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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Gene

Ndufaf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Alternative name(s):
Hormone-regulated proliferation-associated protein of 20 kDa homolog
Gene namesi
Name:Ndufaf4
Synonyms:Hrpap20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915743 Ndufaf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209892 – 173NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei35PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9D1H6
MaxQBiQ9D1H6
PaxDbiQ9D1H6
PeptideAtlasiQ9D1H6
PRIDEiQ9D1H6

PTM databases

iPTMnetiQ9D1H6
PhosphoSitePlusiQ9D1H6

Expressioni

Gene expression databases

BgeeiENSMUSG00000028261 Expressed in 291 organ(s), highest expression level in primary oocyte
CleanExiMM_1110007M04RIK
ExpressionAtlasiQ9D1H6 baseline and differential
GenevisibleiQ9D1H6 MM

Interactioni

Subunit structurei

Binds calmodulin. Interacts with NDUFAF3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029925

Structurei

3D structure databases

ProteinModelPortaliQ9D1H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDUFAF4 family.Curated

Phylogenomic databases

eggNOGiKOG4481 Eukaryota
ENOG4111W8K LUCA
GeneTreeiENSGT00390000001627
HOGENOMiHOG000231584
InParanoidiQ9D1H6
KOiK18161
OMAiKFINDHQ
OrthoDBiEOG091G0YY3
PhylomeDBiQ9D1H6
TreeFamiTF323532

Family and domain databases

InterProiView protein in InterPro
IPR009622 NDUFAF4
PANTHERiPTHR13338 PTHR13338, 1 hit
PfamiView protein in Pfam
PF06784 UPF0240, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD339506 UPF0240, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D1H6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGARVTRALR NFNVEKRAER EISKRKPSMA PKHPSTRDLL QEHRSQYPEI
60 70 80 90 100
EEVVSKKDNK LLSLLRDVYV DSKDPVPALP VKVEPRQEPK EFRLPIGNHF
110 120 130 140 150
DKNITDIPKG KITVVEALTL LNNHKLSPET WTAEKIAQEY YLELKDVNSL
160 170
LKYFVTFEVK ILPPEDRKAI QSK
Length:173
Mass (Da):20,082
Last modified:June 1, 2001 - v1
Checksum:i80EEED8C3E3CBF6B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJX3A2AJX3_MOUSE
NADH dehydrogenase [ubiquinone] 1 a...
Ndufaf4
127Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003553 mRNA Translation: BAB22852.1
AK034728 mRNA Translation: BAC28809.1
AK160341 mRNA Translation: BAE35747.1
BC028764 mRNA Translation: AAH28764.1
CCDSiCCDS18007.1
RefSeqiNP_081018.1, NM_026742.4
UniGeneiMm.204831

Genome annotation databases

EnsembliENSMUST00000029925; ENSMUSP00000029925; ENSMUSG00000028261
GeneIDi68493
KEGGimmu:68493
UCSCiuc008sed.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003553 mRNA Translation: BAB22852.1
AK034728 mRNA Translation: BAC28809.1
AK160341 mRNA Translation: BAE35747.1
BC028764 mRNA Translation: AAH28764.1
CCDSiCCDS18007.1
RefSeqiNP_081018.1, NM_026742.4
UniGeneiMm.204831

3D structure databases

ProteinModelPortaliQ9D1H6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029925

PTM databases

iPTMnetiQ9D1H6
PhosphoSitePlusiQ9D1H6

Proteomic databases

EPDiQ9D1H6
MaxQBiQ9D1H6
PaxDbiQ9D1H6
PeptideAtlasiQ9D1H6
PRIDEiQ9D1H6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029925; ENSMUSP00000029925; ENSMUSG00000028261
GeneIDi68493
KEGGimmu:68493
UCSCiuc008sed.2 mouse

Organism-specific databases

CTDi29078
MGIiMGI:1915743 Ndufaf4

Phylogenomic databases

eggNOGiKOG4481 Eukaryota
ENOG4111W8K LUCA
GeneTreeiENSGT00390000001627
HOGENOMiHOG000231584
InParanoidiQ9D1H6
KOiK18161
OMAiKFINDHQ
OrthoDBiEOG091G0YY3
PhylomeDBiQ9D1H6
TreeFamiTF323532

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNdufaf4 mouse
PROiPR:Q9D1H6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028261 Expressed in 291 organ(s), highest expression level in primary oocyte
CleanExiMM_1110007M04RIK
ExpressionAtlasiQ9D1H6 baseline and differential
GenevisibleiQ9D1H6 MM

Family and domain databases

InterProiView protein in InterPro
IPR009622 NDUFAF4
PANTHERiPTHR13338 PTHR13338, 1 hit
PfamiView protein in Pfam
PF06784 UPF0240, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD339506 UPF0240, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF4_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H6
Secondary accession number(s): Q3TV72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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