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Protein

snRNA-activating protein complex subunit 3

Gene

Snapc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 3
Short name:
SNAPc subunit 3
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 3
Gene namesi
Name:Snapc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916338 Snapc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720261 – 407snRNA-activating protein complex subunit 3Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2C9
PRIDEiQ9D2C9

PTM databases

iPTMnetiQ9D2C9
PhosphoSitePlusiQ9D2C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028483 Expressed in 281 organ(s), highest expression level in lens of camera-type eye
ExpressionAtlasiQ9D2C9 baseline and differential
GenevisibleiQ9D2C9 MM

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030206

Structurei

3D structure databases

ProteinModelPortaliQ9D2C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAPC3/SRD2 family.Curated

Phylogenomic databases

eggNOGiKOG2664 Eukaryota
ENOG411090A LUCA
GeneTreeiENSGT00390000005708
HOGENOMiHOG000146435
HOVERGENiHBG071400
InParanoidiQ9D2C9
KOiK15210
OMAiQTAKMED
OrthoDBiEOG091G0BC6
TreeFamiTF317705

Family and domain databases

InterProiView protein in InterPro
IPR022042 snRNA-activating_su3
PANTHERiPTHR13421 PTHR13421, 1 hit
PfamiView protein in Pfam
PF12251 zf-SNAP50_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D2C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDLQGGGA GGPQHPVPSA SHSSFPEYEL PELHTRVFHV GSFGELWRGR
60 70 80 90 100
LGAQDLSLSE PQAAEQPTDG GASNDGFEDA AVASDLGCSL EAAAELRVVC
110 120 130 140 150
GLDKLRCLGE DEDPEVIPEN TDLVTLCVRK GLLDYREENI TIDRACRQEI
160 170 180 190 200
FAYEMESHAL GKKPENPADM IEEGECILSV NILYPVIFNK HKEHKPYQTM
210 220 230 240 250
LVLGSQKLTE LRDSICCVSD LQIGGEFSNA PDQAPEHISK DLYKSAFFYF
260 270 280 290 300
EGTFYNDRRY PECRDLSRTI IEWSESHDRG YGKFQTARME DFTFNDLHIK
310 320 330 340 350
LGFPYLYCHQ GDCEHVVVIT DIRLVHHDDC LDRTLYPLLT KKHWLWTRKC
360 370 380 390 400
FVCKMYTARW VTNNDTFAPE DPCFFCDVCF RMLHYDSEGN KLGEFLAYPY

VDPGTFN
Length:407
Mass (Da):46,277
Last modified:March 1, 2003 - v2
Checksum:i8BC79D553C7F5A7D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CQB0Q9CQB0_MOUSE
snRNA-activating protein complex su...
Snapc3
269Annotation score:
E0CY59E0CY59_MOUSE
snRNA-activating protein complex su...
Snapc3
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255Y → C in BAC27585 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019863 mRNA Translation: BAB31890.2
AK031870 mRNA Translation: BAC27585.1
AK049933 mRNA Translation: BAC33990.1
BC048713 mRNA Translation: AAH48713.1
CCDSiCCDS38792.1
RefSeqiNP_084225.1, NM_029949.3
XP_006538432.1, XM_006538369.3
XP_006538433.1, XM_006538370.3
XP_006538435.1, XM_006538372.3
XP_011248436.1, XM_011250134.2
XP_017175944.1, XM_017320455.1
XP_017175945.1, XM_017320456.1
UniGeneiMm.271985
Mm.482328

Genome annotation databases

EnsembliENSMUST00000030206; ENSMUSP00000030206; ENSMUSG00000028483
ENSMUST00000123262; ENSMUSP00000124038; ENSMUSG00000028483
ENSMUST00000124856; ENSMUSP00000124181; ENSMUSG00000028483
ENSMUST00000143533; ENSMUSP00000123793; ENSMUSG00000028483
GeneIDi77634
KEGGimmu:77634
UCSCiuc008tku.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019863 mRNA Translation: BAB31890.2
AK031870 mRNA Translation: BAC27585.1
AK049933 mRNA Translation: BAC33990.1
BC048713 mRNA Translation: AAH48713.1
CCDSiCCDS38792.1
RefSeqiNP_084225.1, NM_029949.3
XP_006538432.1, XM_006538369.3
XP_006538433.1, XM_006538370.3
XP_006538435.1, XM_006538372.3
XP_011248436.1, XM_011250134.2
XP_017175944.1, XM_017320455.1
XP_017175945.1, XM_017320456.1
UniGeneiMm.271985
Mm.482328

3D structure databases

ProteinModelPortaliQ9D2C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030206

PTM databases

iPTMnetiQ9D2C9
PhosphoSitePlusiQ9D2C9

Proteomic databases

PaxDbiQ9D2C9
PRIDEiQ9D2C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030206; ENSMUSP00000030206; ENSMUSG00000028483
ENSMUST00000123262; ENSMUSP00000124038; ENSMUSG00000028483
ENSMUST00000124856; ENSMUSP00000124181; ENSMUSG00000028483
ENSMUST00000143533; ENSMUSP00000123793; ENSMUSG00000028483
GeneIDi77634
KEGGimmu:77634
UCSCiuc008tku.1 mouse

Organism-specific databases

CTDi6619
MGIiMGI:1916338 Snapc3

Phylogenomic databases

eggNOGiKOG2664 Eukaryota
ENOG411090A LUCA
GeneTreeiENSGT00390000005708
HOGENOMiHOG000146435
HOVERGENiHBG071400
InParanoidiQ9D2C9
KOiK15210
OMAiQTAKMED
OrthoDBiEOG091G0BC6
TreeFamiTF317705

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRSiSnapc3 mouse
PROiPR:Q9D2C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028483 Expressed in 281 organ(s), highest expression level in lens of camera-type eye
ExpressionAtlasiQ9D2C9 baseline and differential
GenevisibleiQ9D2C9 MM

Family and domain databases

InterProiView protein in InterPro
IPR022042 snRNA-activating_su3
PANTHERiPTHR13421 PTHR13421, 1 hit
PfamiView protein in Pfam
PF12251 zf-SNAP50_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D2C9
Secondary accession number(s): Q8C0A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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