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Protein

Target of EGR1 protein 1

Gene

Toe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 323C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Target of EGR1 protein 1
Gene namesi
Name:Toe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915526 Toe1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002708342 – 511Target of EGR1 protein 1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei429PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D2E2
PaxDbiQ9D2E2
PeptideAtlasiQ9D2E2
PRIDEiQ9D2E2

PTM databases

iPTMnetiQ9D2E2
PhosphoSitePlusiQ9D2E2

Expressioni

Gene expression databases

BgeeiENSMUSG00000028688 Expressed in 252 organ(s), highest expression level in humerus cartilage element
CleanExiMM_TOE1
ExpressionAtlasiQ9D2E2 baseline and differential
GenevisibleiQ9D2E2 MM

Interactioni

Subunit structurei

Interacts with U1, U2, U4, U5 and U6 snRNAs.By similarity

Protein-protein interaction databases

IntActiQ9D2E2, 2 interactors
STRINGi10090.ENSMUSP00000030451

Structurei

3D structure databases

ProteinModelPortaliQ9D2E2
SMRiQ9D2E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi336 – 348Nuclear localization signalBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the CAF1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 323C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR2Y Eukaryota
ENOG410XNUS LUCA
GeneTreeiENSGT00390000004077
HOGENOMiHOG000231417
HOVERGENiHBG080270
InParanoidiQ9D2E2
KOiK13202
OMAiGTHRAGF
OrthoDBiEOG091G0L18
PhylomeDBiQ9D2E2
TreeFamiTF314502

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF04857 CAF1, 2 hits
PF00642 zf-CCCH, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS
60 70 80 90 100
LLLALKTASF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL
110 120 130 140 150
GLACFRQQPD KGENSYLAQV FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR
160 170 180 190 200
QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY
210 220 230 240 250
QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK
260 270 280 290 300
CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI
310 320 330 340 350
CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRSL
360 370 380 390 400
QSQPGTQTLA EAEDGPPTKQ VCEDSLETEK MEQKVAEGEA GDQPGSREGH
410 420 430 440 450
TSSLEMAHRR TSAETADVAT SELLVNQAST NPVPGDGLHR AGFDAFMTGY
460 470 480 490 500
VMAYVGLSQG LQLCSSEPWL PECHNKVYLS GKTVPLTVTK SQFSRPSKAH
510
NQKMKLAWGS S
Length:511
Mass (Da):56,871
Last modified:June 1, 2001 - v1
Checksum:iB7E9946A352BED90
GO
Isoform 2 (identifier: Q9D2E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-329: AYGWCPLGPQCPQSHDIDLIIDTD → HTRSRFTGQLWETTIFPVEKLKDI
     330-511: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,149
Checksum:i09D4313BD4E6C3FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZMT3F6ZMT3_MOUSE
Target of EGR1 protein 1
Toe1
188Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8D → G in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti15P → S in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti26P → S in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti128I → M in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti182R → W in BAB30482 (PubMed:16141072).Curated1
Sequence conflicti278S → R in AAH23109 (PubMed:15489334).Curated1
Sequence conflicti360A → V in AAH23109 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022242306 – 329AYGWC…IIDTD → HTRSRFTGQLWETTIFPVEK LKDI in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_022243330 – 511Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016889 mRNA Translation: BAB30482.1
AK019829 mRNA Translation: BAB31871.1
AK046576 mRNA Translation: BAC32792.1
AK082975 mRNA Translation: BAC38718.1
AK148609 mRNA Translation: BAE28623.1
BC023109 mRNA Translation: AAH23109.1
CCDSiCCDS18517.1 [Q9D2E2-1]
RefSeqiNP_080930.1, NM_026654.2 [Q9D2E2-1]
UniGeneiMm.30534

Genome annotation databases

EnsembliENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1]
ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2]
GeneIDi68276
KEGGimmu:68276
UCSCiuc008uhk.1 mouse [Q9D2E2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016889 mRNA Translation: BAB30482.1
AK019829 mRNA Translation: BAB31871.1
AK046576 mRNA Translation: BAC32792.1
AK082975 mRNA Translation: BAC38718.1
AK148609 mRNA Translation: BAE28623.1
BC023109 mRNA Translation: AAH23109.1
CCDSiCCDS18517.1 [Q9D2E2-1]
RefSeqiNP_080930.1, NM_026654.2 [Q9D2E2-1]
UniGeneiMm.30534

3D structure databases

ProteinModelPortaliQ9D2E2
SMRiQ9D2E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D2E2, 2 interactors
STRINGi10090.ENSMUSP00000030451

PTM databases

iPTMnetiQ9D2E2
PhosphoSitePlusiQ9D2E2

Proteomic databases

EPDiQ9D2E2
PaxDbiQ9D2E2
PeptideAtlasiQ9D2E2
PRIDEiQ9D2E2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1]
ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2]
GeneIDi68276
KEGGimmu:68276
UCSCiuc008uhk.1 mouse [Q9D2E2-1]

Organism-specific databases

CTDi114034
MGIiMGI:1915526 Toe1

Phylogenomic databases

eggNOGiENOG410IR2Y Eukaryota
ENOG410XNUS LUCA
GeneTreeiENSGT00390000004077
HOGENOMiHOG000231417
HOVERGENiHBG080270
InParanoidiQ9D2E2
KOiK13202
OMAiGTHRAGF
OrthoDBiEOG091G0L18
PhylomeDBiQ9D2E2
TreeFamiTF314502

Miscellaneous databases

PROiPR:Q9D2E2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028688 Expressed in 252 organ(s), highest expression level in humerus cartilage element
CleanExiMM_TOE1
ExpressionAtlasiQ9D2E2 baseline and differential
GenevisibleiQ9D2E2 MM

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF04857 CAF1, 2 hits
PF00642 zf-CCCH, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOE1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2E2
Secondary accession number(s): Q3UFD8, Q8R5A4, Q9D412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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