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Protein

B-cell CLL/lymphoma 9 protein

Gene

Bcl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway (By similarity).By similarity1 Publication

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • transcription coactivator activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 9 protein
Short name:
B-cell lymphoma 9 protein
Short name:
Bcl-9
Gene namesi
Name:Bcl9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924828 Bcl9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648861 – 1425B-cell CLL/lymphoma 9 proteinAdd BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei172PhosphothreonineBy similarity1
Modified residuei315PhosphothreonineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei800Asymmetric dimethylarginineCombined sources1
Modified residuei843N6-acetyllysineCombined sources1
Modified residuei906PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D219
PaxDbiQ9D219
PeptideAtlasiQ9D219
PRIDEiQ9D219

PTM databases

iPTMnetiQ9D219
PhosphoSitePlusiQ9D219

Expressioni

Gene expression databases

BgeeiENSMUSG00000038256 Expressed in 235 organ(s), highest expression level in neocortex
CleanExiMM_BCL9
GenevisibleiQ9D219 MM

Interactioni

Subunit structurei

Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218773, 1 interactor
IntActiQ9D219, 2 interactors
STRINGi10090.ENSMUSP00000046152

Structurei

3D structure databases

ProteinModelPortaliQ9D219
SMRiQ9D219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni177 – 205Interaction with PYGO1By similarityAdd BLAST29
Regioni358 – 374Interaction with CTNNB1By similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 1377Pro-richAdd BLAST1147
Compositional biasi1379 – 1424Met-richAdd BLAST46

Sequence similaritiesi

Belongs to the BCL9 family.Curated

Phylogenomic databases

eggNOGiENOG410IICK Eukaryota
ENOG410XRMX LUCA
GeneTreeiENSGT00730000110915
HOGENOMiHOG000060118
HOVERGENiHBG031116
InParanoidiQ9D219
KOiK22649
OMAiPGHNPMR
OrthoDBiEOG091G00PV
PhylomeDBiQ9D219
TreeFamiTF331144

Family and domain databases

InterProiView protein in InterPro
IPR015668 Bcl-9/Bcl-9l
IPR024670 BCL9_beta-catenin-bd_dom
PANTHERiPTHR15185 PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502 BCL9, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG
60 70 80 90 100
KPGGSASQSQ PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE
110 120 130 140 150
RSISADSFDQ RDPGTPNDDS DIKECNSADH IKSQESQHTP HSMTPSTATA
160 170 180 190 200
PRSSTPSHGQ TPAPEPISAQ KTPAKVVYVF STEMANKAAE AVLKGQVETI
210 220 230 240 250
VSFHIQNISN SKSERSTAPL NTQIPTLRND PKPLPQQPPA PANQDQNSSQ
260 270 280 290 300
NARLQPTPPI QAPAPKPTAA PRPLDRESPG VENKLIPPVG SPGSSTPLPP
310 320 330 340 350
DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSGGE PPTLGENPDG
360 370 380 390 400
LSQEQLEHRE RSLQTLRDIQ RMLFPDEKEF TAGQTGGPQQ NTGVLDGPQK
410 420 430 440 450
KPDGPIQAMM SQSQSLGKGP GPRTDVGAPF GPQGHRDVPF SPDEMVPPNM
460 470 480 490 500
SSQSGPIGPD HLDHMTPEQI AWLKLQQEFY EEKRRKQEQV VVQQCSLQDM
510 520 530 540 550
MVHQHGPRGV VRGPPPPYQM APGEGWAPGA EPFPDGINIS HSLPPRGMAP
560 570 580 590 600
HPNMPGSQMR LPGFAGMINS EMEGPNVPNP ASRPGLSGVS WPDDVPKIPD
610 620 630 640 650
GRNFPPGQGV FSGPGRGERF PNPQGLSEEM FQQQLAEKQL ALPPGMSMEG
660 670 680 690 700
IRPGMEMNRM IPGSQRHMEP GSNPIFPRIP VEGPLSPSRG DFPKGMPPQI
710 720 730 740 750
GPGRELEFGM VPGGMKGEVN LNVNMGSSSQ MIPQKMREAG AGPEEMMKLR
760 770 780 790 800
PGSSEMLPAQ QKMVPLPFGE HPQQEYGVGP RPFLPMSQGP GSNSGLRNLR
810 820 830 840 850
EPIGPDQRTN SRLSHMPPLP LNPSSNPTSL STAPPVQRGL GRKPLDISVA
860 870 880 890 900
GSQVHSPGIN PLKSPTMHQV QSPMLGSPSG NLKSPQTPSQ LAGMLAGPAA
910 920 930 940 950
AASIKSPPVL GSAAASPVHL KSPSLPAPSP GWTSSPKPPL QSPGIPPNHK
960 970 980 990 1000
APLTMASPAM LGSVESGGPP PPTASQPASV NIPGSLPSST PYPMPPEPTL
1010 1020 1030 1040 1050
SQNPLSIMMS RMSKFAMPSS TPLYHDAIKT VASSDDDSPP ARSPNLPSMN
1060 1070 1080 1090 1100
SMPGMGINTQ NPRISGPNPV VPMPTLSPMG MTQPLSHSNQ MPSPNAMGPS
1110 1120 1130 1140 1150
IPPHGVPMGP GLMSHNPIMG HGSQEPPMVP QGRMGFPQGF PPVQSPPQQV
1160 1170 1180 1190 1200
PFPHNGPTGG QGNFPGGIGF PGEGPLGRPS NLPQSSADPA LCKPGGPGAP
1210 1220 1230 1240 1250
DSFTVLGNSM PSVFTDPDLQ EVIRPGATGI PEFDLSRIIP SEKPSQTLQY
1260 1270 1280 1290 1300
FPRGEVPGRK QPQGPGPGFS HMQGMMSDQA PRMGLALPGM GGPGPVGTPD
1310 1320 1330 1340 1350
IPLGTSPSMP GHNPMRPPAF LQQGMMGPHH RMMSPAQSTV PGPATLMTNP
1360 1370 1380 1390 1400
AAAVGMIPGK DRGPAGLYTH PGPVGSPGMM MSMQGMMGPQ QNIMIPPQMR
1410 1420
PRGMAADVGM GGFSQGPGNP GNMMF
Length:1,425
Mass (Da):148,971
Last modified:September 27, 2005 - v3
Checksum:i77347CF56FC4A815
GO

Sequence cautioni

The sequence AAH19641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1134M → V in BAB32190 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296061 mRNA Translation: AAQ62699.1
BC019641 mRNA Translation: AAH19641.1 Different initiation.
BC137850 mRNA Translation: AAI37851.1
AK020724 mRNA Translation: BAB32190.1
AK084676 mRNA Translation: BAC39248.1
CCDSiCCDS17654.1
RefSeqiNP_084209.3, NM_029933.4
XP_006502351.1, XM_006502288.3
XP_006502352.1, XM_006502289.3
XP_006502353.1, XM_006502290.2
UniGeneiMm.226175
Mm.429113
Mm.482931

Genome annotation databases

EnsembliENSMUST00000046521; ENSMUSP00000046152; ENSMUSG00000038256
ENSMUST00000166341; ENSMUSP00000131692; ENSMUSG00000038256
GeneIDi77578
KEGGimmu:77578
UCSCiuc008qot.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296061 mRNA Translation: AAQ62699.1
BC019641 mRNA Translation: AAH19641.1 Different initiation.
BC137850 mRNA Translation: AAI37851.1
AK020724 mRNA Translation: BAB32190.1
AK084676 mRNA Translation: BAC39248.1
CCDSiCCDS17654.1
RefSeqiNP_084209.3, NM_029933.4
XP_006502351.1, XM_006502288.3
XP_006502352.1, XM_006502289.3
XP_006502353.1, XM_006502290.2
UniGeneiMm.226175
Mm.429113
Mm.482931

3D structure databases

ProteinModelPortaliQ9D219
SMRiQ9D219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218773, 1 interactor
IntActiQ9D219, 2 interactors
STRINGi10090.ENSMUSP00000046152

PTM databases

iPTMnetiQ9D219
PhosphoSitePlusiQ9D219

Proteomic databases

MaxQBiQ9D219
PaxDbiQ9D219
PeptideAtlasiQ9D219
PRIDEiQ9D219

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046521; ENSMUSP00000046152; ENSMUSG00000038256
ENSMUST00000166341; ENSMUSP00000131692; ENSMUSG00000038256
GeneIDi77578
KEGGimmu:77578
UCSCiuc008qot.2 mouse

Organism-specific databases

CTDi607
MGIiMGI:1924828 Bcl9

Phylogenomic databases

eggNOGiENOG410IICK Eukaryota
ENOG410XRMX LUCA
GeneTreeiENSGT00730000110915
HOGENOMiHOG000060118
HOVERGENiHBG031116
InParanoidiQ9D219
KOiK22649
OMAiPGHNPMR
OrthoDBiEOG091G00PV
PhylomeDBiQ9D219
TreeFamiTF331144

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

PROiPR:Q9D219
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038256 Expressed in 235 organ(s), highest expression level in neocortex
CleanExiMM_BCL9
GenevisibleiQ9D219 MM

Family and domain databases

InterProiView protein in InterPro
IPR015668 Bcl-9/Bcl-9l
IPR024670 BCL9_beta-catenin-bd_dom
PANTHERiPTHR15185 PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502 BCL9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBCL9_MOUSE
AccessioniPrimary (citable) accession number: Q9D219
Secondary accession number(s): B2RQC0
, Q67FX9, Q8BUJ8, Q8VE74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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