Transcription factor Sp2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 15820306
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• histone deacetylase binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• cardiovascular system development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20221402
• embryonic organ development Source: MGIInferred from mutant phenotypeⁱ
  • 20221402
• fibroblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 20221402
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 20221402
• multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • 20221402
• negative regulation of transcription by RNA polymerase II Source: MGI
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSDPQMSMAA TAAVSPSDYL QPAAATTQDS QPSPLALLAA TCSKIGPPAV 
        60         70         80         90        100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ 
       110        120        130        140        150
LSTSYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPS 
       160        170        180        190        200
LTNQIQVIPG TNQAITTPST SGHKPVPIKP APVQKSSTTT TPVQSGANVV 
       210        220        230        240        250
KLTGGGSNMT LTLPLNNLVN TSDIGGPAQL LTESPPTPLS KTNKKARKKS 
       260        270        280        290        300
LPVSQPSVAV AEQVETVLIE TTADNIIQAG NNLLIVQSPG GGQPAVVQQV 
       310        320        330        340        350
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP 
       360        370        380        390        400
TQVYIRTPSG EVQTVLVQDS PPATAATTST VTCNSPALRA PHLSGTSKKH 
       410        420        430        440        450
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV 
       460        470        480        490        500
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR 
       510        520        530        540        550
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG 
       560        570        580        590        600
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT 
       610 
KHYKTHLGTK GL                                          

        10         20         30         40         50
MAATAAVSPS DYLQPAAATT QDSQPSPLAL LAATCSKIGP PAVEAAVTPP 
        60         70         80         90        100
APPQPTPRKL VPIKPAPLPL SPCKNSFSIL SSKGNILQIQ GSQLSTSYPG 
       110        120        130        140        150
GQFVFAIQNP TLINKGSRSN ASIQYQVPQI QGNSSQTIQV QPSLTNQIQV 
       160        170        180        190        200
IPGTNQAITT PSTSGHKPVP IKPAPVQKSS TTTTPVQSGA NVVKLTGGGS 
       210        220        230        240        250
NMTLTLPLNN LVNTSDIGGP AQLLTESPPT PLSKTNKKAR KKSLPVSQPS 
       260        270        280        290        300
VAVAEQVETV LIETTADNII QAGNNLLIVQ SPGGGQPAVV QQVQVVPPKA 
       310        320        330        340        350
EQQQVVQIPQ QALRVVQAAS ATLPTVPQKP SQNFQIQTTE PTPTQVYIRT 
       360        370        380        390        400
PSGEVQTVLV QDSPPATAAT TSTVTCNSPA LRAPHLSGTS KKHSAAILRK 
       410        420        430        440        450
ERPLPKIAPA GSIISLNAAQ LAAAAQAMQT ININGVQVQG VPVTITNTGG 
       460        470        480        490        500
QQQLTVQNVS GNNLTISGLS PTQIQLQMEQ ALAGEAQPGE KRRRMACTCP 
       510        520        530        540        550
NCKDGEKRSG EQGKKKHVCH IPDCGKTFRK TSLLRAHVRL HTGERPFVCN 
       560        570        580        590        600
WFFCGKRFTR SDELQRHART HTGDKRFECA QCQKRFMRSD HLTKHYKTHL 

GTKGL                                                  

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot