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Protein

Protein SEC13 homolog

Gene

Sec13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (PubMed:27354378).By similarity1 Publication
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI
  • structural molecule activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SEC13 homologCurated
Alternative name(s):
GATOR complex protein SEC13Curated
SEC13-like protein 1
SEC13-related protein
Gene namesi
Name:Sec13
Synonyms:Sec13l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99832 Sec13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Lysosome, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000512042 – 322Protein SEC13 homologAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei184PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D1M0
MaxQBiQ9D1M0
PaxDbiQ9D1M0
PeptideAtlasiQ9D1M0
PRIDEiQ9D1M0

2D gel databases

REPRODUCTION-2DPAGEiQ9D1M0

PTM databases

iPTMnetiQ9D1M0
PhosphoSitePlusiQ9D1M0
SwissPalmiQ9D1M0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030298 Expressed in 299 organ(s), highest expression level in secondary oocyte
CleanExiMM_SEC13
GenevisibleiQ9D1M0 MM

Interactioni

Subunit structurei

At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. Interacts with SEC16A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225548, 2 interactors
IntActiQ9D1M0, 6 interactors
MINTiQ9D1M0
STRINGi10090.ENSMUSP00000032440

Structurei

3D structure databases

ProteinModelPortaliQ9D1M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 50WD 1Add BLAST40
Repeati55 – 96WD 2Add BLAST42
Repeati101 – 144WD 3Add BLAST44
Repeati148 – 204WD 4Add BLAST57
Repeati210 – 253WD 5Add BLAST44
Repeati260 – 299WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1332 Eukaryota
ENOG410XPFM LUCA
GeneTreeiENSGT00550000075049
HOGENOMiHOG000216895
HOVERGENiHBG057343
InParanoidiQ9D1M0
KOiK14004
OMAiGQWACIS
OrthoDBiEOG091G0DTE
PhylomeDBiQ9D1M0
TreeFamiTF300815

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037596 Sec13
IPR037363 Sec13/Seh1_fam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11024 PTHR11024, 1 hit
PTHR11024:SF2 PTHR11024:SF2, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D1M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVMNTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI
60 70 80 90 100
ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHS
110 120 130 140 150
GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT
160 170 180 190 200
IGCNAVSWAP AVVPGSLIDQ PSGQKPNYIK KFASGGCDNL IKLWREEEDG
210 220 230 240 250
QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASG
260 270 280 290 300
NMWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI
310 320
SDVNKGQGSV SASITEGQQN EQ
Length:322
Mass (Da):35,566
Last modified:January 23, 2007 - v3
Checksum:i255AF0ACC4C5D891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41D → H in BAB26480 (PubMed:16141072).Curated1
Sequence conflicti298V → G in AAH02128 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003354 mRNA Translation: BAB22732.1
AK009755 mRNA Translation: BAB26480.1
BC002128 mRNA Translation: AAH02128.1
CCDSiCCDS39596.1
RefSeqiNP_077168.2, NM_024206.4
UniGeneiMm.29296
Mm.465981

Genome annotation databases

EnsembliENSMUST00000032440; ENSMUSP00000032440; ENSMUSG00000030298
GeneIDi110379
KEGGimmu:110379
UCSCiuc009dhm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003354 mRNA Translation: BAB22732.1
AK009755 mRNA Translation: BAB26480.1
BC002128 mRNA Translation: AAH02128.1
CCDSiCCDS39596.1
RefSeqiNP_077168.2, NM_024206.4
UniGeneiMm.29296
Mm.465981

3D structure databases

ProteinModelPortaliQ9D1M0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225548, 2 interactors
IntActiQ9D1M0, 6 interactors
MINTiQ9D1M0
STRINGi10090.ENSMUSP00000032440

PTM databases

iPTMnetiQ9D1M0
PhosphoSitePlusiQ9D1M0
SwissPalmiQ9D1M0

2D gel databases

REPRODUCTION-2DPAGEiQ9D1M0

Proteomic databases

EPDiQ9D1M0
MaxQBiQ9D1M0
PaxDbiQ9D1M0
PeptideAtlasiQ9D1M0
PRIDEiQ9D1M0

Protocols and materials databases

DNASUi110379
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032440; ENSMUSP00000032440; ENSMUSG00000030298
GeneIDi110379
KEGGimmu:110379
UCSCiuc009dhm.1 mouse

Organism-specific databases

CTDi6396
MGIiMGI:99832 Sec13

Phylogenomic databases

eggNOGiKOG1332 Eukaryota
ENOG410XPFM LUCA
GeneTreeiENSGT00550000075049
HOGENOMiHOG000216895
HOVERGENiHBG057343
InParanoidiQ9D1M0
KOiK14004
OMAiGQWACIS
OrthoDBiEOG091G0DTE
PhylomeDBiQ9D1M0
TreeFamiTF300815

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

PROiPR:Q9D1M0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030298 Expressed in 299 organ(s), highest expression level in secondary oocyte
CleanExiMM_SEC13
GenevisibleiQ9D1M0 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037596 Sec13
IPR037363 Sec13/Seh1_fam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11024 PTHR11024, 1 hit
PTHR11024:SF2 PTHR11024:SF2, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC13_MOUSE
AccessioniPrimary (citable) accession number: Q9D1M0
Secondary accession number(s): Q99M12, Q9D712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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