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Entry version 156 (12 Aug 2020)
Sequence version 3 (02 May 2006)
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Protein

Serine protease HTRA3

Gene

Htra3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei197Charge relay systemBy similarity1
Active sitei233Charge relay systemBy similarity1
Active sitei311Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.284

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease HTRA3 (EC:3.4.21.-)
Alternative name(s):
High-temperature requirement factor A3
Pregnancy-related serine protease
Toll-associated serine protease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Htra3
Synonyms:Prsp, Tasp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925808, Htra3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi311S → A: Abolishes protease activity. No inhibition of BMP4-mediated signaling. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002695024 – 459Serine protease HTRA3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 107PROSITE-ProRule annotation
Disulfide bondi96 ↔ 132PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9D236

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D236

PeptideAtlas

More...
PeptideAtlasi
Q9D236

PRoteomics IDEntifications database

More...
PRIDEi
Q9D236

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D236

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest level of isoform 1 in maternal part of the placenta, moderate level in heart, testis and ovary, low level in muscle and lung. High expression found in granulosa cells of the ovary. Expressed in bone matrix, particularly in articular chondrocytes. Very low level of isoform 2 expressed in placenta. Expressed in the bone matrix, particularly in articular chondrocytes.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First expressed at 9.5 dpc. Levels then increase until 14.5 dpc after which they remain high until newborn. First detected in the eye at 10.5 dpc and then expressed in tissues associated with skeletal tissue. At 12.5 dpc expressed in the vertebral rudiments in the tail region and, in the developing eye, in lens epithelium. At adulthood, expression found in the ganglion cell layer and the inner nuclear layer of the retina. In the developing heart at 16.5 dpc, expressed in the endocardial cushion. In the trachea at this stage, in outer layers and in the aorta, in adventitia.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during early pregnancy coinciding with placentation. Also up-regulated in joint cartilage affected by arthritis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029096, Expressed in decidua and 224 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D236, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (By similarity).

Interacts with MYH9 (By similarity).

Interacts with TGFB1; the interaction inhibits TGFB-mediated signaling.

Interacts with BMP4; the interaction inhibits BMP4-mediated signaling.

Interacts with TGFB2 and GDF5.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084910

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9D236, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9D236

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 83IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST57
Domaini76 – 134Kazal-likePROSITE-ProRule annotationAdd BLAST59
Domaini365 – 450PDZPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 347Serine proteaseAdd BLAST167

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT3F, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020120_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D236

KEGG Orthology (KO)

More...
KOi
K08785

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAKGVCQ

Database of Orthologous Groups

More...
OrthoDBi
630723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D236

TreeFam database of animal gene trees

More...
TreeFami
TF323480

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR000867, IGFBP-like
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR009003, Peptidase_S1_PA
IPR001940, Peptidase_S1C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00219, IGFBP, 1 hit
PF07648, Kazal_2, 1 hit
PF17820, PDZ_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00834, PROTEASES2C

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00121, IB, 1 hit
SM00280, KAZAL, 1 hit
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF50156, SSF50156, 1 hit
SSF50494, SSF50494, 1 hit
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51323, IGFBP_N_2, 1 hit
PS51465, KAZAL_2, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D236-3) [UniParc]FASTAAdd to basket
Also known as: A, Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQARALLPAT LAILATLAVL ALAREPPAAP CPARCDVSRC PSPRCPGGYV
60 70 80 90 100
PDLCNCCLVC AASEGEPCGR PLDSPCGDSL ECVRGVCRCR WTHTVCGTDG
110 120 130 140 150
HTYADVCALQ AASRRALQVS GTPVRQLQKG ACPSGLHQLT SPRYKFNFIA
160 170 180 190 200
DVVEKIAPAV VHIELFLRHP LFGRNVPLSS GSGFIMSEAG LIVTNAHVVS
210 220 230 240 250
SSSTASGRQQ LKVQLQNGDA YEATIQDIDK KSDIATIVIH PKKKLPVLLL
260 270 280 290 300
GHSADLRPGE FVVAIGSPFA LQNTVTTGIV STAQRDGKEL GLRDSDMDYI
310 320 330 340 350
QTDAIINYGN SGGPLVNLDG EVIGINTLKV AAGISFAIPS DRITRFLSEF
360 370 380 390 400
QNKHVKDWKK RFIGIRMRTI TPSLVEELKA ANPDFPAVSS GIYVQEVVPN
410 420 430 440 450
SPSQRGGIQD GDIIVKVNGR PLADSSELQE AVLNESSLLL EVRRGNDDLL

FSIIPEVVM
Length:459
Mass (Da):49,149
Last modified:May 2, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE13C6042DC4AFF64
GO
Isoform 2 (identifier: Q9D236-4) [UniParc]FASTAAdd to basket
Also known as: B, Short

The sequence of this isoform differs from the canonical sequence as follows:
     357-363: DWKKRFI → ALSPALH
     364-459: Missing.

Show »
Length:363
Mass (Da):38,510
Checksum:iF8454CF274FE007B
GO
Isoform 3 (identifier: Q9D236-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-278: GSPFALQNTVTTG → ESPLCPAEHRDKC

Show »
Length:459
Mass (Da):49,342
Checksum:i3886D70109328C82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YV92A0A0J9YV92_MOUSE
Serine protease HTRA3
Htra3
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVC4A0A0J9YVC4_MOUSE
Serine protease HTRA3
Htra3
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YU80A0A0J9YU80_MOUSE
Serine protease HTRA3
Htra3
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti286D → T in AAK70226 (Ref. 2) Curated1
Sequence conflicti440L → AA in AAK70226 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018127266 – 278GSPFA…TVTTG → ESPLCPAEHRDKC in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_018128357 – 363DWKKRFI → ALSPALH in isoform 2. 1 Publication7
Alternative sequenceiVSP_018129364 – 459Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY156509 mRNA Translation: AAO17289.1
AY280664 mRNA Translation: AAQ16583.1
AY037300 mRNA Translation: AAK70226.1
BC138587 mRNA Translation: AAI38588.1
BC138588 mRNA Translation: AAI38589.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19233.1 [Q9D236-3]
CCDS39071.1 [Q9D236-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001036080.1, NM_001042615.2 [Q9D236-4]
NP_084403.2, NM_030127.3 [Q9D236-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000087629; ENSMUSP00000084910; ENSMUSG00000029096 [Q9D236-3]
ENSMUST00000114233; ENSMUSP00000109871; ENSMUSG00000029096 [Q9D236-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
78558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:78558

UCSC genome browser

More...
UCSCi
uc008xea.2, mouse [Q9D236-3]
uc008xeb.2, mouse [Q9D236-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY156509 mRNA Translation: AAO17289.1
AY280664 mRNA Translation: AAQ16583.1
AY037300 mRNA Translation: AAK70226.1
BC138587 mRNA Translation: AAI38588.1
BC138588 mRNA Translation: AAI38589.1
CCDSiCCDS19233.1 [Q9D236-3]
CCDS39071.1 [Q9D236-4]
RefSeqiNP_001036080.1, NM_001042615.2 [Q9D236-4]
NP_084403.2, NM_030127.3 [Q9D236-3]

3D structure databases

SMRiQ9D236
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084910

Protein family/group databases

MEROPSiS01.284

PTM databases

iPTMnetiQ9D236
PhosphoSitePlusiQ9D236

Proteomic databases

MaxQBiQ9D236
PaxDbiQ9D236
PeptideAtlasiQ9D236
PRIDEiQ9D236

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9597, 108 antibodies

Genome annotation databases

EnsembliENSMUST00000087629; ENSMUSP00000084910; ENSMUSG00000029096 [Q9D236-3]
ENSMUST00000114233; ENSMUSP00000109871; ENSMUSG00000029096 [Q9D236-4]
GeneIDi78558
KEGGimmu:78558
UCSCiuc008xea.2, mouse [Q9D236-3]
uc008xeb.2, mouse [Q9D236-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94031
MGIiMGI:1925808, Htra3

Phylogenomic databases

eggNOGiENOG502QT3F, Eukaryota
GeneTreeiENSGT00940000159570
HOGENOMiCLU_020120_6_2_1
InParanoidiQ9D236
KOiK08785
OMAiFAKGVCQ
OrthoDBi630723at2759
PhylomeDBiQ9D236
TreeFamiTF323480

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
78558, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Htra3, mouse

Protein Ontology

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PROi
PR:Q9D236
RNActiQ9D236, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029096, Expressed in decidua and 224 other tissues
GenevisibleiQ9D236, MM

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR000867, IGFBP-like
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR009003, Peptidase_S1_PA
IPR001940, Peptidase_S1C
PfamiView protein in Pfam
PF00219, IGFBP, 1 hit
PF07648, Kazal_2, 1 hit
PF17820, PDZ_6, 1 hit
PRINTSiPR00834, PROTEASES2C
SMARTiView protein in SMART
SM00121, IB, 1 hit
SM00280, KAZAL, 1 hit
SM00228, PDZ, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF50156, SSF50156, 1 hit
SSF50494, SSF50494, 1 hit
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323, IGFBP_N_2, 1 hit
PS51465, KAZAL_2, 1 hit
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTRA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D236
Secondary accession number(s): B2RRV0, Q6WLC5, Q6YDR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 2, 2006
Last modified: August 12, 2020
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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