Batf3

Functionⁱ

AP-1 family transcription factor that controls the differentiation of CD8⁺ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha⁺ classical dendritic cells (cDCs) and related CD103⁺ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.3 Publications

Miscellaneous

The increased protection toward L.monocytogenes infection in mice lacking Batf3 suggests that CD8-alpha⁺ classical dendritic cells (cDCs) and CD103⁺ dendritic cells are an entry point for infection by L.monocytogenes.1 Publication

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dendritic cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20351058
myeloid dendritic cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19008445
negative regulation of transcription by RNA polymerase II Source: MGI
response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19008445
- 20351058
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Differentiation, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Basic leucine zipper transcriptional factor ATF-like 3 Short name: B-ATF-3
Gene namesⁱ	Name:Batf3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1925491 Batf3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Selective loss of CD8-alpha⁺ classical dendritic cells (cDCs) and CD103⁺ dendritic cells, without abnormalities in other hematopoietic cell types or architecture. Dendritic cells are defective in cross-presentation, and mice lack virus-specific CD8⁺ T-cell responses to West Nile virus. Mice also show reduced priming of CD8 T-cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. Mice are extremely susceptible to T.gondii infection, with decreased production of interleukin-12 (IL12) and interferon-gamma. In contrast, mice are more resistant to L.monocytogenes infection.5 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000326107	1 – 118	Basic leucine zipper transcriptional factor ATF-like 3Add BLAST		118

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	PhosphoserineBy similarity		1
Modified residueⁱ	24	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9D275
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9D275
PaxDbⁱ	Q9D275
PRIDEⁱ	Q9D275

PTM databases

PhosphoSitePlusⁱ	Q9D275

PhosphoSitePlusⁱ

Q9D275

Expressionⁱ

Tissue specificityⁱ

Highly expressed in CD8-alpha⁺ classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000026630 Expressed in 134 organ(s), highest expression level in primary oocyte
Genevisibleⁱ	Q9D275 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

Protein-protein interaction databases

BioGridⁱ	237877, 13 interactors
IntActⁱ	Q9D275, 11 interactors
STRINGⁱ	10090.ENSMUSP00000027943

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D275
SMRⁱ	Q9D275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 91	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	30 – 55	Basic motifPROSITE-ProRule annotationAdd BLAST		26
Regionⁱ	56 – 84	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016869
HOGENOMⁱ	HOG000236325
HOVERGENⁱ	HBG096186
InParanoidⁱ	Q9D275
KEGG Orthology (KO) More...KOⁱ	K09034
OMAⁱ	LTDEMKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YSM
PhylomeDBⁱ	Q9D275
TreeFamⁱ	TF332340

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029818 p21SNFT
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF13 PTHR23351:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9D275-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQGPPAVSV LQRSVDAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT 
        60         70         80         90        100
QKADKLHEEH ESLEQENSVL RREISKLKEE LRHLSEVLKE HEKMCPLLLC 
       110 
PMNFVQLRSD PVASCLPR

Length:118

Mass (Da):13,657

Last modified:June 1, 2001 - v1

Checksum:ⁱ67EA973561ECCFA1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK020278 mRNA Translation: BAB32053.1 BC117083 mRNA Translation: AAI17084.1 BC117085 mRNA Translation: AAI17086.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15615.1
NCBI Reference Sequences More...RefSeqⁱ	NP_084336.1, NM_030060.2
UniGeneⁱ	Mm.6922

Genome annotation databases

Ensemblⁱ	ENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630
GeneIDⁱ	381319
KEGGⁱ	mmu:381319
UCSC genome browser More...UCSCⁱ	uc007ecd.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9D275	basic leucine zipper transcriptional factor ATF-like 3 isoform X1		MESAU		128	UniRef90_Q9D275
UPI00038C5FD1		MICOH		123
UPI000B4E9693		MERUN		118
UPI00042AC1CA		PERMB		117

Protein	Similar proteins		Species	Score	Length	Source
Q9D275	Basic leucine zipper transcriptional factor ATF-like 3		HUMAN		127	UniRef50_Q9NR55
Basic leucine zipper transcriptional factor ATF-like 3		RAT		133
Basic leucine zipper ATF-like transcription factor 3		CHLSB		129
Uncharacterized protein		COLAP		127
Uncharacterized protein		MACNE		127
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK020278 mRNA Translation: BAB32053.1 BC117083 mRNA Translation: AAI17084.1 BC117085 mRNA Translation: AAI17086.1
CCDSⁱ	CCDS15615.1
RefSeqⁱ	NP_084336.1, NM_030060.2
UniGeneⁱ	Mm.6922

3D structure databases

ProteinModelPortalⁱ	Q9D275
SMRⁱ	Q9D275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	237877, 13 interactors
IntActⁱ	Q9D275, 11 interactors
STRINGⁱ	10090.ENSMUSP00000027943

PTM databases

PhosphoSitePlusⁱ	Q9D275

PhosphoSitePlusⁱ

Q9D275

Proteomic databases

EPDⁱ	Q9D275
MaxQBⁱ	Q9D275
PaxDbⁱ	Q9D275
PRIDEⁱ	Q9D275

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027943; ENSMUSP00000027943; ENSMUSG00000026630
GeneIDⁱ	381319
KEGGⁱ	mmu:381319
UCSCⁱ	uc007ecd.1 mouse

Organism-specific databases

CTDⁱ	55509
MGIⁱ	MGI:1925491 Batf3

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00390000016869
HOGENOMⁱ	HOG000236325
HOVERGENⁱ	HBG096186
InParanoidⁱ	Q9D275
KOⁱ	K09034
OMAⁱ	LTDEMKH
OrthoDBⁱ	EOG091G0YSM
PhylomeDBⁱ	Q9D275
TreeFamⁱ	TF332340

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9D275
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026630 Expressed in 134 organ(s), highest expression level in primary oocyte
Genevisibleⁱ	Q9D275 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029818 p21SNFT
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF13 PTHR23351:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BATF3_MOUSE
Accessionⁱ	Q9D275Primary (citable) accession number: Q9D275
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9D275 (BATF3_MOUSE)

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Basic leucine zipper transcriptional factor ATF-like 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ