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Protein

Zinc finger protein 687

Gene

Znf687

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri964 – 987C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri994 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 687
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf687
Synonyms:Kiaa1441, Zfp687
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1925516 Zfp687

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340061 – 1237Zinc finger protein 687Add BLAST1237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104PhosphoserineCombined sources1
Modified residuei142PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei254PhosphoserineCombined sources1
Modified residuei266PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei374PhosphoserineBy similarity1
Modified residuei377PhosphothreonineBy similarity1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei433PhosphoserineCombined sources1
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki451Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki464Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei495PhosphoserineBy similarity1
Modified residuei901PhosphothreonineBy similarity1
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1044Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1061Omega-N-methylarginineCombined sources1
Modified residuei1083PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1086PhosphoserineBy similarity1
Modified residuei1102Omega-N-methylarginineCombined sources1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1211PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9D2D7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9D2D7

PeptideAtlas

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PeptideAtlasi
Q9D2D7

PRoteomics IDEntifications database

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PRIDEi
Q9D2D7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9D2D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9D2D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000019338 Expressed in 247 organ(s), highest expression level in dorsal pancreas

CleanEx database of gene expression profiles

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CleanExi
MM_ZFP687

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9D2D7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9D2D7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
219291, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000019482

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9D2D7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9D2D7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 60Poly-Ala4
Compositional biasi172 – 304Pro-richAdd BLAST133
Compositional biasi321 – 325Poly-Ser5
Compositional biasi956 – 963Poly-Gly8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri964 – 987C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri994 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010306

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062228

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9D2D7

Identification of Orthologs from Complete Genome Data

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OMAi
FISHKKK

Database of Orthologous Groups

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OrthoDBi
180681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D2D7

TreeFam database of animal gene trees

More...
TreeFami
TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD IDANEAIHSG PEENEGPGGQ GKPEPSVGGD
60 70 80 90 100
SKDREEAAAA ENDPESPAEA SDHGLPQPPD TSTVSVIVKN TVCPEQSESL
110 120 130 140 150
TGDSGEEETK AGGITKEGPV GSCLMQNGFG GPEPSLSENP HSSAHASGNA
160 170 180 190 200
WKDKAVEGKT CLDLFAHFGS EPGDHPDPLP PEPSQPRGGD MAPPPFSTPF
210 220 230 240 250
ELAPENGSTL LPPASLLPQG ALKQESCSPH HSQGLTQRGP GSSPETAGIP
260 270 280 290 300
ASVSPPQVAG VSFKQSPGHQ SPPASPVKAP SCKPLKEEDE GTVDKSPPRS
310 320 330 340 350
PQSPSSGAEA ADEDSNDSPT SSSSSRPLKV RIKTIKTSCG NITRTVTRVP
360 370 380 390 400
SEPDPPAPLA EGAFLAETSF LKLSPVTPTP EGPKVVSVQL GDGTRLKGTV
410 420 430 440 450
LPVATIQNAS TAMLMAASVA RKAVVLPGGN ATSPKTMTKS VLGLVPQTLP
460 470 480 490 500
KAEVRTGFSL GGQKVNGASV VMVQPSKSAT GPGTAGGSVI SRTQSSLVEA
510 520 530 540 550
FNKILNSKNL LPAYRPNLSP PAEAGLALPP TGYRCLECGD AFSLEKSLAR
560 570 580 590 600
HYDRRSMRIE VTCNHCARRL VFFNKCSLLL HAREHKDKGL VMQCSHLVMR
610 620 630 640 650
PVALDQMVGQ PDITPLLPVA VPPVPGPLAL PVLGKGEGAV TSSTITTVAT
660 670 680 690 700
EAPVLPLPTE PPAPPTASVY TCFRCLECKE QCRDKAGMAA HFQQLGPPAL
710 720 730 740 750
GSTSNVCPSC PMMLPNRCSF SAHQRTHKNR APHVCPECGG NFLQANFQTH
760 770 780 790 800
LREACLHFSR RVGYRCPSCA VVFGGVNSIK SHIQASHCEV FHKCPICPMA
810 820 830 840 850
FKSAPSAHAH LYSQHPSFLT QQAKLIYKCA MCDTVFTHKP LLSSHFDQHL
860 870 880 890 900
LPQRVSVFKC PSCPLLFAQK RTMLEHLKNT HQSGRVGEEA VGKGAGGALL
910 920 930 940 950
TPKTEPEELA VSQAEAAPAT EESSSSSEEE LPSSPEPPRP TKRARRGELG
960 970 980 990 1000
NKGIKGGGGG PGGWTCGLCH SWCPERDEYV THMKKEHGKS VKKFPCRLCE
1010 1020 1030 1040 1050
RSFCSAPSLR RHVRVNHEGI KRVYPCRYCT EGKRTFSSRL ILEKHVQVRH
1060 1070 1080 1090 1100
GLPLGTQSSG RGGSLARGSG GRAQGPGRKR RQSSDSCSEE PDSTTPPAKS
1110 1120 1130 1140 1150
LRGGPGSGGH GPLRYRSSGS AEQSLVGLRV DGGTQQCLDC GLCFASPGSL
1160 1170 1180 1190 1200
SRHRFISHKK RRAGGKASVL GLGDGEEAAP PLRSDPEGGD SPLPAPGDPL
1210 1220 1230
TCKVCGKSCD SPLNLKTHFR THGMAFIRAR QGGSGDN
Length:1,237
Mass (Da):130,350
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61016AFB31FE90D0
GO
Isoform 2 (identifier: Q9D2D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-786: CPSCAVVFGGVNSIKSHIQAS → TLTSLDVWGKRQLGKGLEVPF
     787-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:786
Mass (Da):82,207
Checksum:i9DAC34E904D50912
GO
Isoform 3 (identifier: Q9D2D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     767-775: PSCAVVFGG → LMLNSSLEL
     776-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):80,985
Checksum:iF4A9A2B96233A73E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z524D3Z524_MOUSE
Zinc finger protein 687
Zfp687
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z717D3Z717_MOUSE
Zinc finger protein 687
Zfp687
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2E5D3Z2E5_MOUSE
Zinc finger protein 687
Zfp687
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018170766 – 786CPSCA…HIQAS → TLTSLDVWGKRQLGKGLEVP F in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_018171767 – 775PSCAVVFGG → LMLNSSLEL in isoform 3. 1 Publication9
Alternative sequenceiVSP_018172776 – 1237Missing in isoform 3. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_018173787 – 1237Missing in isoform 2. 1 PublicationAdd BLAST451

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK019851 mRNA Translation: BAB31881.1
BC056943 mRNA Translation: AAH56943.1
BC060179 mRNA Translation: AAH60179.1
AK129360 mRNA Translation: BAC98170.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17600.1 [Q9D2D7-1]

NCBI Reference Sequences

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RefSeqi
NP_084350.1, NM_030074.2 [Q9D2D7-1]
XP_006502370.1, XM_006502307.3 [Q9D2D7-1]
XP_006502371.1, XM_006502308.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.389478
Mm.418161

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000019482; ENSMUSP00000019482; ENSMUSG00000019338 [Q9D2D7-1]
ENSMUST00000137799; ENSMUSP00000123335; ENSMUSG00000019338 [Q9D2D7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
78266

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:78266

UCSC genome browser

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UCSCi
uc008qhp.1 mouse [Q9D2D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019851 mRNA Translation: BAB31881.1
BC056943 mRNA Translation: AAH56943.1
BC060179 mRNA Translation: AAH60179.1
AK129360 mRNA Translation: BAC98170.1
CCDSiCCDS17600.1 [Q9D2D7-1]
RefSeqiNP_084350.1, NM_030074.2 [Q9D2D7-1]
XP_006502370.1, XM_006502307.3 [Q9D2D7-1]
XP_006502371.1, XM_006502308.1
UniGeneiMm.389478
Mm.418161

3D structure databases

ProteinModelPortaliQ9D2D7
SMRiQ9D2D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219291, 3 interactors
STRINGi10090.ENSMUSP00000019482

PTM databases

iPTMnetiQ9D2D7
PhosphoSitePlusiQ9D2D7

Proteomic databases

EPDiQ9D2D7
PaxDbiQ9D2D7
PeptideAtlasiQ9D2D7
PRIDEiQ9D2D7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019482; ENSMUSP00000019482; ENSMUSG00000019338 [Q9D2D7-1]
ENSMUST00000137799; ENSMUSP00000123335; ENSMUSG00000019338 [Q9D2D7-2]
GeneIDi78266
KEGGimmu:78266
UCSCiuc008qhp.1 mouse [Q9D2D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
78266
MGIiMGI:1925516 Zfp687

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156524
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ9D2D7
OMAiFISHKKK
OrthoDBi180681at2759
PhylomeDBiQ9D2D7
TreeFamiTF329009

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9D2D7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019338 Expressed in 247 organ(s), highest expression level in dorsal pancreas
CleanExiMM_ZFP687
ExpressionAtlasiQ9D2D7 baseline and differential
GenevisibleiQ9D2D7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN687_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D2D7
Secondary accession number(s): Q6PAP3, Q6ZPQ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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