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Protein

Methylmalonyl-CoA epimerase, mitochondrial

Gene

Mcee

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Cobalt; via tele nitrogenBy similarity1
Metal bindingi124Cobalt; via tele nitrogenBy similarity1
Metal bindingi174CobaltBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandCobalt, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71032 Propionyl-CoA catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonyl-CoA epimerase, mitochondrial (EC:5.1.99.1)
Alternative name(s):
DL-methylmalonyl-CoA racemase
Gene namesi
Name:Mcee
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920974 Mcee

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000001228439 – 178Methylmalonyl-CoA epimerase, mitochondrialAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-succinyllysineCombined sources1
Modified residuei152N6-acetyllysine; alternateCombined sources1
Modified residuei152N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D1I5
MaxQBiQ9D1I5
PaxDbiQ9D1I5
PeptideAtlasiQ9D1I5
PRIDEiQ9D1I5

PTM databases

iPTMnetiQ9D1I5
PhosphoSitePlusiQ9D1I5

Expressioni

Gene expression databases

BgeeiENSMUSG00000033429 Expressed in 277 organ(s), highest expression level in brown adipose tissue
CleanExiMM_MCEE
ExpressionAtlasiQ9D1I5 baseline and differential
GenevisibleiQ9D1I5 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D1I5, 1 interactor
MINTiQ9D1I5
STRINGi10090.ENSMUSP00000047855

Structurei

3D structure databases

ProteinModelPortaliQ9D1I5
SMRiQ9D1I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 178VOCPROSITE-ProRule annotationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 143Poly-Lys4

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2944 Eukaryota
COG0346 LUCA
GeneTreeiENSGT00390000004772
HOGENOMiHOG000232024
HOVERGENiHBG052426
InParanoidiQ9D1I5
KOiK05606
OMAiCYEVDDI
OrthoDBiEOG091G0WSQ
PhylomeDBiQ9D1I5
TreeFamiTF313417

Family and domain databases

CDDicd07249 MMCE, 1 hit
Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR017515 MeMalonyl-CoA_epimerase
IPR037523 VOC
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR03081 metmalonyl_epim, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D1I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRVVKAAAL AAGATGLFSR VQTSVAIGRS FSTPQSQFQE SSPVWKLGRL
60 70 80 90 100
NHVAVAVPDL EKASSFYRDV LGAQVSEVVP LPEHGVSVVF VNLGNTKMEL
110 120 130 140 150
LHPLGSDSPI TGFLQKNKAG GMHHVCIEVD NISAAVMDLK KKKIRSLSDE
160 170
AKIGAHGKPV IFLHPKDCGG VLVELEQA
Length:178
Mass (Da):19,017
Last modified:June 1, 2001 - v1
Checksum:i0A496AF10455D379
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQ27A0A0U1RQ27_MOUSE
Methylmalonyl CoA epimerase, isofor...
Mcee mCG_11820
124Annotation score:
A0A0U1RNJ6A0A0U1RNJ6_MOUSE
Methylmalonyl-CoA epimerase, mitoch...
Mcee
32Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003511 mRNA Translation: BAB22828.1
BC038157 mRNA Translation: AAH38157.1
CCDSiCCDS21334.1
RefSeqiNP_082902.1, NM_028626.1
UniGeneiMm.10093

Genome annotation databases

EnsembliENSMUST00000037205; ENSMUSP00000047855; ENSMUSG00000033429
GeneIDi73724
KEGGimmu:73724
UCSCiuc009hgi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003511 mRNA Translation: BAB22828.1
BC038157 mRNA Translation: AAH38157.1
CCDSiCCDS21334.1
RefSeqiNP_082902.1, NM_028626.1
UniGeneiMm.10093

3D structure databases

ProteinModelPortaliQ9D1I5
SMRiQ9D1I5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D1I5, 1 interactor
MINTiQ9D1I5
STRINGi10090.ENSMUSP00000047855

PTM databases

iPTMnetiQ9D1I5
PhosphoSitePlusiQ9D1I5

Proteomic databases

EPDiQ9D1I5
MaxQBiQ9D1I5
PaxDbiQ9D1I5
PeptideAtlasiQ9D1I5
PRIDEiQ9D1I5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037205; ENSMUSP00000047855; ENSMUSG00000033429
GeneIDi73724
KEGGimmu:73724
UCSCiuc009hgi.1 mouse

Organism-specific databases

CTDi84693
MGIiMGI:1920974 Mcee

Phylogenomic databases

eggNOGiKOG2944 Eukaryota
COG0346 LUCA
GeneTreeiENSGT00390000004772
HOGENOMiHOG000232024
HOVERGENiHBG052426
InParanoidiQ9D1I5
KOiK05606
OMAiCYEVDDI
OrthoDBiEOG091G0WSQ
PhylomeDBiQ9D1I5
TreeFamiTF313417

Enzyme and pathway databases

ReactomeiR-MMU-71032 Propionyl-CoA catabolism

Miscellaneous databases

ChiTaRSiMcee mouse
PROiPR:Q9D1I5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033429 Expressed in 277 organ(s), highest expression level in brown adipose tissue
CleanExiMM_MCEE
ExpressionAtlasiQ9D1I5 baseline and differential
GenevisibleiQ9D1I5 MM

Family and domain databases

CDDicd07249 MMCE, 1 hit
Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR017515 MeMalonyl-CoA_epimerase
IPR037523 VOC
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR03081 metmalonyl_epim, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCEE_MOUSE
AccessioniPrimary (citable) accession number: Q9D1I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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