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Protein

Ras-related protein Rab-1B

Gene

Rab1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.By similarity

Miscellaneous

Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.By similarity

Activity regulationi

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi33 – 40GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-1B
Gene namesi
Name:Rab1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1923558 Rab1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210621 – 201Ras-related protein Rab-1BAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei76O-(2-cholinephosphoryl)serineBy similarity1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Modified residuei201Cysteine methyl esterSequence analysis1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9D1G1
MaxQBiQ9D1G1
PaxDbiQ9D1G1
PRIDEiQ9D1G1

PTM databases

iPTMnetiQ9D1G1
PhosphoSitePlusiQ9D1G1
SwissPalmiQ9D1G1

Expressioni

Gene expression databases

BgeeiENSMUSG00000024870 Expressed in 272 organ(s), highest expression level in heart
CleanExiMM_RAB1B
ExpressionAtlasiQ9D1G1 baseline and differential
GenevisibleiQ9D1G1 MM

Interactioni

Subunit structurei

Interacts with MICAL1 and MICAL2. Interacts (GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.By similarity

Protein-protein interaction databases

BioGridi218071, 2 interactors
IntActiQ9D1G1, 17 interactors
MINTiQ9D1G1
STRINGi10090.ENSMUSP00000025804

Structurei

3D structure databases

ProteinModelPortaliQ9D1G1
SMRiQ9D1G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 83Switch 2 region; required for interaction with REP1/CHMBy similarityAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9D1G1
KOiK07875
OMAiIDRFACE
OrthoDBiEOG091G0LA6
PhylomeDBiQ9D1G1
TreeFamiTF300097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D1G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI
60 70 80 90 100
ELDGKTIKLQ IWDTAGQERF RTITSSYYRG AHGIIVVYDV TDQESYANVK
110 120 130 140 150
QWLQEIDRYA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGVPFLET
160 170 180 190 200
SAKNATNVEQ AFMTMAAEIK KRMGPGAASG GERPNLKIDS TPVKPASGGC

C
Length:201
Mass (Da):22,187
Last modified:June 1, 2001 - v1
Checksum:i870DFF52AEF4B2BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003609 mRNA Translation: BAB22888.1
AK156726 mRNA Translation: BAE33821.1
BC016408 mRNA Translation: AAH16408.1
CCDSiCCDS29452.1
RefSeqiNP_083852.1, NM_029576.3
UniGeneiMm.182563
Mm.297430

Genome annotation databases

EnsembliENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870
GeneIDi76308
KEGGimmu:76308
UCSCiuc008gcf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003609 mRNA Translation: BAB22888.1
AK156726 mRNA Translation: BAE33821.1
BC016408 mRNA Translation: AAH16408.1
CCDSiCCDS29452.1
RefSeqiNP_083852.1, NM_029576.3
UniGeneiMm.182563
Mm.297430

3D structure databases

ProteinModelPortaliQ9D1G1
SMRiQ9D1G1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218071, 2 interactors
IntActiQ9D1G1, 17 interactors
MINTiQ9D1G1
STRINGi10090.ENSMUSP00000025804

PTM databases

iPTMnetiQ9D1G1
PhosphoSitePlusiQ9D1G1
SwissPalmiQ9D1G1

Proteomic databases

EPDiQ9D1G1
MaxQBiQ9D1G1
PaxDbiQ9D1G1
PRIDEiQ9D1G1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870
GeneIDi76308
KEGGimmu:76308
UCSCiuc008gcf.1 mouse

Organism-specific databases

CTDi81876
MGIiMGI:1923558 Rab1b

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9D1G1
KOiK07875
OMAiIDRFACE
OrthoDBiEOG091G0LA6
PhylomeDBiQ9D1G1
TreeFamiTF300097

Enzyme and pathway databases

ReactomeiR-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRab1b mouse
PROiPR:Q9D1G1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024870 Expressed in 272 organ(s), highest expression level in heart
CleanExiMM_RAB1B
ExpressionAtlasiQ9D1G1 baseline and differential
GenevisibleiQ9D1G1 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB1B_MOUSE
AccessioniPrimary (citable) accession number: Q9D1G1
Secondary accession number(s): Q3U0N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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