UniProtKB - Q9D2E2 (TOE1_MOUSE)

BLAST

>sp|Q9D2E2|TOE1_MOUSE Target of EGR1 protein 1 OS=Mus musculus OX=10090 GN=Toe1 PE=1 SV=1
MAADSDDDVPPVPTPSDGGVNKNTQPAEEFVVRVPVVDVQSDNFKEIWPSLLLALKTASF
VAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSVLSLGLACFRQQPDKGENSYLAQV
FNLTLLCIEEYVIEPKSVQFLVQHGFNFNRQYAQGIPYHKGNDKGDESQSQSVRTLFLEL
IRARRPLVLHNGLIDLVFLYQNFYAHLPENLGTFTADLCEMFPAGIYDTKYAAEFHARFV
ASYLEYAFRKCERENGKQRAAGSPHLALEFCSYPSSMSGHIDYRCCMSPGTCRRSRTTGI
CDKFSAYGWCPLGPQCPQSHDIDLIIDTDEAVAEDKRRRRRRKDKRKRSLQSQPGTQTLA
EAEDGPPTKQVCEDSLETEKMEQKVAEGEAGDQPGSREGHTSSLEMAHRRTSAETADVAT
SELLVNQASTNPVPGDGLHRAGFDAFMTGYVMAYVGLSQGLQLCSSEPWLPECHNKVYLS
GKTVPLTVTKSQFSRPSKAHNQKMKLAWGSS

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History
Entry version 119 (07 Nov 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Target of EGR1 protein 1

Gene

Toe1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 323	C3H1-typePROSITE-ProRule annotationAdd BLAST		29

GO - Molecular functionⁱ

3'-5'-exoribonuclease activity Source: MGI
metal ion binding Source: UniProtKB-KW
poly(A)-specific ribonuclease activity Source: MGI
snRNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

RNA phosphodiester bond hydrolysis, exonucleolytic Source: MGI
snRNA 3'-end processing Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Target of EGR1 protein 1
Gene namesⁱ	Name:Toe1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1915526 Toe1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000270834	2 – 511	Target of EGR1 protein 1Add BLAST		510

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	5	PhosphoserineBy similarity	1
Modified residueⁱ	349	PhosphoserineCombined sources	1
Modified residueⁱ	429	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9D2E2
PaxDbⁱ	Q9D2E2
PeptideAtlas More...PeptideAtlasⁱ	Q9D2E2
PRIDEⁱ	Q9D2E2

PTM databases

iPTMnetⁱ	Q9D2E2
PhosphoSitePlusⁱ	Q9D2E2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028688 Expressed in 252 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_TOE1
ExpressionAtlasⁱ	Q9D2E2 baseline and differential
Genevisibleⁱ	Q9D2E2 MM

Interactionⁱ

Subunit structureⁱ

Interacts with U1, U2, U4, U5 and U6 snRNAs.By similarity

Protein-protein interaction databases

IntActⁱ	Q9D2E2, 2 interactors
STRINGⁱ	10090.ENSMUSP00000030451

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D2E2
SMRⁱ	Q9D2E2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	336 – 348	Nuclear localization signalBy similarityAdd BLAST		13

Sequence similaritiesⁱ

Belongs to the CAF1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 323	C3H1-typePROSITE-ProRule annotationAdd BLAST		29

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IR2Y Eukaryota ENOG410XNUS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004077
HOGENOMⁱ	HOG000231417
HOVERGENⁱ	HBG080270
InParanoidⁱ	Q9D2E2
KEGG Orthology (KO) More...KOⁱ	K13202
OMAⁱ	GTHRAGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L18
PhylomeDBⁱ	Q9D2E2
TreeFamⁱ	TF314502

Family and domain databases

Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR006941 RNase_CAF1 IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf IPR000571 Znf_CCCH
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04857 CAF1, 2 hits PF00642 zf-CCCH, 1 hit
SUPFAMⁱ	SSF53098 SSF53098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9D2E2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS 
        60         70         80         90        100
LLLALKTASF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL 
       110        120        130        140        150
GLACFRQQPD KGENSYLAQV FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR 
       160        170        180        190        200
QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY 
       210        220        230        240        250
QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK 
       260        270        280        290        300
CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI 
       310        320        330        340        350
CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRSL 
       360        370        380        390        400
QSQPGTQTLA EAEDGPPTKQ VCEDSLETEK MEQKVAEGEA GDQPGSREGH 
       410        420        430        440        450
TSSLEMAHRR TSAETADVAT SELLVNQAST NPVPGDGLHR AGFDAFMTGY 
       460        470        480        490        500
VMAYVGLSQG LQLCSSEPWL PECHNKVYLS GKTVPLTVTK SQFSRPSKAH 
       510 
NQKMKLAWGS S

Length:511

Mass (Da):56,871

Last modified:June 1, 2001 - v1

Checksum:ⁱB7E9946A352BED90

Isoform 2 (identifier: Q9D2E2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
306-329: AYGWCPLGPQCPQSHDIDLIIDTD → HTRSRFTGQLWETTIFPVEKLKDI
330-511: Missing.

« Hide

        10         20         30         40         50
MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS 
        60         70         80         90        100
LLLALKTASF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL 
       110        120        130        140        150
GLACFRQQPD KGENSYLAQV FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR 
       160        170        180        190        200
QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY 
       210        220        230        240        250
QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK 
       260        270        280        290        300
CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI 
       310        320 
CDKFSHTRSR FTGQLWETTI FPVEKLKDI

Note: No experimental confirmation available.

Show »

Length:329

Mass (Da):37,149

Checksum:ⁱ09D4313BD4E6C3FD

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6ZMT3	F6ZMT3_MOUSE		Target of EGR1 protein 1 Target of EGR1 protein 1	Toe1	188	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	D → G in AAH23109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	15	P → S in AAH23109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	26	P → S in AAH23109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	128	I → M in AAH23109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	182	R → W in BAB30482 (PubMed:16141072).Curated	1
Sequence conflictⁱ	278	S → R in AAH23109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	360	A → V in AAH23109 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_022242	306 – 329	AYGWC…IIDTD → HTRSRFTGQLWETTIFPVEK LKDI in isoform 2. 1 PublicationAdd BLAST		24
Alternative sequenceⁱVSP_022243	330 – 511	Missing in isoform 2. 1 PublicationAdd BLAST		182

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK016889 mRNA Translation: BAB30482.1 AK019829 mRNA Translation: BAB31871.1 AK046576 mRNA Translation: BAC32792.1 AK082975 mRNA Translation: BAC38718.1 AK148609 mRNA Translation: BAE28623.1 BC023109 mRNA Translation: AAH23109.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18517.1 [Q9D2E2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_080930.1, NM_026654.2 [Q9D2E2-1]
UniGeneⁱ	Mm.30534

Genome annotation databases

Ensemblⁱ	ENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1] ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2]
GeneIDⁱ	68276
KEGGⁱ	mmu:68276
UCSC genome browser More...UCSCⁱ	uc008uhk.1 mouse [Q9D2E2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9D2E2	Target of EGR1 protein 1	)	HUMAN		510	UniRef50_Q96GM8
Target of EGR1 protein 1		PONAB		510
Target of EGR1 protein 1		BOVIN		524
Uncharacterized protein		RHIBE		525
Uncharacterized protein		SAIBB		525
+267
Q9D2E2-2	Target of EGR1, exonuclease		GASAC		305	UniRef50_Q9D2E2-2
Uncharacterized protein		PELSI		283
Target of EGR1 protein 1		FUNHE		329
UPI000A31402F		MUSPA		329

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK016889 mRNA Translation: BAB30482.1 AK019829 mRNA Translation: BAB31871.1 AK046576 mRNA Translation: BAC32792.1 AK082975 mRNA Translation: BAC38718.1 AK148609 mRNA Translation: BAE28623.1 BC023109 mRNA Translation: AAH23109.1
CCDSⁱ	CCDS18517.1 [Q9D2E2-1]
RefSeqⁱ	NP_080930.1, NM_026654.2 [Q9D2E2-1]
UniGeneⁱ	Mm.30534

3D structure databases

ProteinModelPortalⁱ	Q9D2E2
SMRⁱ	Q9D2E2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9D2E2, 2 interactors
STRINGⁱ	10090.ENSMUSP00000030451

PTM databases

iPTMnetⁱ	Q9D2E2
PhosphoSitePlusⁱ	Q9D2E2

Proteomic databases

EPDⁱ	Q9D2E2
PaxDbⁱ	Q9D2E2
PeptideAtlasⁱ	Q9D2E2
PRIDEⁱ	Q9D2E2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030451; ENSMUSP00000030451; ENSMUSG00000028688 [Q9D2E2-1] ENSMUST00000106455; ENSMUSP00000102063; ENSMUSG00000028688 [Q9D2E2-2]
GeneIDⁱ	68276
KEGGⁱ	mmu:68276
UCSCⁱ	uc008uhk.1 mouse [Q9D2E2-1]

Organism-specific databases

CTDⁱ	114034
MGIⁱ	MGI:1915526 Toe1

Phylogenomic databases

eggNOGⁱ	ENOG410IR2Y Eukaryota ENOG410XNUS LUCA
GeneTreeⁱ	ENSGT00390000004077
HOGENOMⁱ	HOG000231417
HOVERGENⁱ	HBG080270
InParanoidⁱ	Q9D2E2
KOⁱ	K13202
OMAⁱ	GTHRAGF
OrthoDBⁱ	EOG091G0L18
PhylomeDBⁱ	Q9D2E2
TreeFamⁱ	TF314502

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9D2E2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028688 Expressed in 252 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_TOE1
ExpressionAtlasⁱ	Q9D2E2 baseline and differential
Genevisibleⁱ	Q9D2E2 MM

Family and domain databases

Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR006941 RNase_CAF1 IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf IPR000571 Znf_CCCH
Pfamⁱ	View protein in Pfam PF04857 CAF1, 2 hits PF00642 zf-CCCH, 1 hit
SUPFAMⁱ	SSF53098 SSF53098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOE1_MOUSE
Accessionⁱ	Q9D2E2Primary (citable) accession number: Q9D2E2 Secondary accession number(s): Q3UFD8, Q8R5A4, Q9D412
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9D2E2 (TOE1_MOUSE)

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Target of EGR1 protein 1

Toe1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ