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Protein

Ragulator complex protein LAMTOR5

Gene

Lamtor5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR5
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Gene namesi
Name:Lamtor5
Synonyms:Hbxip, Xip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915826 Lamtor5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000660081 – 91Ragulator complex protein LAMTOR5Add BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1L9
MaxQBiQ9D1L9
PaxDbiQ9D1L9
PeptideAtlasiQ9D1L9
PRIDEiQ9D1L9

PTM databases

iPTMnetiQ9D1L9
PhosphoSitePlusiQ9D1L9

Expressioni

Gene expression databases

BgeeiENSMUSG00000087260 Expressed in 22 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_HBXIP
ExpressionAtlasiQ9D1L9 baseline and differential
GenevisibleiQ9D1L9 MM

Interactioni

Subunit structurei

Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.By similarity

Protein-protein interaction databases

IntActiQ9D1L9, 3 interactors
MINTiQ9D1L9
STRINGi10090.ENSMUSP00000129012

Structurei

3D structure databases

ProteinModelPortaliQ9D1L9
SMRiQ9D1L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR5 family.Curated

Phylogenomic databases

eggNOGiENOG410IZVH Eukaryota
ENOG4111WFD LUCA
GeneTreeiENSGT00390000006247
HOVERGENiHBG010343
InParanoidiQ9D1L9
KOiK16344
PhylomeDBiQ9D1L9

Family and domain databases

InterProiView protein in InterPro
IPR024135 LAMTOR5
PANTHERiPTHR13342 PTHR13342, 1 hit
PfamiView protein in Pfam
PF16672 LAMTOR5, 1 hit
PRINTSiPR02092 HEPBVIRUSXIP

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D1L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ
60 70 80 90
QAARLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Length:91
Mass (Da):9,642
Last modified:June 1, 2001 - v1
Checksum:i2CD9E762ABD07BE4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UW70G3UW70_MOUSE
MCG21719
Lamtor5 Hbxip, mCG_21719
145Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003358 mRNA Translation: BAB22734.1
AK146289 mRNA Translation: BAE27046.1
BC028547 mRNA Translation: AAH28547.1
RefSeqiNP_081050.2, NM_026774.2
UniGeneiMm.290035

Genome annotation databases

EnsembliENSMUST00000199317; ENSMUSP00000143494; ENSMUSG00000087260
GeneIDi68576
KEGGimmu:68576

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003358 mRNA Translation: BAB22734.1
AK146289 mRNA Translation: BAE27046.1
BC028547 mRNA Translation: AAH28547.1
RefSeqiNP_081050.2, NM_026774.2
UniGeneiMm.290035

3D structure databases

ProteinModelPortaliQ9D1L9
SMRiQ9D1L9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D1L9, 3 interactors
MINTiQ9D1L9
STRINGi10090.ENSMUSP00000129012

PTM databases

iPTMnetiQ9D1L9
PhosphoSitePlusiQ9D1L9

Proteomic databases

EPDiQ9D1L9
MaxQBiQ9D1L9
PaxDbiQ9D1L9
PeptideAtlasiQ9D1L9
PRIDEiQ9D1L9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000199317; ENSMUSP00000143494; ENSMUSG00000087260
GeneIDi68576
KEGGimmu:68576

Organism-specific databases

CTDi10542
MGIiMGI:1915826 Lamtor5

Phylogenomic databases

eggNOGiENOG410IZVH Eukaryota
ENOG4111WFD LUCA
GeneTreeiENSGT00390000006247
HOVERGENiHBG010343
InParanoidiQ9D1L9
KOiK16344
PhylomeDBiQ9D1L9

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

PROiPR:Q9D1L9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000087260 Expressed in 22 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_HBXIP
ExpressionAtlasiQ9D1L9 baseline and differential
GenevisibleiQ9D1L9 MM

Family and domain databases

InterProiView protein in InterPro
IPR024135 LAMTOR5
PANTHERiPTHR13342 PTHR13342, 1 hit
PfamiView protein in Pfam
PF16672 LAMTOR5, 1 hit
PRINTSiPR02092 HEPBVIRUSXIP
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR5_MOUSE
AccessioniPrimary (citable) accession number: Q9D1L9
Secondary accession number(s): Q3UJV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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