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Protein

LisH domain-containing protein ARMC9

Gene

Armc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for ciliogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain-containing protein ARMC9
Gene namesi
Name:Armc9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1926045 Armc9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805961 – 817LisH domain-containing protein ARMC9Add BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei583PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2I5
PRIDEiQ9D2I5

PTM databases

iPTMnetiQ9D2I5
PhosphoSitePlusiQ9D2I5

Expressioni

Gene expression databases

BgeeiENSMUSG00000062590 Expressed in 187 organ(s), highest expression level in testis
CleanExiMM_ARMC9
ExpressionAtlasiQ9D2I5 baseline and differential
GenevisibleiQ9D2I5 MM

Interactioni

Protein-protein interaction databases

BioGridi219638, 1 interactor
STRINGi10090.ENSMUSP00000027434

Structurei

3D structure databases

ProteinModelPortaliQ9D2I5
SMRiQ9D2I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 39LisHPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili204 – 230Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGND Eukaryota
ENOG410YSH6 LUCA
GeneTreeiENSGT00390000018026
HOVERGENiHBG080866
InParanoidiQ9D2I5
KOiK22864
OMAiGRPDKED
OrthoDBiEOG091G04U2
PhylomeDBiQ9D2I5
TreeFamiTF317676

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR006594 LisH
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (9+)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2I5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKVKGK PLCKNVGGPL
60 70 80 90 100
KKDSKSLVIQ RDLVAAFDSG DQKAFFDLWE GHIPSSVRDT DSLAQKLEFY
110 120 130 140 150
LHIHFAIYLL KYCRGRPDKQ ELDKRISYFK TYLETKGAAL SQTTEFLPFY
160 170 180 190 200
ALPFVPNPMV HPSFKELFQD SWTPELKLKL EKFLALTFKA NNTPKLLTIY
210 220 230 240 250
KENGPNSKEL LQQLHQQLVE AERRAMTYLK RYNKIQADYH NLIGVTAELV
260 270 280 290 300
DSLEATVSGK MITPEYLQSV CVRLFSNQMR QSLAHSVDFT RPGTASTMLR
310 320 330 340 350
ASLAPEKLKD VPLLPSLDYE KLKKDLIWGS DRLKAFLLQA LRWRLTTSHP
360 370 380 390 400
GEQRETVLQA YISNDLLDCH SHNQRSVLQL LHSKSEAVRQ YMARLINALA
410 420 430 440 450
SLAEGRLYLA QNTKVLRMLE GRLKEEDKDV ITRENVLGAL QKFSLRRPLQ
460 470 480 490 500
TAMIRDGLIF WLIDLLKDPD CLSDYTLEYS VALLMNLCLR SAGKNMCAKV
510 520 530 540 550
AGLMLKVLSD LLGHENHEIQ PYVNGALYSI LSIPSIREEA RAMGMEDILR
560 570 580 590 600
CFIKEGNAEM IRQIEFIIKQ LNSEDLLDGV LESDDDEDED DEEDHDIMEA
610 620 630 640 650
DLDKDELIQP QLGELSGEKL LTTEYLGIMT NTGKARRKGP ASVQWSGDEP
660 670 680 690 700
LRRPVTPGGH RTGCPVLGDH LISPQNAQQA RNGCLRAMPV AHPDDYKEGK
710 720 730 740 750
PGVTGCGTSS SFMDHKPREW SPAGHQKSRL VPTAALGWPR EMTQDPSSGH
760 770 780 790 800
ITREFVPAFT CKPQVPSTPE TVEQNPLKAK ALSLAPQFSS SGPQQASRPA
810
STASSTRGLH SSQSIRK
Length:817
Mass (Da):91,922
Last modified:June 1, 2001 - v1
Checksum:i0E1F2899F9287A23
GO
Isoform 2 (identifier: Q9D2I5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-817: Missing.

Show »
Length:666
Mass (Da):75,760
Checksum:i622AE03ACA18CDBC
GO
Isoform 3 (identifier: Q9D2I5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-712: F → SV

Show »
Length:818
Mass (Da):91,961
Checksum:i5B1A5EA13293B03E
GO
Isoform 4 (identifier: Q9D2I5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-731: FMDHKPREWSPAGHQKSRLV → CKNAVGAKPVLSSWAQESKR
     732-817: Missing.

Show »
Length:731
Mass (Da):82,549
Checksum:iA3011EDFCD7BC55C
GO
Isoform 5 (identifier: Q9D2I5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: Missing.

Show »
Length:816
Mass (Da):91,793
Checksum:i18DD2431B0244F23
GO
Isoform 6 (identifier: Q9D2I5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-559: Missing.
     712-731: FMDHKPREWSPAGHQKSRLV → CKNAVGAKPVLSSWAQESKR
     732-817: Missing.

Show »
Length:172
Mass (Da):18,766
Checksum:i5126BEEEB893CDC7
GO
Isoform 7 (identifier: Q9D2I5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-235: Missing.
     236-236: Q → M
     712-731: FMDHKPREWSPAGHQKSRLV → CKNAVGAKPVLSSWAQESKR
     732-817: Missing.

Show »
Length:496
Mass (Da):55,335
Checksum:iE1ED3F63CB120A3F
GO
Isoform 8 (identifier: Q9D2I5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-314: ASTMLRASLAPEKLKDVPLL → GTEDWAEKGDHISKPKRGTR
     315-817: Missing.

Show »
Length:314
Mass (Da):35,993
Checksum:i0A6EF47C479290FB
GO
Isoform 9 (identifier: Q9D2I5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-205: KENGP → VSFMK
     206-817: Missing.

Show »
Length:205
Mass (Da):23,617
Checksum:i1C0C929D820B17EB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7B303F7B303_MOUSE
LisH domain-containing protein ARMC...
Armc9
254Annotation score:
F6QPP0F6QPP0_MOUSE
LisH domain-containing protein ARMC...
Armc9
145Annotation score:
A0A087WNY0A0A087WNY0_MOUSE
LisH domain-containing protein ARMC...
Armc9
107Annotation score:
F7AY77F7AY77_MOUSE
LisH domain-containing protein ARMC...
Armc9
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36K → Q in BAC26890 (PubMed:16141072).Curated1
Sequence conflicti153P → T in BAC33231 (PubMed:16141072).Curated1
Sequence conflicti277N → K in BAC26890 (PubMed:16141072).Curated1
Sequence conflicti427D → G in BAC29299 (PubMed:16141072).Curated1
Sequence conflicti437L → I in BAC32462 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238051 – 559Missing in isoform 6. 1 PublicationAdd BLAST559
Alternative sequenceiVSP_0238061 – 235Missing in isoform 7. 1 PublicationAdd BLAST235
Alternative sequenceiVSP_023807201 – 205KENGP → VSFMK in isoform 9. 1 Publication5
Alternative sequenceiVSP_023808206 – 817Missing in isoform 9. 1 PublicationAdd BLAST612
Alternative sequenceiVSP_023809236Q → M in isoform 7. 1 Publication1
Alternative sequenceiVSP_023810295 – 314ASTML…DVPLL → GTEDWAEKGDHISKPKRGTR in isoform 8. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023813315 – 817Missing in isoform 8. 1 PublicationAdd BLAST503
Alternative sequenceiVSP_023811574Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_023812667 – 817Missing in isoform 2. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_023814712 – 731FMDHK…KSRLV → CKNAVGAKPVLSSWAQESKR in isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_023815712F → SV in isoform 3. 1 Publication1
Alternative sequenceiVSP_023816732 – 817Missing in isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017564 mRNA Translation: BAB30807.1
AK019512 mRNA Translation: BAB31770.1
AK019600 mRNA Translation: BAB31811.1
AK030307 mRNA Translation: BAC26890.1
AK036083 mRNA Translation: BAC29299.1
AK039800 mRNA Translation: BAC30457.1
AK046693 mRNA Translation: BAC32837.1
AK045699 mRNA Translation: BAC32462.1
AK048064 mRNA Translation: BAC33231.1
AK076239 mRNA Translation: BAC36270.1
AK161393 mRNA Translation: BAE36370.1
BC028964 mRNA Translation: AAH28964.1
BC043101 mRNA Translation: AAH43101.1
CCDSiCCDS15118.1 [Q9D2I5-1]
CCDS48303.1 [Q9D2I5-2]
CCDS78642.1 [Q9D2I5-3]
RefSeqiNP_001297631.1, NM_001310702.1 [Q9D2I5-3]
NP_081732.1, NM_027456.2 [Q9D2I5-2]
NP_084460.1, NM_030184.2 [Q9D2I5-1]
XP_006530019.1, XM_006529956.3 [Q9D2I5-5]
UniGeneiMm.379264

Genome annotation databases

EnsembliENSMUST00000027434; ENSMUSP00000027434; ENSMUSG00000062590 [Q9D2I5-1]
ENSMUST00000113309; ENSMUSP00000108934; ENSMUSG00000062590 [Q9D2I5-3]
ENSMUST00000131412; ENSMUSP00000117267; ENSMUSG00000062590 [Q9D2I5-2]
GeneIDi78795
KEGGimmu:78795
UCSCiuc007bva.1 mouse [Q9D2I5-9]
uc007bvb.1 mouse [Q9D2I5-8]
uc007bvc.1 mouse [Q9D2I5-1]
uc007bvf.1 mouse [Q9D2I5-4]
uc007bvh.1 mouse [Q9D2I5-5]
uc007bvi.1 mouse [Q9D2I5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017564 mRNA Translation: BAB30807.1
AK019512 mRNA Translation: BAB31770.1
AK019600 mRNA Translation: BAB31811.1
AK030307 mRNA Translation: BAC26890.1
AK036083 mRNA Translation: BAC29299.1
AK039800 mRNA Translation: BAC30457.1
AK046693 mRNA Translation: BAC32837.1
AK045699 mRNA Translation: BAC32462.1
AK048064 mRNA Translation: BAC33231.1
AK076239 mRNA Translation: BAC36270.1
AK161393 mRNA Translation: BAE36370.1
BC028964 mRNA Translation: AAH28964.1
BC043101 mRNA Translation: AAH43101.1
CCDSiCCDS15118.1 [Q9D2I5-1]
CCDS48303.1 [Q9D2I5-2]
CCDS78642.1 [Q9D2I5-3]
RefSeqiNP_001297631.1, NM_001310702.1 [Q9D2I5-3]
NP_081732.1, NM_027456.2 [Q9D2I5-2]
NP_084460.1, NM_030184.2 [Q9D2I5-1]
XP_006530019.1, XM_006529956.3 [Q9D2I5-5]
UniGeneiMm.379264

3D structure databases

ProteinModelPortaliQ9D2I5
SMRiQ9D2I5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219638, 1 interactor
STRINGi10090.ENSMUSP00000027434

PTM databases

iPTMnetiQ9D2I5
PhosphoSitePlusiQ9D2I5

Proteomic databases

PaxDbiQ9D2I5
PRIDEiQ9D2I5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027434; ENSMUSP00000027434; ENSMUSG00000062590 [Q9D2I5-1]
ENSMUST00000113309; ENSMUSP00000108934; ENSMUSG00000062590 [Q9D2I5-3]
ENSMUST00000131412; ENSMUSP00000117267; ENSMUSG00000062590 [Q9D2I5-2]
GeneIDi78795
KEGGimmu:78795
UCSCiuc007bva.1 mouse [Q9D2I5-9]
uc007bvb.1 mouse [Q9D2I5-8]
uc007bvc.1 mouse [Q9D2I5-1]
uc007bvf.1 mouse [Q9D2I5-4]
uc007bvh.1 mouse [Q9D2I5-5]
uc007bvi.1 mouse [Q9D2I5-3]

Organism-specific databases

CTDi80210
MGIiMGI:1926045 Armc9

Phylogenomic databases

eggNOGiENOG410IGND Eukaryota
ENOG410YSH6 LUCA
GeneTreeiENSGT00390000018026
HOVERGENiHBG080866
InParanoidiQ9D2I5
KOiK22864
OMAiGRPDKED
OrthoDBiEOG091G04U2
PhylomeDBiQ9D2I5
TreeFamiTF317676

Miscellaneous databases

ChiTaRSiArmc9 mouse
PROiPR:Q9D2I5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062590 Expressed in 187 organ(s), highest expression level in testis
CleanExiMM_ARMC9
ExpressionAtlasiQ9D2I5 baseline and differential
GenevisibleiQ9D2I5 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR006594 LisH
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARMC9_MOUSE
AccessioniPrimary (citable) accession number: Q9D2I5
Secondary accession number(s): Q8BQQ3
, Q8BR45, Q8BSX7, Q8C6A6, Q8C889, Q8CA23, Q8CBG2, Q8K112, Q9CYL1, Q9D2L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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