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Protein

V-type proton ATPase subunit F

Gene

Atp6v1f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:Atp6v1f
Synonyms:Atp6s14, Vatf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913394 Atp6v1f

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448001 – 119V-type proton ATPase subunit FAdd BLAST119

Proteomic databases

EPDiQ9D1K2
MaxQBiQ9D1K2
PaxDbiQ9D1K2
PeptideAtlasiQ9D1K2
PRIDEiQ9D1K2
TopDownProteomicsiQ9D1K2

2D gel databases

REPRODUCTION-2DPAGEiQ9D1K2

PTM databases

iPTMnetiQ9D1K2
PhosphoSitePlusiQ9D1K2

Expressioni

Gene expression databases

BgeeiENSMUSG00000004285 Expressed in 279 organ(s), highest expression level in pineal body
CleanExiMM_ATP6V1F
ExpressionAtlasiQ9D1K2 baseline and differential
GenevisibleiQ9D1K2 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi211247, 1 interactor
IntActiQ9D1K2, 4 interactors
MINTiQ9D1K2
STRINGi10090.ENSMUSP00000004396

Structurei

3D structure databases

ProteinModelPortaliQ9D1K2
SMRiQ9D1K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

eggNOGiKOG3432 Eukaryota
COG1436 LUCA
GeneTreeiENSGT00390000013208
HOGENOMiHOG000056545
HOVERGENiHBG004488
InParanoidiQ9D1K2
KOiK02151
OMAiQNVAEMI
OrthoDBiEOG091G0ZUA
PhylomeDBiQ9D1K2
TreeFamiTF300080

Family and domain databases

Gene3Di3.40.50.10580, 1 hit
InterProiView protein in InterPro
IPR008218 ATPase_V1-cplx_f_g_su
IPR005772 ATPase_V1-cplx_fsu_euk
IPR036906 ATPase_V1_fsu_sf
PfamiView protein in Pfam
PF01990 ATP-synt_F, 1 hit
PIRSFiPIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMiSSF159468 SSF159468, 1 hit
TIGRFAMsiTIGR01101 V_ATP_synt_F, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D1K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQRSIPAVLE IPSKEHPYDA
110
AKDSILRRAK GMFTAEDLR
Length:119
Mass (Da):13,370
Last modified:May 10, 2004 - v2
Checksum:i9FFA95BD2667AA2A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7B2B4F7B2B4_MOUSE
V-type proton ATPase subunit F
Atp6v1f
100Annotation score:
A0A0N4SVE1A0A0N4SVE1_MOUSE
V-type proton ATPase subunit F
Atp6v1f
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35N → D in BAB22780 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003419 mRNA Translation: BAB22780.1
AK007327 mRNA Translation: BAB24962.1
AK152153 mRNA Translation: BAE30988.1
AK152929 mRNA Translation: BAE31604.1
AK152959 mRNA Translation: BAE31622.1
BC016553 mRNA Translation: AAH16553.1
CCDSiCCDS19960.1
RefSeqiNP_079657.1, NM_025381.2
UniGeneiMm.371614

Genome annotation databases

EnsembliENSMUST00000004396; ENSMUSP00000004396; ENSMUSG00000004285
GeneIDi66144
KEGGimmu:66144
UCSCiuc009bdp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003419 mRNA Translation: BAB22780.1
AK007327 mRNA Translation: BAB24962.1
AK152153 mRNA Translation: BAE30988.1
AK152929 mRNA Translation: BAE31604.1
AK152959 mRNA Translation: BAE31622.1
BC016553 mRNA Translation: AAH16553.1
CCDSiCCDS19960.1
RefSeqiNP_079657.1, NM_025381.2
UniGeneiMm.371614

3D structure databases

ProteinModelPortaliQ9D1K2
SMRiQ9D1K2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211247, 1 interactor
IntActiQ9D1K2, 4 interactors
MINTiQ9D1K2
STRINGi10090.ENSMUSP00000004396

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ9D1K2
PhosphoSitePlusiQ9D1K2

2D gel databases

REPRODUCTION-2DPAGEiQ9D1K2

Proteomic databases

EPDiQ9D1K2
MaxQBiQ9D1K2
PaxDbiQ9D1K2
PeptideAtlasiQ9D1K2
PRIDEiQ9D1K2
TopDownProteomicsiQ9D1K2

Protocols and materials databases

DNASUi66144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004396; ENSMUSP00000004396; ENSMUSG00000004285
GeneIDi66144
KEGGimmu:66144
UCSCiuc009bdp.1 mouse

Organism-specific databases

CTDi9296
MGIiMGI:1913394 Atp6v1f

Phylogenomic databases

eggNOGiKOG3432 Eukaryota
COG1436 LUCA
GeneTreeiENSGT00390000013208
HOGENOMiHOG000056545
HOVERGENiHBG004488
InParanoidiQ9D1K2
KOiK02151
OMAiQNVAEMI
OrthoDBiEOG091G0ZUA
PhylomeDBiQ9D1K2
TreeFamiTF300080

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiAtp6v1f mouse
PROiPR:Q9D1K2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004285 Expressed in 279 organ(s), highest expression level in pineal body
CleanExiMM_ATP6V1F
ExpressionAtlasiQ9D1K2 baseline and differential
GenevisibleiQ9D1K2 MM

Family and domain databases

Gene3Di3.40.50.10580, 1 hit
InterProiView protein in InterPro
IPR008218 ATPase_V1-cplx_f_g_su
IPR005772 ATPase_V1-cplx_fsu_euk
IPR036906 ATPase_V1_fsu_sf
PfamiView protein in Pfam
PF01990 ATP-synt_F, 1 hit
PIRSFiPIRSF015945 ATPase_V1_F_euk, 1 hit
SUPFAMiSSF159468 SSF159468, 1 hit
TIGRFAMsiTIGR01101 V_ATP_synt_F, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATF_MOUSE
AccessioniPrimary (citable) accession number: Q9D1K2
Secondary accession number(s): Q3U6X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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