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Protein

Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

Gene

Chchd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
Gene namesi
Name:Chchd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1261428 Chchd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291611 – 153Coiled-coil-helix-coiled-coil-helix domain-containing protein 2Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi116 ↔ 146PROSITE-ProRule annotation
Disulfide bondi126 ↔ 136PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9D1L0
MaxQBiQ9D1L0
PaxDbiQ9D1L0
PeptideAtlasiQ9D1L0
PRIDEiQ9D1L0

PTM databases

iPTMnetiQ9D1L0
PhosphoSitePlusiQ9D1L0

Expressioni

Gene expression databases

BgeeiENSMUSG00000070493 Expressed in 25 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ9D1L0 MM

Interactioni

Subunit structurei

Interacts with RBPJ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199534, 1 interactor
IntActiQ9D1L0, 1 interactor
STRINGi10090.ENSMUSP00000091835

Structurei

3D structure databases

ProteinModelPortaliQ9D1L0
SMRiQ9D1L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 153CHCHPROSITE-ProRule annotationAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi116 – 126Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi136 – 146Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Phylogenomic databases

eggNOGiKOG4090 Eukaryota
ENOG41126E7 LUCA
GeneTreeiENSGT00440000038159
HOGENOMiHOG000194088
HOVERGENiHBG059852
InParanoidiQ9D1L0
KOiK22758
OMAiCDADARN
OrthoDBiEOG091G114W
PhylomeDBiQ9D1L0
TreeFamiTF318060

Family and domain databases

PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D1L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGSRSRTS RVTPPASRAP QMRAAPRRAP AAQPPAAAAP SAVGSPAAAP
60 70 80 90 100
RQPGLMAQMA TTAAGVAVGS AVGHTLGHAI TGGFSGGGSA EPAKPDITYQ
110 120 130 140 150
EPQGAQLQNQ QSFGPCSLEI KQFLECAQNQ SDVKLCEGFN EVLRQCRIAN

GLM
Length:153
Mass (Da):15,661
Last modified:June 1, 2001 - v1
Checksum:i86D001C54F3354B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003399 mRNA Translation: BAB22764.1
AK088374 mRNA Translation: BAC40313.1
AK145492 mRNA Translation: BAE26469.1
AK160779 mRNA Translation: BAE36003.1
AK162133 mRNA Translation: BAE36745.1
AK166796 mRNA Translation: BAE39024.1
AK167593 mRNA Translation: BAE39651.1
BC042717 mRNA Translation: AAH42717.1
BC082287 mRNA Translation: AAH82287.1
BC084682 mRNA Translation: AAH84682.1
CCDSiCCDS19702.1
RefSeqiNP_077128.2, NM_024166.6
UniGeneiMm.299062
Mm.30133

Genome annotation databases

EnsembliENSMUST00000094280; ENSMUSP00000091835; ENSMUSG00000070493
GeneIDi14004
KEGGimmu:14004
UCSCiuc008ztn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003399 mRNA Translation: BAB22764.1
AK088374 mRNA Translation: BAC40313.1
AK145492 mRNA Translation: BAE26469.1
AK160779 mRNA Translation: BAE36003.1
AK162133 mRNA Translation: BAE36745.1
AK166796 mRNA Translation: BAE39024.1
AK167593 mRNA Translation: BAE39651.1
BC042717 mRNA Translation: AAH42717.1
BC082287 mRNA Translation: AAH82287.1
BC084682 mRNA Translation: AAH84682.1
CCDSiCCDS19702.1
RefSeqiNP_077128.2, NM_024166.6
UniGeneiMm.299062
Mm.30133

3D structure databases

ProteinModelPortaliQ9D1L0
SMRiQ9D1L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199534, 1 interactor
IntActiQ9D1L0, 1 interactor
STRINGi10090.ENSMUSP00000091835

PTM databases

iPTMnetiQ9D1L0
PhosphoSitePlusiQ9D1L0

Proteomic databases

EPDiQ9D1L0
MaxQBiQ9D1L0
PaxDbiQ9D1L0
PeptideAtlasiQ9D1L0
PRIDEiQ9D1L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094280; ENSMUSP00000091835; ENSMUSG00000070493
GeneIDi14004
KEGGimmu:14004
UCSCiuc008ztn.1 mouse

Organism-specific databases

CTDi51142
MGIiMGI:1261428 Chchd2

Phylogenomic databases

eggNOGiKOG4090 Eukaryota
ENOG41126E7 LUCA
GeneTreeiENSGT00440000038159
HOGENOMiHOG000194088
HOVERGENiHBG059852
InParanoidiQ9D1L0
KOiK22758
OMAiCDADARN
OrthoDBiEOG091G114W
PhylomeDBiQ9D1L0
TreeFamiTF318060

Miscellaneous databases

ChiTaRSiChchd2 mouse
PROiPR:Q9D1L0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070493 Expressed in 25 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ9D1L0 MM

Family and domain databases

PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHCH2_MOUSE
AccessioniPrimary (citable) accession number: Q9D1L0
Secondary accession number(s): Q3TUG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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