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Protein

Dynein assembly factor 1, axonemal

Gene

Dnaaf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein assembly factor 1, axonemal
Alternative name(s):
Leucine-rich repeat-containing protein 50
Gene namesi
Name:Dnaaf1
Synonyms:Lrrc50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915520 Dnaaf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328901 – 634Dynein assembly factor 1, axonemalAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineBy similarity1
Modified residuei462PhosphothreonineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2H9
PRIDEiQ9D2H9

PTM databases

iPTMnetiQ9D2H9
PhosphoSitePlusiQ9D2H9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031831 Expressed in 68 organ(s), highest expression level in testis
CleanExiMM_LRRC50
GenevisibleiQ9D2H9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090790

Structurei

3D structure databases

ProteinModelPortaliQ9D2H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 123LRR 1Add BLAST23
Repeati124 – 145LRR 2Add BLAST22
Repeati146 – 167LRR 3Add BLAST22
Repeati168 – 189LRR 4Add BLAST22
Repeati190 – 211LRR 5Add BLAST22
Repeati215 – 236LRR 6Add BLAST22
Domaini249 – 288LRRCTAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi392 – 395Poly-Val4

Sequence similaritiesi

Belongs to the DNAAF1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IG8N Eukaryota
ENOG410XQAN LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG066969
InParanoidiQ9D2H9
KOiK19750
OMAiCLFLQVN
OrthoDBiEOG091G01J2
PhylomeDBiQ9D2H9
TreeFamiTF315818

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR027734 DNAAF1
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PANTHERiPTHR45256 PTHR45256, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Q9D2H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPEVSEPPV DSVAEPSLEE SAGDHGDAGP GIRKEEISET KETCAGPCTT
60 70 80 90 100
SCPSQQQPSG DNGSEGFCTH SRDDREDRGP RMTKQFLQKL CKQHKLYVTP
110 120 130 140 150
ALNDTLYLHF KGFDRIENLE EYTGLRCLWL ECNGIQRIEN LQAQSELRCL
160 170 180 190 200
FLQVNLLHKI ENLEPLQKLD ALNLSNNYIK TIENLSCLPV LNTLQMAHNR
210 220 230 240 250
LETVADIEHL RECLRLCVLD LSHNALSDPE ILSVLESMPC LRVLNLMGNP
260 270 280 290 300
VTKHIPNYRR TVTVRLKHLT YLDDRPVFPK DRACAEAWAR GGYAAEKEER
310 320 330 340 350
RQWESREHKK ITDSLEALAM IKRRAEERKK ARDRGETPLP DSEGSIPTSP
360 370 380 390 400
EAEEKQPMGE IQKKMELFVE ESFEAKDELF PETPGGEKEL HVVVVNGAVE
410 420 430 440 450
NPDLSGSLAH NQTPVVVTPE ESTSPVAATD GARTEDIEAV AVEIKERLFI
460 470 480 490 500
DDLPDLEDAE GTDVSVEDQI KETDIPRIQA ISSLSDDSDP ELDELSLSTS
510 520 530 540 550
EATPTGATGA LSHIFAISKG PSTAATVPFT DICKPIATTD LESQGQDCGA
560 570 580 590 600
AASRPLIQEL NDEPAEEAAN QPLPPQTCAS DPALAHPSED GDSDSQLPAA
610 620 630
TLLGDGAEDE AESSVHPKEP STRVGLEDIE FGLD
Length:634
Mass (Da):69,704
Last modified:June 1, 2001 - v1
Checksum:i4B174F328D433754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006656 mRNA Translation: BAB24692.1
AK019633 mRNA Translation: BAB31818.1
BC050751 mRNA Translation: AAH50751.1
CCDSiCCDS22709.1
RefSeqiNP_080924.1, NM_026648.4
UniGeneiMm.41977
Mm.475128

Genome annotation databases

EnsembliENSMUST00000093100; ENSMUSP00000090790; ENSMUSG00000031831
GeneIDi68270
KEGGimmu:68270
UCSCiuc009npw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006656 mRNA Translation: BAB24692.1
AK019633 mRNA Translation: BAB31818.1
BC050751 mRNA Translation: AAH50751.1
CCDSiCCDS22709.1
RefSeqiNP_080924.1, NM_026648.4
UniGeneiMm.41977
Mm.475128

3D structure databases

ProteinModelPortaliQ9D2H9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090790

PTM databases

iPTMnetiQ9D2H9
PhosphoSitePlusiQ9D2H9

Proteomic databases

PaxDbiQ9D2H9
PRIDEiQ9D2H9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093100; ENSMUSP00000090790; ENSMUSG00000031831
GeneIDi68270
KEGGimmu:68270
UCSCiuc009npw.1 mouse

Organism-specific databases

CTDi123872
MGIiMGI:1915520 Dnaaf1

Phylogenomic databases

eggNOGiENOG410IG8N Eukaryota
ENOG410XQAN LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG066969
InParanoidiQ9D2H9
KOiK19750
OMAiCLFLQVN
OrthoDBiEOG091G01J2
PhylomeDBiQ9D2H9
TreeFamiTF315818

Miscellaneous databases

ChiTaRSiDnaaf1 mouse
PROiPR:Q9D2H9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031831 Expressed in 68 organ(s), highest expression level in testis
CleanExiMM_LRRC50
GenevisibleiQ9D2H9 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR027734 DNAAF1
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PANTHERiPTHR45256 PTHR45256, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDAAF1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2H9
Secondary accession number(s): Q9CVS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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