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UniProtKB - Q9D2H6 (SP2_MOUSE)
Protein
Transcription factor Sp2
Gene
Sp2
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 524 – 548 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 554 – 578 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 584 – 606 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- histone deacetylase binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- circulatory system development Source: MGI
- embryonic organ development Source: MGI
- fibroblast proliferation Source: MGI
- in utero embryonic development Source: MGI
- multicellular organism growth Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sp2 |
Gene namesi | Name:Sp2 Synonyms:Kiaa0048 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926162, Sp2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269192 | 1 – 612 | Transcription factor Sp2Add BLAST | 612 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9D2H6 |
MaxQBi | Q9D2H6 |
PaxDbi | Q9D2H6 |
PRIDEi | Q9D2H6 |
ProteomicsDBi | 257547 [Q9D2H6-1] 257548 [Q9D2H6-2] |
PTM databases
iPTMneti | Q9D2H6 |
PhosphoSitePlusi | Q9D2H6 |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 219700, 5 interactors |
IntActi | Q9D2H6, 2 interactors |
STRINGi | 10090.ENSMUSP00000103252 |
Miscellaneous databases
RNActi | Q9D2H6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 195 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 226 – 250 | DisorderedSequence analysisAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 360 – 368 | 9aaTAD; inactiveBy similarity | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 226 – 241 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.By similarity
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 524 – 548 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 554 – 578 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 584 – 606 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q9D2H6 |
OrthoDBi | 1085860at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9D2H6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ
110 120 130 140 150
LSTSYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPS
160 170 180 190 200
LTNQIQVIPG TNQAITTPST SGHKPVPIKP APVQKSSTTT TPVQSGANVV
210 220 230 240 250
KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS KTNKKARKKS
260 270 280 290 300
LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV
310 320 330 340 350
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP
360 370 380 390 400
TQVYIRTPSG EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH
410 420 430 440 450
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV
460 470 480 490 500
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR
510 520 530 540 550
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG
560 570 580 590 600
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT
610
KHYKTHLGTK GL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8C5J0 | Q8C5J0_MOUSE | Transcription factor Sp2 | Sp2 | 613 | Annotation score: | ||
Q8BNQ4 | Q8BNQ4_MOUSE | Transcription factor Sp2 | Sp2 | 607 | Annotation score: |
Sequence cautioni
The sequence AAH21759 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH86457 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32155 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | M → T in AAH86457 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 97 | Missing in BAD32155 (PubMed:15368895).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022022 | 1 – 7 | Missing in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172877 Transcribed RNA Translation: BAD32155.1 Different initiation. AK019649 mRNA Translation: BAB31823.1 BC021759 mRNA Translation: AAH21759.1 Different initiation. BC086457 mRNA Translation: AAH86457.1 Different initiation. |
RefSeqi | NP_001074433.1, NM_001080964.1 [Q9D2H6-1] NP_084496.2, NM_030220.3 |
Genome annotation databases
GeneIDi | 78912 |
KEGGi | mmu:78912 |
UCSCi | uc007ldg.1, mouse [Q9D2H6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK172877 Transcribed RNA Translation: BAD32155.1 Different initiation. AK019649 mRNA Translation: BAB31823.1 BC021759 mRNA Translation: AAH21759.1 Different initiation. BC086457 mRNA Translation: AAH86457.1 Different initiation. |
RefSeqi | NP_001074433.1, NM_001080964.1 [Q9D2H6-1] NP_084496.2, NM_030220.3 |
3D structure databases
SMRi | Q9D2H6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 219700, 5 interactors |
IntActi | Q9D2H6, 2 interactors |
STRINGi | 10090.ENSMUSP00000103252 |
PTM databases
iPTMneti | Q9D2H6 |
PhosphoSitePlusi | Q9D2H6 |
Proteomic databases
jPOSTi | Q9D2H6 |
MaxQBi | Q9D2H6 |
PaxDbi | Q9D2H6 |
PRIDEi | Q9D2H6 |
ProteomicsDBi | 257547 [Q9D2H6-1] 257548 [Q9D2H6-2] |
Protocols and materials databases
DNASUi | 78912 |
Genome annotation databases
GeneIDi | 78912 |
KEGGi | mmu:78912 |
UCSCi | uc007ldg.1, mouse [Q9D2H6-1] |
Organism-specific databases
CTDi | 6668 |
MGIi | MGI:1926162, Sp2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q9D2H6 |
OrthoDBi | 1085860at2759 |
Miscellaneous databases
BioGRID-ORCSi | 78912, 4 hits in 62 CRISPR screens |
ChiTaRSi | Sp2, mouse |
PROi | PR:Q9D2H6 |
RNActi | Q9D2H6, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SP2_MOUSE | |
Accessioni | Q9D2H6Primary (citable) accession number: Q9D2H6 Secondary accession number(s): Q6A0E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families