UniProtKB - Q9D2E2 (TOE1_MOUSE)
Protein
Target of EGR1 protein 1
Gene
Toe1
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 323 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- 3'-5'-exoribonuclease activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- poly(A)-specific ribonuclease activity Source: MGI
- RNA binding Source: GO_Central
- snRNA binding Source: UniProtKB
GO - Biological processi
- RNA phosphodiester bond hydrolysis, exonucleolytic Source: MGI
- snRNA 3'-end processing Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Target of EGR1 protein 1 |
Gene namesi | Name:Toe1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915526, Toe1 |
Subcellular locationi
Nucleus
- nucleolus By similarity
- Nucleus speckle By similarity
Note: Localizes to nuclear speckles.By similarity
Nucleus
- Cajal body Source: MGI
- nuclear body Source: MGI
- nuclear speck Source: UniProtKB-SubCell
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000270834 | 2 – 511 | Target of EGR1 protein 1Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 5 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 429 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9D2E2 |
jPOSTi | Q9D2E2 |
PaxDbi | Q9D2E2 |
PeptideAtlasi | Q9D2E2 |
PRIDEi | Q9D2E2 |
PTM databases
iPTMneti | Q9D2E2 |
PhosphoSitePlusi | Q9D2E2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028688, Expressed in humerus cartilage element and 271 other tissues |
ExpressionAtlasi | Q9D2E2, baseline and differential |
Genevisiblei | Q9D2E2, MM |
Interactioni
Subunit structurei
Interacts with U1, U2, U4, U5 and U6 snRNAs.
By similarityProtein-protein interaction databases
BioGRIDi | 212779, 2 interactors |
IntActi | Q9D2E2, 2 interactors |
STRINGi | 10090.ENSMUSP00000030451 |
Miscellaneous databases
RNActi | Q9D2E2, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 336 – 348 | Nuclear localization signalBy similarityAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the CAF1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 323 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1990, Eukaryota |
GeneTreei | ENSGT00940000153167 |
HOGENOMi | CLU_044804_1_0_1 |
InParanoidi | Q9D2E2 |
OMAi | FSAFGWC |
OrthoDBi | 1402758at2759 |
PhylomeDBi | Q9D2E2 |
TreeFami | TF314502 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR006941, RNase_CAF1 IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR000571, Znf_CCCH |
Pfami | View protein in Pfam PF04857, CAF1, 2 hits PF00642, zf-CCCH, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9D2E2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS
60 70 80 90 100
LLLALKTASF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL
110 120 130 140 150
GLACFRQQPD KGENSYLAQV FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR
160 170 180 190 200
QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY
210 220 230 240 250
QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK
260 270 280 290 300
CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI
310 320 330 340 350
CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRSL
360 370 380 390 400
QSQPGTQTLA EAEDGPPTKQ VCEDSLETEK MEQKVAEGEA GDQPGSREGH
410 420 430 440 450
TSSLEMAHRR TSAETADVAT SELLVNQAST NPVPGDGLHR AGFDAFMTGY
460 470 480 490 500
VMAYVGLSQG LQLCSSEPWL PECHNKVYLS GKTVPLTVTK SQFSRPSKAH
510
NQKMKLAWGS S
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6ZMT3 | F6ZMT3_MOUSE | Target of EGR1 protein 1 | Toe1 | 188 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | D → G in AAH23109 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 15 | P → S in AAH23109 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 26 | P → S in AAH23109 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 128 | I → M in AAH23109 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 182 | R → W in BAB30482 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 278 | S → R in AAH23109 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 360 | A → V in AAH23109 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022242 | 306 – 329 | AYGWC…IIDTD → HTRSRFTGQLWETTIFPVEK LKDI in isoform 2. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_022243 | 330 – 511 | Missing in isoform 2. 1 PublicationAdd BLAST | 182 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016889 mRNA Translation: BAB30482.1 AK019829 mRNA Translation: BAB31871.1 AK046576 mRNA Translation: BAC32792.1 AK082975 mRNA Translation: BAC38718.1 AK148609 mRNA Translation: BAE28623.1 BC023109 mRNA Translation: AAH23109.1 |
CCDSi | CCDS18517.1 [Q9D2E2-1] |
RefSeqi | NP_080930.1, NM_026654.2 [Q9D2E2-1] |
Genome annotation databases
Ensembli | ENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1] ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2] |
GeneIDi | 68276 |
KEGGi | mmu:68276 |
UCSCi | uc008uhk.1, mouse [Q9D2E2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016889 mRNA Translation: BAB30482.1 AK019829 mRNA Translation: BAB31871.1 AK046576 mRNA Translation: BAC32792.1 AK082975 mRNA Translation: BAC38718.1 AK148609 mRNA Translation: BAE28623.1 BC023109 mRNA Translation: AAH23109.1 |
CCDSi | CCDS18517.1 [Q9D2E2-1] |
RefSeqi | NP_080930.1, NM_026654.2 [Q9D2E2-1] |
3D structure databases
SMRi | Q9D2E2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212779, 2 interactors |
IntActi | Q9D2E2, 2 interactors |
STRINGi | 10090.ENSMUSP00000030451 |
PTM databases
iPTMneti | Q9D2E2 |
PhosphoSitePlusi | Q9D2E2 |
Proteomic databases
EPDi | Q9D2E2 |
jPOSTi | Q9D2E2 |
PaxDbi | Q9D2E2 |
PeptideAtlasi | Q9D2E2 |
PRIDEi | Q9D2E2 |
Protocols and materials databases
Antibodypediai | 18606, 178 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1] ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2] |
GeneIDi | 68276 |
KEGGi | mmu:68276 |
UCSCi | uc008uhk.1, mouse [Q9D2E2-1] |
Organism-specific databases
CTDi | 114034 |
MGIi | MGI:1915526, Toe1 |
Phylogenomic databases
eggNOGi | KOG1990, Eukaryota |
GeneTreei | ENSGT00940000153167 |
HOGENOMi | CLU_044804_1_0_1 |
InParanoidi | Q9D2E2 |
OMAi | FSAFGWC |
OrthoDBi | 1402758at2759 |
PhylomeDBi | Q9D2E2 |
TreeFami | TF314502 |
Miscellaneous databases
BioGRID-ORCSi | 68276, 8 hits in 18 CRISPR screens |
ChiTaRSi | Toe1, mouse |
PROi | PR:Q9D2E2 |
RNActi | Q9D2E2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028688, Expressed in humerus cartilage element and 271 other tissues |
ExpressionAtlasi | Q9D2E2, baseline and differential |
Genevisiblei | Q9D2E2, MM |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR006941, RNase_CAF1 IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR000571, Znf_CCCH |
Pfami | View protein in Pfam PF04857, CAF1, 2 hits PF00642, zf-CCCH, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TOE1_MOUSE | |
Accessioni | Q9D2E2Primary (citable) accession number: Q9D2E2 Secondary accession number(s): Q3UFD8, Q8R5A4, Q9D412 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families