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Protein

Bax inhibitor 1

Gene

Tmbim6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (By similarity). Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971).By similarity1 Publication

GO - Molecular functioni

  • endoribonuclease inhibitor activity Source: ParkinsonsUK-UCL
  • enzyme binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy, Unfolded protein response
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Bax inhibitor 1
Short name:
BI-1
Alternative name(s):
Testis-enhanced gene transcript protein
Transmembrane BAX inhibitor motif-containing protein 6
Gene namesi
Name:Tmbim6
Synonyms:Tegt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99682 Tmbim6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 52LumenalSequence analysis2
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 86CytoplasmicSequence analysisAdd BLAST13
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 112LumenalSequence analysis5
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 166LumenalSequence analysis6
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 206CytoplasmicSequence analysisAdd BLAST19
Intramembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 237CytoplasmicSequence analysis10

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790791 – 237Bax inhibitor 1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9D2C7
PaxDbiQ9D2C7
PRIDEiQ9D2C7

PTM databases

iPTMnetiQ9D2C7
PhosphoSitePlusiQ9D2C7

Expressioni

Tissue specificityi

Highly abundant in adult testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000023010 Expressed in 266 organ(s), highest expression level in cochlea
ExpressionAtlasiQ9D2C7 baseline and differential
GenevisibleiQ9D2C7 MM

Interactioni

Subunit structurei

Interacts with BCL2 (By similarity). Interacts with BCL2L1 (PubMed:21926971).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D2C7, 1 interactor
STRINGi10090.ENSMUSP00000023749

Structurei

3D structure databases

ProteinModelPortaliQ9D2C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.By similarity

Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1629 Eukaryota
ENOG4111GCT LUCA
GeneTreeiENSGT00390000006722
HOGENOMiHOG000238748
HOVERGENiHBG001192
InParanoidiQ9D2C7
KOiK21889
OMAiPVRQHLK
OrthoDBiEOG091G0L75
PhylomeDBiQ9D2C7
TreeFamiTF323395

Family and domain databases

InterProiView protein in InterPro
IPR006213 Bax_inhbtr1_CS
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
PROSITEiView protein in PROSITE
PS01243 BI1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9D2C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHVV
60 70 80 90 100
THFIQAGLLS ALGSLALMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG
110 120 130 140 150
PALELCIAVN PSILPTAFMG TAMIFTCFSL SALYARRRSY LFLGGILMSA
160 170 180 190 200
MSLMLLSSLG NLFFGSIWLF QANLYLGLLV MCGFVLFDTQ LIIEKAEHGD
210 220 230
KDYIWHCVDL FLDFVTLFRK LMLILAFNEK DKKKEKK
Length:237
Mass (Da):26,478
Last modified:June 1, 2001 - v1
Checksum:i788E6EE7EB34AFFC
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX98E0CX98_MOUSE
Bax inhibitor 1
Tmbim6
235Annotation score:
E0CXR0E0CXR0_MOUSE
Bax inhibitor 1
Tmbim6
204Annotation score:
E0CZE8E0CZE8_MOUSE
Bax inhibitor 1
Tmbim6
32Annotation score:
A0A2R8W6Y1A0A2R8W6Y1_MOUSE
Bax inhibitor 1
Tmbim6
193Annotation score:
A0A2R8VI60A0A2R8VI60_MOUSE
Bax inhibitor 1
Tmbim6
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93F → Y in BAC29575 (PubMed:16141072).Curated1
Sequence conflicti93F → Y in BAC29662 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019865 mRNA Translation: BAB31892.1
AK036782 mRNA Translation: BAC29575.1
AK036994 mRNA Translation: BAC29662.1
AK049604 mRNA Translation: BAC33837.1
AK050299 mRNA Translation: BAC34174.1
AK050323 mRNA Translation: BAC34188.1
AK088030 mRNA Translation: BAC40107.1
AK088683 mRNA Translation: BAC40503.1
AK139901 mRNA Translation: BAE24176.1
AK159380 mRNA Translation: BAE35035.1
AK166935 mRNA Translation: BAE39128.1
BC005588 mRNA Translation: AAH05588.1
CCDSiCCDS37201.1
RefSeqiNP_001164505.1, NM_001171034.1
NP_001164506.1, NM_001171035.1
NP_001164507.1, NM_001171036.1
NP_080945.1, NM_026669.4
UniGeneiMm.16769

Genome annotation databases

EnsembliENSMUST00000023749; ENSMUSP00000023749; ENSMUSG00000023010
ENSMUST00000159209; ENSMUSP00000125117; ENSMUSG00000023010
ENSMUST00000159531; ENSMUSP00000125318; ENSMUSG00000023010
ENSMUST00000160635; ENSMUSP00000124651; ENSMUSG00000023010
ENSMUST00000161250; ENSMUSP00000125563; ENSMUSG00000023010
GeneIDi110213
KEGGimmu:110213
UCSCiuc007xpm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019865 mRNA Translation: BAB31892.1
AK036782 mRNA Translation: BAC29575.1
AK036994 mRNA Translation: BAC29662.1
AK049604 mRNA Translation: BAC33837.1
AK050299 mRNA Translation: BAC34174.1
AK050323 mRNA Translation: BAC34188.1
AK088030 mRNA Translation: BAC40107.1
AK088683 mRNA Translation: BAC40503.1
AK139901 mRNA Translation: BAE24176.1
AK159380 mRNA Translation: BAE35035.1
AK166935 mRNA Translation: BAE39128.1
BC005588 mRNA Translation: AAH05588.1
CCDSiCCDS37201.1
RefSeqiNP_001164505.1, NM_001171034.1
NP_001164506.1, NM_001171035.1
NP_001164507.1, NM_001171036.1
NP_080945.1, NM_026669.4
UniGeneiMm.16769

3D structure databases

ProteinModelPortaliQ9D2C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D2C7, 1 interactor
STRINGi10090.ENSMUSP00000023749

PTM databases

iPTMnetiQ9D2C7
PhosphoSitePlusiQ9D2C7

Proteomic databases

MaxQBiQ9D2C7
PaxDbiQ9D2C7
PRIDEiQ9D2C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023749; ENSMUSP00000023749; ENSMUSG00000023010
ENSMUST00000159209; ENSMUSP00000125117; ENSMUSG00000023010
ENSMUST00000159531; ENSMUSP00000125318; ENSMUSG00000023010
ENSMUST00000160635; ENSMUSP00000124651; ENSMUSG00000023010
ENSMUST00000161250; ENSMUSP00000125563; ENSMUSG00000023010
GeneIDi110213
KEGGimmu:110213
UCSCiuc007xpm.2 mouse

Organism-specific databases

CTDi7009
MGIiMGI:99682 Tmbim6

Phylogenomic databases

eggNOGiKOG1629 Eukaryota
ENOG4111GCT LUCA
GeneTreeiENSGT00390000006722
HOGENOMiHOG000238748
HOVERGENiHBG001192
InParanoidiQ9D2C7
KOiK21889
OMAiPVRQHLK
OrthoDBiEOG091G0L75
PhylomeDBiQ9D2C7
TreeFamiTF323395

Miscellaneous databases

ChiTaRSiTmbim6 mouse
PROiPR:Q9D2C7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023010 Expressed in 266 organ(s), highest expression level in cochlea
ExpressionAtlasiQ9D2C7 baseline and differential
GenevisibleiQ9D2C7 MM

Family and domain databases

InterProiView protein in InterPro
IPR006213 Bax_inhbtr1_CS
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
PROSITEiView protein in PROSITE
PS01243 BI1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D2C7
Secondary accession number(s): Q3TX81, Q8BFY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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