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Protein

Eukaryotic translation elongation factor 1 epsilon-1

Gene

Eef1e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive modulator of ATM response to DNA damage.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • glutathione metabolic process Source: GO_Central
  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of cellular senescence Source: MGI
  • positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • translation Source: UniProtKB-KW

Keywordsi

Biological processProtein biosynthesis

Protein family/group databases

MoonProtiQ9D1M4

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation elongation factor 1 epsilon-1
Alternative name(s):
Elongation factor p18
Multisynthase complex auxiliary component p181 Publication
Gene namesi
Name:Eef1e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913393 Eef1e1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002211332 – 174Eukaryotic translation elongation factor 1 epsilon-1Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1M4
MaxQBiQ9D1M4
PaxDbiQ9D1M4
PeptideAtlasiQ9D1M4
PRIDEiQ9D1M4

PTM databases

iPTMnetiQ9D1M4
PhosphoSitePlusiQ9D1M4

Expressioni

Inductioni

By DNA damaging agents, such as UV, adriamycin, actinomycin D and cisplatin.1 Publication

Gene expression databases

BgeeiENSMUSG00000001707
GenevisibleiQ9D1M4 MM

Interactioni

Subunit structurei

Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:12060739). Can interact simultaneously with MARS and EPRS. Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ9D1M4, 1 interactor
MINTiQ9D1M4
STRINGi10090.ENSMUSP00000001757

Structurei

3D structure databases

ProteinModelPortaliQ9D1M4
SMRiQ9D1M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 173GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 56N-terminalBy similarityAdd BLAST55
Regioni57 – 63LinkerBy similarity7
Regioni64 – 152C-terminalBy similarityAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 169By similarityAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00390000003564
HOGENOMiHOG000026786
HOVERGENiHBG003019
InParanoidiQ9D1M4
KOiK15439
OMAiDGHSSKD
OrthoDBiEOG091G0VQB
PhylomeDBiQ9D1M4
TreeFamiTF326005

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAELRLL EKSLGLKPGN KYSAQGERQI PVLQTNNGPS LMGLSTIATH
60 70 80 90 100
LVKQASKEHL LGSTAEEKAM VQQWLEFRVT RVDGHSSKED TQTLLKDLNS
110 120 130 140 150
YLEDKVYLAG HNITLADILL YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ
160 170
HYPDIRQHLS SIVFIKNRLY ANSH
Length:174
Mass (Da):19,859
Last modified:June 1, 2001 - v1
Checksum:iAC804776D9C0590E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003335 mRNA Translation: BAB22723.1
BC048466 mRNA Translation: AAH48466.1
CCDSiCCDS26465.1
RefSeqiNP_079656.1, NM_025380.2
UniGeneiMm.490319

Genome annotation databases

EnsembliENSMUST00000001757; ENSMUSP00000001757; ENSMUSG00000001707
GeneIDi66143
KEGGimmu:66143
UCSCiuc007qdw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMCA3_MOUSE
AccessioniPrimary (citable) accession number: Q9D1M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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