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Protein

Kelch domain-containing protein 8B

Gene

Klhdc8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 8B
Gene namesi
Name:Klhdc8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925517 Klhdc8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191321 – 354Kelch domain-containing protein 8BAdd BLAST354

Proteomic databases

MaxQBiQ9D2D9
PaxDbiQ9D2D9
PRIDEiQ9D2D9

PTM databases

PhosphoSitePlusiQ9D2D9

Expressioni

Gene expression databases

BgeeiENSMUSG00000032609 Expressed in 199 organ(s), highest expression level in dorsal pancreas
CleanExiMM_KLHDC8B
ExpressionAtlasiQ9D2D9 baseline and differential
GenevisibleiQ9D2D9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035232

Structurei

3D structure databases

ProteinModelPortaliQ9D2D9
SMRiQ9D2D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31Kelch 1Add BLAST31
Repeati32 – 79Kelch 2Add BLAST48
Repeati81 – 127Kelch 3Add BLAST47
Repeati128 – 175Kelch 4Add BLAST48
Repeati176 – 222Kelch 5Add BLAST47
Repeati224 – 281Kelch 6Add BLAST58
Repeati282 – 329Kelch 7Add BLAST48
Repeati331 – 354Kelch 8Add BLAST24

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00910000144191
HOGENOMiHOG000065733
HOVERGENiHBG055245
InParanoidiQ9D2D9
OMAiMPTCRVY
OrthoDBiEOG091G08A7
PhylomeDBiQ9D2D9

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF01344 Kelch_1, 4 hits
SMARTiView protein in SMART
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D2D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGGRAFA WQVFPPMPTC RVYGTVAHQD GHLLVLGGCG RAGLPLDTAE
60 70 80 90 100
TLDMGSHTWL ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF
110 120 130 140 150
LADEGRWERR ATLPQAAMGV ATVERDGMVY ALGGMGPDTA PQAQVLVYEP
160 170 180 190 200
RRDCWLSLPS MPTPCYGAST FLHGNKIYVL GGRQGKLPVT AFEAFDLETR
210 220 230 240 250
TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS RPHFVNTVEM
260 270 280 290 300
FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GNIVAIGGLG NQPCPLASVE
310 320 330 340 350
SFSLARRRWE VLPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL

RDGV
Length:354
Mass (Da):37,592
Last modified:June 1, 2001 - v1
Checksum:iC4C6D88B61A4FDC5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWH8A0A0A6YWH8_MOUSE
Kelch domain-containing protein 8B
Klhdc8b
308Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019849 mRNA Translation: BAB31879.1
AK154428 mRNA Translation: BAE32579.1
BC048918 mRNA Translation: AAH48918.1
CCDSiCCDS23526.1
RefSeqiNP_084351.1, NM_030075.2
XP_017169186.1, XM_017313697.1
UniGeneiMm.283194

Genome annotation databases

EnsembliENSMUST00000035232; ENSMUSP00000035232; ENSMUSG00000032609
ENSMUST00000193286; ENSMUSP00000142325; ENSMUSG00000032609
ENSMUST00000193895; ENSMUSP00000141453; ENSMUSG00000032609
GeneIDi78267
KEGGimmu:78267
UCSCiuc009rpo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019849 mRNA Translation: BAB31879.1
AK154428 mRNA Translation: BAE32579.1
BC048918 mRNA Translation: AAH48918.1
CCDSiCCDS23526.1
RefSeqiNP_084351.1, NM_030075.2
XP_017169186.1, XM_017313697.1
UniGeneiMm.283194

3D structure databases

ProteinModelPortaliQ9D2D9
SMRiQ9D2D9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035232

PTM databases

PhosphoSitePlusiQ9D2D9

Proteomic databases

MaxQBiQ9D2D9
PaxDbiQ9D2D9
PRIDEiQ9D2D9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035232; ENSMUSP00000035232; ENSMUSG00000032609
ENSMUST00000193286; ENSMUSP00000142325; ENSMUSG00000032609
ENSMUST00000193895; ENSMUSP00000141453; ENSMUSG00000032609
GeneIDi78267
KEGGimmu:78267
UCSCiuc009rpo.1 mouse

Organism-specific databases

CTDi200942
MGIiMGI:1925517 Klhdc8b

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00910000144191
HOGENOMiHOG000065733
HOVERGENiHBG055245
InParanoidiQ9D2D9
OMAiMPTCRVY
OrthoDBiEOG091G08A7
PhylomeDBiQ9D2D9

Miscellaneous databases

PROiPR:Q9D2D9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032609 Expressed in 199 organ(s), highest expression level in dorsal pancreas
CleanExiMM_KLHDC8B
ExpressionAtlasiQ9D2D9 baseline and differential
GenevisibleiQ9D2D9 MM

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF01344 Kelch_1, 4 hits
SMARTiView protein in SMART
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLD8B_MOUSE
AccessioniPrimary (citable) accession number: Q9D2D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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