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Protein

Zinc finger protein 687

Gene

Znf687

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri964 – 987C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri994 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 687
Gene namesi
Name:Znf687
Synonyms:Kiaa1441, Zfp687
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925516 Zfp687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340061 – 1237Zinc finger protein 687Add BLAST1237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104PhosphoserineCombined sources1
Modified residuei142PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei254PhosphoserineCombined sources1
Modified residuei266PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei374PhosphoserineBy similarity1
Modified residuei377PhosphothreonineBy similarity1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei433PhosphoserineCombined sources1
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki451Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki464Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei495PhosphoserineBy similarity1
Modified residuei901PhosphothreonineBy similarity1
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1044Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1061Omega-N-methylarginineCombined sources1
Modified residuei1083PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1086PhosphoserineBy similarity1
Modified residuei1102Omega-N-methylarginineCombined sources1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1211PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D2D7
PaxDbiQ9D2D7
PeptideAtlasiQ9D2D7
PRIDEiQ9D2D7

PTM databases

iPTMnetiQ9D2D7
PhosphoSitePlusiQ9D2D7

Expressioni

Gene expression databases

BgeeiENSMUSG00000019338 Expressed in 247 organ(s), highest expression level in dorsal pancreas
CleanExiMM_ZFP687
ExpressionAtlasiQ9D2D7 baseline and differential
GenevisibleiQ9D2D7 MM

Interactioni

Protein-protein interaction databases

BioGridi219291, 3 interactors
STRINGi10090.ENSMUSP00000019482

Structurei

3D structure databases

ProteinModelPortaliQ9D2D7
SMRiQ9D2D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 60Poly-Ala4
Compositional biasi172 – 304Pro-richAdd BLAST133
Compositional biasi321 – 325Poly-Ser5
Compositional biasi956 – 963Poly-Gly8

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri533 – 552C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri705 – 727C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 787C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri792 – 815C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 849C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri858 – 881C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri964 – 987C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri994 – 1017C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1200 – 1222C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063261
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ9D2D7
OMAiFISHKKK
OrthoDBiEOG091G0AA1
PhylomeDBiQ9D2D7
TreeFamiTF329009

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D2D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD IDANEAIHSG PEENEGPGGQ GKPEPSVGGD
60 70 80 90 100
SKDREEAAAA ENDPESPAEA SDHGLPQPPD TSTVSVIVKN TVCPEQSESL
110 120 130 140 150
TGDSGEEETK AGGITKEGPV GSCLMQNGFG GPEPSLSENP HSSAHASGNA
160 170 180 190 200
WKDKAVEGKT CLDLFAHFGS EPGDHPDPLP PEPSQPRGGD MAPPPFSTPF
210 220 230 240 250
ELAPENGSTL LPPASLLPQG ALKQESCSPH HSQGLTQRGP GSSPETAGIP
260 270 280 290 300
ASVSPPQVAG VSFKQSPGHQ SPPASPVKAP SCKPLKEEDE GTVDKSPPRS
310 320 330 340 350
PQSPSSGAEA ADEDSNDSPT SSSSSRPLKV RIKTIKTSCG NITRTVTRVP
360 370 380 390 400
SEPDPPAPLA EGAFLAETSF LKLSPVTPTP EGPKVVSVQL GDGTRLKGTV
410 420 430 440 450
LPVATIQNAS TAMLMAASVA RKAVVLPGGN ATSPKTMTKS VLGLVPQTLP
460 470 480 490 500
KAEVRTGFSL GGQKVNGASV VMVQPSKSAT GPGTAGGSVI SRTQSSLVEA
510 520 530 540 550
FNKILNSKNL LPAYRPNLSP PAEAGLALPP TGYRCLECGD AFSLEKSLAR
560 570 580 590 600
HYDRRSMRIE VTCNHCARRL VFFNKCSLLL HAREHKDKGL VMQCSHLVMR
610 620 630 640 650
PVALDQMVGQ PDITPLLPVA VPPVPGPLAL PVLGKGEGAV TSSTITTVAT
660 670 680 690 700
EAPVLPLPTE PPAPPTASVY TCFRCLECKE QCRDKAGMAA HFQQLGPPAL
710 720 730 740 750
GSTSNVCPSC PMMLPNRCSF SAHQRTHKNR APHVCPECGG NFLQANFQTH
760 770 780 790 800
LREACLHFSR RVGYRCPSCA VVFGGVNSIK SHIQASHCEV FHKCPICPMA
810 820 830 840 850
FKSAPSAHAH LYSQHPSFLT QQAKLIYKCA MCDTVFTHKP LLSSHFDQHL
860 870 880 890 900
LPQRVSVFKC PSCPLLFAQK RTMLEHLKNT HQSGRVGEEA VGKGAGGALL
910 920 930 940 950
TPKTEPEELA VSQAEAAPAT EESSSSSEEE LPSSPEPPRP TKRARRGELG
960 970 980 990 1000
NKGIKGGGGG PGGWTCGLCH SWCPERDEYV THMKKEHGKS VKKFPCRLCE
1010 1020 1030 1040 1050
RSFCSAPSLR RHVRVNHEGI KRVYPCRYCT EGKRTFSSRL ILEKHVQVRH
1060 1070 1080 1090 1100
GLPLGTQSSG RGGSLARGSG GRAQGPGRKR RQSSDSCSEE PDSTTPPAKS
1110 1120 1130 1140 1150
LRGGPGSGGH GPLRYRSSGS AEQSLVGLRV DGGTQQCLDC GLCFASPGSL
1160 1170 1180 1190 1200
SRHRFISHKK RRAGGKASVL GLGDGEEAAP PLRSDPEGGD SPLPAPGDPL
1210 1220 1230
TCKVCGKSCD SPLNLKTHFR THGMAFIRAR QGGSGDN
Length:1,237
Mass (Da):130,350
Last modified:June 1, 2001 - v1
Checksum:i61016AFB31FE90D0
GO
Isoform 2 (identifier: Q9D2D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-786: CPSCAVVFGGVNSIKSHIQAS → TLTSLDVWGKRQLGKGLEVPF
     787-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:786
Mass (Da):82,207
Checksum:i9DAC34E904D50912
GO
Isoform 3 (identifier: Q9D2D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     767-775: PSCAVVFGG → LMLNSSLEL
     776-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):80,985
Checksum:iF4A9A2B96233A73E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z524D3Z524_MOUSE
Zinc finger protein 687
Zfp687
206Annotation score:
D3Z717D3Z717_MOUSE
Zinc finger protein 687
Zfp687
163Annotation score:
D3Z2E5D3Z2E5_MOUSE
Zinc finger protein 687
Zfp687
95Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018170766 – 786CPSCA…HIQAS → TLTSLDVWGKRQLGKGLEVP F in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_018171767 – 775PSCAVVFGG → LMLNSSLEL in isoform 3. 1 Publication9
Alternative sequenceiVSP_018172776 – 1237Missing in isoform 3. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_018173787 – 1237Missing in isoform 2. 1 PublicationAdd BLAST451

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019851 mRNA Translation: BAB31881.1
BC056943 mRNA Translation: AAH56943.1
BC060179 mRNA Translation: AAH60179.1
AK129360 mRNA Translation: BAC98170.1
CCDSiCCDS17600.1 [Q9D2D7-1]
RefSeqiNP_084350.1, NM_030074.2 [Q9D2D7-1]
XP_006502370.1, XM_006502307.3 [Q9D2D7-1]
XP_006502371.1, XM_006502308.1
UniGeneiMm.389478
Mm.418161

Genome annotation databases

EnsembliENSMUST00000019482; ENSMUSP00000019482; ENSMUSG00000019338 [Q9D2D7-1]
ENSMUST00000137799; ENSMUSP00000123335; ENSMUSG00000019338 [Q9D2D7-2]
GeneIDi78266
KEGGimmu:78266
UCSCiuc008qhp.1 mouse [Q9D2D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019851 mRNA Translation: BAB31881.1
BC056943 mRNA Translation: AAH56943.1
BC060179 mRNA Translation: AAH60179.1
AK129360 mRNA Translation: BAC98170.1
CCDSiCCDS17600.1 [Q9D2D7-1]
RefSeqiNP_084350.1, NM_030074.2 [Q9D2D7-1]
XP_006502370.1, XM_006502307.3 [Q9D2D7-1]
XP_006502371.1, XM_006502308.1
UniGeneiMm.389478
Mm.418161

3D structure databases

ProteinModelPortaliQ9D2D7
SMRiQ9D2D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219291, 3 interactors
STRINGi10090.ENSMUSP00000019482

PTM databases

iPTMnetiQ9D2D7
PhosphoSitePlusiQ9D2D7

Proteomic databases

EPDiQ9D2D7
PaxDbiQ9D2D7
PeptideAtlasiQ9D2D7
PRIDEiQ9D2D7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019482; ENSMUSP00000019482; ENSMUSG00000019338 [Q9D2D7-1]
ENSMUST00000137799; ENSMUSP00000123335; ENSMUSG00000019338 [Q9D2D7-2]
GeneIDi78266
KEGGimmu:78266
UCSCiuc008qhp.1 mouse [Q9D2D7-1]

Organism-specific databases

CTDi78266
MGIiMGI:1925516 Zfp687
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063261
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ9D2D7
OMAiFISHKKK
OrthoDBiEOG091G0AA1
PhylomeDBiQ9D2D7
TreeFamiTF329009

Miscellaneous databases

PROiPR:Q9D2D7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019338 Expressed in 247 organ(s), highest expression level in dorsal pancreas
CleanExiMM_ZFP687
ExpressionAtlasiQ9D2D7 baseline and differential
GenevisibleiQ9D2D7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN687_MOUSE
AccessioniPrimary (citable) accession number: Q9D2D7
Secondary accession number(s): Q6PAP3, Q6ZPQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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