011
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9D2N4 (DTNA_MOUSE)

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Dystrobrevin alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ