UniProtKB - Q9D1G1 (RAB1B_MOUSE)
Ras-related protein Rab-1B
Rab1b
Functioni
Miscellaneous
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | GTPBy similarity | 9 | |
Nucleotide bindingi | 33 – 40 | GTPBy similarity | 8 | |
Nucleotide bindingi | 63 – 67 | GTPBy similarity | 5 | |
Nucleotide bindingi | 121 – 124 | GTPBy similarity | 4 | |
Nucleotide bindingi | 151 – 153 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB
GO - Biological processi
- autophagosome assembly Source: GO_Central
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: MGI
- intracellular protein transport Source: GO_Central
- positive regulation of glycoprotein metabolic process Source: MGI
- regulation of autophagosome assembly Source: MGI
- virion assembly Source: Ensembl
Keywordsi
Biological process | Autophagy, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-MMU-204005, COPII-mediated vesicle transport R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-1B |
Gene namesi | Name:Rab1b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923558, Rab1b |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
- Preautophagosomal structure membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
- perinuclear region By similarity
Note: Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity).By similarity
Golgi apparatus
- Golgi apparatus Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Other locations
- endomembrane system Source: GO_Central
- endoplasmic reticulum-Golgi intermediate compartment Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- phagophore assembly site membrane Source: MGI
- synapse Source: MGI
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | S → N: Increases the interaction with MTMR6. 1 Publication | 1 | |
Mutagenesisi | 67 | Q → L: No effect on the interaction with MTMR6. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121062 | 1 – 201 | Ras-related protein Rab-1BAdd BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 76 | O-(2-cholinephosphoryl)serineBy similarity | 1 | |
Lipidationi | 200 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 201 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 201 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | Q9D1G1 |
jPOSTi | Q9D1G1 |
MaxQBi | Q9D1G1 |
PaxDbi | Q9D1G1 |
PRIDEi | Q9D1G1 |
PTM databases
iPTMneti | Q9D1G1 |
PhosphoSitePlusi | Q9D1G1 |
SwissPalmi | Q9D1G1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024870, Expressed in lip and 289 other tissues |
ExpressionAtlasi | Q9D1G1, baseline and differential |
Genevisiblei | Q9D1G1, MM |
Interactioni
Subunit structurei
Interacts with MICAL1 and MICAL2.
Interacts (GTP-bound form) with MICALCL, MICAL1 and MILCAL3.
Interacts with GDI1; the interaction requires the GDP-bound state.
Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.
Interacts with RabGAP TBC1D20 (By similarity).
Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820).
Interacts (in GDP-bound form) with lipid phosphatase MTMR7 (PubMed:23188820).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 218071, 3 interactors |
IntActi | Q9D1G1, 17 interactors |
MINTi | Q9D1G1 |
STRINGi | 10090.ENSMUSP00000025804 |
Miscellaneous databases
RNActi | Q9D1G1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 83 | Switch 2 region; required for interaction with REP1/CHMBy similarityAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 37 – 45 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0084, Eukaryota |
GeneTreei | ENSGT00940000155078 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | Q9D1G1 |
OMAi | FMIMASE |
OrthoDBi | 1149105at2759 |
PhylomeDBi | Q9D1G1 |
TreeFami | TF300097 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI
60 70 80 90 100
ELDGKTIKLQ IWDTAGQERF RTITSSYYRG AHGIIVVYDV TDQESYANVK
110 120 130 140 150
QWLQEIDRYA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGVPFLET
160 170 180 190 200
SAKNATNVEQ AFMTMAAEIK KRMGPGAASG GERPNLKIDS TPVKPASGGC
C
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BA38 | A0A494BA38_MOUSE | Ras-related protein Rab-1B | Rab1b | 182 | Annotation score: | ||
A0A494B945 | A0A494B945_MOUSE | Ras-related protein Rab-1B | Rab1b | 254 | Annotation score: | ||
A0A494BBL7 | A0A494BBL7_MOUSE | Ras-related protein Rab-1B | Rab1b | 189 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003609 mRNA Translation: BAB22888.1 AK156726 mRNA Translation: BAE33821.1 BC016408 mRNA Translation: AAH16408.1 |
CCDSi | CCDS29452.1 |
RefSeqi | NP_083852.1, NM_029576.3 |
Genome annotation databases
Ensembli | ENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870 |
GeneIDi | 76308 |
KEGGi | mmu:76308 |
UCSCi | uc008gcf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003609 mRNA Translation: BAB22888.1 AK156726 mRNA Translation: BAE33821.1 BC016408 mRNA Translation: AAH16408.1 |
CCDSi | CCDS29452.1 |
RefSeqi | NP_083852.1, NM_029576.3 |
3D structure databases
SMRi | Q9D1G1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 218071, 3 interactors |
IntActi | Q9D1G1, 17 interactors |
MINTi | Q9D1G1 |
STRINGi | 10090.ENSMUSP00000025804 |
PTM databases
iPTMneti | Q9D1G1 |
PhosphoSitePlusi | Q9D1G1 |
SwissPalmi | Q9D1G1 |
Proteomic databases
EPDi | Q9D1G1 |
jPOSTi | Q9D1G1 |
MaxQBi | Q9D1G1 |
PaxDbi | Q9D1G1 |
PRIDEi | Q9D1G1 |
Protocols and materials databases
Antibodypediai | 4132, 279 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870 |
GeneIDi | 76308 |
KEGGi | mmu:76308 |
UCSCi | uc008gcf.1, mouse |
Organism-specific databases
CTDi | 81876 |
MGIi | MGI:1923558, Rab1b |
Phylogenomic databases
eggNOGi | KOG0084, Eukaryota |
GeneTreei | ENSGT00940000155078 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | Q9D1G1 |
OMAi | FMIMASE |
OrthoDBi | 1149105at2759 |
PhylomeDBi | Q9D1G1 |
TreeFami | TF300097 |
Enzyme and pathway databases
Reactomei | R-MMU-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-MMU-204005, COPII-mediated vesicle transport R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 76308, 3 hits in 17 CRISPR screens |
ChiTaRSi | Rab1b, mouse |
PROi | PR:Q9D1G1 |
RNActi | Q9D1G1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024870, Expressed in lip and 289 other tissues |
ExpressionAtlasi | Q9D1G1, baseline and differential |
Genevisiblei | Q9D1G1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB1B_MOUSE | |
Accessioni | Q9D1G1Primary (citable) accession number: Q9D1G1 Secondary accession number(s): Q3U0N1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families