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Protein

SAP domain-containing ribonucleoprotein

Gene

Sarnp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processmRNA transport, Transcription, Transcription regulation, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
SAP domain-containing ribonucleoprotein
Alternative name(s):
Nuclear protein Hcc-1
Gene namesi
Name:Sarnp
Synonyms:Hcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 10, Chromosome 19

Organism-specific databases

MGIiMGI:1913368 Sarnp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000839192 – 210SAP domain-containing ribonucleoproteinAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei142N6-acetyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D1J3
MaxQBiQ9D1J3
PaxDbiQ9D1J3
PRIDEiQ9D1J3

PTM databases

iPTMnetiQ9D1J3
PhosphoSitePlusiQ9D1J3
SwissPalmiQ9D1J3

Expressioni

Gene expression databases

BgeeiENSMUSG00000051255 Expressed in 19 organ(s), highest expression level in embryonic stem cell
CleanExiMM_1110005A23RIK
ExpressionAtlasiQ9D1J3 baseline and differential
GenevisibleiQ9D1J3 MM

Interactioni

Subunit structurei

Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211227, 1 interactor
IntActiQ9D1J3, 1 interactor
MINTiQ9D1J3
STRINGi10090.ENSMUSP00000137244

Structurei

3D structure databases

ProteinModelPortaliQ9D1J3
SMRiQ9D1J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 42SAPPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

eggNOGiKOG4259 Eukaryota
ENOG4111IA4 LUCA
GeneTreeiENSGT00390000002944
HOGENOMiHOG000013054
InParanoidiQ9D1J3
KOiK18732
OMAiRFGCVVP
OrthoDBiEOG091G1BB1
PhylomeDBiQ9D1J3
TreeFamiTF319843

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D1J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAETVELHK LKLAELKQEC LARGLETKGI KQDLINRLQA YLEDHAEEEA
60 70 80 90 100
NEEDVLGDET EEEEPKPIEL PVKEEEPPEK AVDMASEKKV VKITSGIPQT
110 120 130 140 150
ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD TKPMVNLDKL
160 170 180 190 200
KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK
210
RKRAERFGIA
Length:210
Mass (Da):23,533
Last modified:January 23, 2007 - v3
Checksum:i15705691F989E9AB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6N2A0A1W2P6N2_MOUSE
SAP domain-containing ribonucleopro...
Sarnp
147Annotation score:
A0A1W2P7G2A0A1W2P7G2_MOUSE
SAP domain-containing ribonucleopro...
Sarnp
127Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003453 mRNA Translation: BAB22799.1
AK018773 mRNA Translation: BAB31400.1
AK088266 mRNA Translation: BAC40246.1
AK146248 mRNA Translation: BAE27010.1
BC027510 mRNA Translation: AAH27510.1
CCDSiCCDS36092.1
RefSeqiNP_079640.1, NM_025364.2
UniGeneiMm.235562
Mm.351579
Mm.372367

Genome annotation databases

EnsembliENSMUST00000056396; ENSMUSP00000137244; ENSMUSG00000051255
ENSMUST00000105230; ENSMUSP00000100863; ENSMUSG00000078427
GeneIDi66118
KEGGimmu:66118
UCSCiuc007hor.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003453 mRNA Translation: BAB22799.1
AK018773 mRNA Translation: BAB31400.1
AK088266 mRNA Translation: BAC40246.1
AK146248 mRNA Translation: BAE27010.1
BC027510 mRNA Translation: AAH27510.1
CCDSiCCDS36092.1
RefSeqiNP_079640.1, NM_025364.2
UniGeneiMm.235562
Mm.351579
Mm.372367

3D structure databases

ProteinModelPortaliQ9D1J3
SMRiQ9D1J3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211227, 1 interactor
IntActiQ9D1J3, 1 interactor
MINTiQ9D1J3
STRINGi10090.ENSMUSP00000137244

PTM databases

iPTMnetiQ9D1J3
PhosphoSitePlusiQ9D1J3
SwissPalmiQ9D1J3

Proteomic databases

EPDiQ9D1J3
MaxQBiQ9D1J3
PaxDbiQ9D1J3
PRIDEiQ9D1J3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056396; ENSMUSP00000137244; ENSMUSG00000051255
ENSMUST00000105230; ENSMUSP00000100863; ENSMUSG00000078427
GeneIDi66118
KEGGimmu:66118
UCSCiuc007hor.2 mouse

Organism-specific databases

CTDi84324
MGIiMGI:1913368 Sarnp

Phylogenomic databases

eggNOGiKOG4259 Eukaryota
ENOG4111IA4 LUCA
GeneTreeiENSGT00390000002944
HOGENOMiHOG000013054
InParanoidiQ9D1J3
KOiK18732
OMAiRFGCVVP
OrthoDBiEOG091G1BB1
PhylomeDBiQ9D1J3
TreeFamiTF319843

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing

Miscellaneous databases

PROiPR:Q9D1J3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051255 Expressed in 19 organ(s), highest expression level in embryonic stem cell
CleanExiMM_1110005A23RIK
ExpressionAtlasiQ9D1J3 baseline and differential
GenevisibleiQ9D1J3 MM

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSARNP_MOUSE
AccessioniPrimary (citable) accession number: Q9D1J3
Secondary accession number(s): Q3UJZ4, Q9CU18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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