UniProtKB - Q9D275 (BATF3_MOUSE)
Basic leucine zipper transcriptional factor ATF-like 3
Batf3
Functioni
AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.
3 PublicationsMiscellaneous
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- dendritic cell differentiation Source: UniProtKB
- myeloid dendritic cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to virus Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper transcriptional factor ATF-like 3Short name: B-ATF-3 |
Gene namesi | Name:Batf3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1925491, Batf3 |
VEuPathDBi | HostDB:ENSMUSG00000026630 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326107 | 1 – 118 | Basic leucine zipper transcriptional factor ATF-like 3Add BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 24 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9D275 |
MaxQBi | Q9D275 |
PaxDbi | Q9D275 |
PRIDEi | Q9D275 |
ProteomicsDBi | 273729 |
PTM databases
iPTMneti | Q9D275 |
PhosphoSitePlusi | Q9D275 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000026630, Expressed in head and 175 other tissues |
Genevisiblei | Q9D275, MM |
Interactioni
Subunit structurei
Heterodimer; heterodimerizes with JUN family proteins.
Interacts with JUN.
Protein-protein interaction databases
BioGRIDi | 237877, 13 interactors |
IntActi | Q9D275, 13 interactors |
STRINGi | 10090.ENSMUSP00000027943 |
Miscellaneous databases
RNActi | Q9D275, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 91 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 69 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 30 – 55 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 56 – 84 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 47 – 69 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000161120 |
HOGENOMi | CLU_088612_1_1_1 |
InParanoidi | Q9D275 |
OMAi | TMNFVTI |
OrthoDBi | 1440552at2759 |
PhylomeDBi | Q9D275 |
TreeFami | TF332340 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029818, p21SNFT |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF13, PTHR23351:SF13, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSQGPPAVSV LQRSVDAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKADKLHEEH ESLEQENSVL RREISKLKEE LRHLSEVLKE HEKMCPLLLC
110
PMNFVQLRSD PVASCLPR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK020278 mRNA Translation: BAB32053.1 BC117083 mRNA Translation: AAI17084.1 BC117085 mRNA Translation: AAI17086.1 |
CCDSi | CCDS15615.1 |
RefSeqi | NP_084336.1, NM_030060.2 |
Genome annotation databases
Ensembli | ENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630 |
GeneIDi | 381319 |
KEGGi | mmu:381319 |
UCSCi | uc007ecd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK020278 mRNA Translation: BAB32053.1 BC117083 mRNA Translation: AAI17084.1 BC117085 mRNA Translation: AAI17086.1 |
CCDSi | CCDS15615.1 |
RefSeqi | NP_084336.1, NM_030060.2 |
3D structure databases
SMRi | Q9D275 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 237877, 13 interactors |
IntActi | Q9D275, 13 interactors |
STRINGi | 10090.ENSMUSP00000027943 |
PTM databases
iPTMneti | Q9D275 |
PhosphoSitePlusi | Q9D275 |
Proteomic databases
EPDi | Q9D275 |
MaxQBi | Q9D275 |
PaxDbi | Q9D275 |
PRIDEi | Q9D275 |
ProteomicsDBi | 273729 |
Protocols and materials databases
Antibodypediai | 34609, 148 antibodies from 22 providers |
DNASUi | 381319 |
Genome annotation databases
Ensembli | ENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630 |
GeneIDi | 381319 |
KEGGi | mmu:381319 |
UCSCi | uc007ecd.1, mouse |
Organism-specific databases
CTDi | 55509 |
MGIi | MGI:1925491, Batf3 |
VEuPathDBi | HostDB:ENSMUSG00000026630 |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000161120 |
HOGENOMi | CLU_088612_1_1_1 |
InParanoidi | Q9D275 |
OMAi | TMNFVTI |
OrthoDBi | 1440552at2759 |
PhylomeDBi | Q9D275 |
TreeFami | TF332340 |
Miscellaneous databases
BioGRID-ORCSi | 381319, 2 hits in 65 CRISPR screens |
ChiTaRSi | Batf3, mouse |
PROi | PR:Q9D275 |
RNActi | Q9D275, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026630, Expressed in head and 175 other tissues |
Genevisiblei | Q9D275, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029818, p21SNFT |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF13, PTHR23351:SF13, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BATF3_MOUSE | |
Accessioni | Q9D275Primary (citable) accession number: Q9D275 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families