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Protein
Submitted name:

MCG4778

Gene

Muc16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
MCG4778Imported
Submitted name:
Mucin 16Imported
Gene namesi
Name:Muc16Imported
ORF Names:mCG_4778Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920982 Muc16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei203 – 229HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000109564 Expressed in 63 organ(s), highest expression level in umbilical cord

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 189SEAInterPro annotationAdd BLAST121

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEHG Eukaryota
ENOG4111B0P LUCA
GeneTreeiENSGT00440000039287
HOGENOMiHOG000185212
OrthoDBiEOG091G00SO

Family and domain databases

Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR028850 MUC16
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR14672 PTHR14672, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 1 hit
SUPFAMiSSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D1H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSGSTVVTL EALFSSHLDP NLVKQVFLNK TLNASSHWLG ATYQLKDLHV
60 70 80 90 100
IDMKTSILLP AEIPTTSSSS QHFNLNFTIT NLPYSQDIAQ PSTTKYQQTK
110 120 130 140 150
RSIENALNQL FRNSSIKSYF SDCQVLAFRS VSNNNNHTGV DSLCNFSPLA
160 170 180 190 200
RRVDRVAIYE EFLRMTHNGT QLLNFTLDRK SVFVDGYSQN RDDDVMKNSG
210 220 230 240 250
LPFWAIILIC LAVLLVLITC LMCCFLVTVC RRKKEGDYQV QRHRLAYYLS

HLDLRKLQ
Length:258
Mass (Da):29,426
Last modified:June 1, 2001 - v1
Checksum:iB64D9B63394D84E7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJ72A0A140LJ72_MOUSE
Mucin 16
Muc16
8,478Annotation score:
A0A140LI05A0A140LI05_MOUSE
Mucin 16
Muc16
2,566Annotation score:
A0A140LIA5A0A140LIA5_MOUSE
Mucin 16
Muc16
366Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154519 Genomic DNA No translation available.
AC154784 Genomic DNA No translation available.
AC162941 Genomic DNA No translation available.
AK003577 mRNA Translation: BAB22869.1
CH466522 Genomic DNA Translation: EDL25052.1
UniGeneiMm.490076

Genome annotation databases

EnsembliENSMUST00000034653; ENSMUSP00000034653; ENSMUSG00000109564
UCSCiuc009ogv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154519 Genomic DNA No translation available.
AC154784 Genomic DNA No translation available.
AC162941 Genomic DNA No translation available.
AK003577 mRNA Translation: BAB22869.1
CH466522 Genomic DNA Translation: EDL25052.1
UniGeneiMm.490076

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVZNMR-A65-185[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034653; ENSMUSP00000034653; ENSMUSG00000109564
UCSCiuc009ogv.1 mouse

Organism-specific databases

MGIiMGI:1920982 Muc16

Phylogenomic databases

eggNOGiENOG410IEHG Eukaryota
ENOG4111B0P LUCA
GeneTreeiENSGT00440000039287
HOGENOMiHOG000185212
OrthoDBiEOG091G00SO

Enzyme and pathway databases

ReactomeiR-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000109564 Expressed in 63 organ(s), highest expression level in umbilical cord

Family and domain databases

Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR028850 MUC16
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR14672 PTHR14672, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 1 hit
SUPFAMiSSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9D1H1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1H1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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