Rab1b

Functionⁱ

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.By similarity

Miscellaneous

Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.By similarity

Activity regulationⁱ

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	15 – 23	GTPBy similarity	9
Nucleotide bindingⁱ	33 – 40	GTPBy similarity	8
Nucleotide bindingⁱ	63 – 67	GTPBy similarity	5
Nucleotide bindingⁱ	121 – 124	GTPBy similarity	4
Nucleotide bindingⁱ	151 – 153	GTPBy similarity	3

GO - Molecular functionⁱ

GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
ER to Golgi vesicle-mediated transport Source: MGI
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of glycoprotein metabolic process Source: MGI
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of autophagosome assembly Source: MGI
virion assembly Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-MMU-204005 COPII-mediated vesicle transport R-MMU-6807878 COPI-mediated anterograde transport R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-1B
Gene namesⁱ	Name:Rab1b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1923558 Rab1b

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121062	1 – 201	Ras-related protein Rab-1BAdd BLAST		201

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	76	O-(2-cholinephosphoryl)serineBy similarity	1
Lipidationⁱ	200	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	201	Cysteine methyl esterSequence analysis	1
Lipidationⁱ	201	S-geranylgeranyl cysteineBy similarity	1

Post-translational modificationⁱ

Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).By similarity

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	Q9D1G1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9D1G1
PaxDbⁱ	Q9D1G1
PRIDEⁱ	Q9D1G1

PTM databases

iPTMnetⁱ	Q9D1G1
PhosphoSitePlusⁱ	Q9D1G1
SwissPalmⁱ	Q9D1G1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024870 Expressed in 272 organ(s), highest expression level in heart
CleanExⁱ	MM_RAB1B
ExpressionAtlasⁱ	Q9D1G1 baseline and differential
Genevisibleⁱ	Q9D1G1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with MICAL1 and MICAL2. Interacts (GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.By similarity

Protein-protein interaction databases

BioGridⁱ	218071, 2 interactors
IntActⁱ	Q9D1G1, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q9D1G1
STRINGⁱ	10090.ENSMUSP00000025804

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D1G1
SMRⁱ	Q9D1G1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	64 – 83	Switch 2 region; required for interaction with REP1/CHMBy similarityAdd BLAST		20

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	37 – 45	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0084 Eukaryota ENOG410XQN5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q9D1G1
KEGG Orthology (KO) More...KOⁱ	K07875
OMAⁱ	IDRFACE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LA6
PhylomeDBⁱ	Q9D1G1
TreeFamⁱ	TF300097

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9D1G1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI 
        60         70         80         90        100
ELDGKTIKLQ IWDTAGQERF RTITSSYYRG AHGIIVVYDV TDQESYANVK 
       110        120        130        140        150
QWLQEIDRYA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGVPFLET 
       160        170        180        190        200
SAKNATNVEQ AFMTMAAEIK KRMGPGAASG GERPNLKIDS TPVKPASGGC 

C

Length:201

Mass (Da):22,187

Last modified:June 1, 2001 - v1

Checksum:ⁱ870DFF52AEF4B2BE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003609 mRNA Translation: BAB22888.1 AK156726 mRNA Translation: BAE33821.1 BC016408 mRNA Translation: AAH16408.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29452.1
NCBI Reference Sequences More...RefSeqⁱ	NP_083852.1, NM_029576.3
UniGeneⁱ	Mm.182563 Mm.297430

Genome annotation databases

Ensemblⁱ	ENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870
GeneIDⁱ	76308
KEGGⁱ	mmu:76308
UCSC genome browser More...UCSCⁱ	uc008gcf.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9D1G1	RAB1B, member RAS oncogene family, isoform CRA_c		MOUSE		201	UniRef100_Q9D1G1
Ras-related protein Rab-1B		CRIGR		201
Uncharacterized protein		NEOLE		201

Protein	Similar proteins		Species	Score	Length	Source
Q9D1G1	Ras-related protein Rab-1B		RAT		201	UniRef90_P10536
Ras-related protein Rab-1B		MACFA		201
Ras-related protein Rab-1B		PIG		201
Putative Ras-related protein Rab-1C		HUMAN		201
ras-related protein Rab-1B isoform X1		LIPVE		223
+53

Protein	Similar proteins		Species	Score	Length	Source
Q9D1G1	GTP-binding protein YPT1	)	YEAST		206	UniRef50_P01123
Ras-related protein Rab-1A		PIG		205
Ras-related protein RABD2c		ARATH		202
GTP-binding protein YPTM2		MAIZE		203
Ras-related protein ORAB-1		DIPOM		202
+1042

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003609 mRNA Translation: BAB22888.1 AK156726 mRNA Translation: BAE33821.1 BC016408 mRNA Translation: AAH16408.1
CCDSⁱ	CCDS29452.1
RefSeqⁱ	NP_083852.1, NM_029576.3
UniGeneⁱ	Mm.182563 Mm.297430

3D structure databases

ProteinModelPortalⁱ	Q9D1G1
SMRⁱ	Q9D1G1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	218071, 2 interactors
IntActⁱ	Q9D1G1, 17 interactors
MINTⁱ	Q9D1G1
STRINGⁱ	10090.ENSMUSP00000025804

PTM databases

iPTMnetⁱ	Q9D1G1
PhosphoSitePlusⁱ	Q9D1G1
SwissPalmⁱ	Q9D1G1

Proteomic databases

EPDⁱ	Q9D1G1
MaxQBⁱ	Q9D1G1
PaxDbⁱ	Q9D1G1
PRIDEⁱ	Q9D1G1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025804; ENSMUSP00000025804; ENSMUSG00000024870
GeneIDⁱ	76308
KEGGⁱ	mmu:76308
UCSCⁱ	uc008gcf.1 mouse

Organism-specific databases

CTDⁱ	81876
MGIⁱ	MGI:1923558 Rab1b

Phylogenomic databases

eggNOGⁱ	KOG0084 Eukaryota ENOG410XQN5 LUCA
GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q9D1G1
KOⁱ	K07875
OMAⁱ	IDRFACE
OrthoDBⁱ	EOG091G0LA6
PhylomeDBⁱ	Q9D1G1
TreeFamⁱ	TF300097

Enzyme and pathway databases

Reactomeⁱ	R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-MMU-204005 COPII-mediated vesicle transport R-MMU-6807878 COPI-mediated anterograde transport R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	Rab1b mouse
Protein Ontology More...PROⁱ	PR:Q9D1G1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024870 Expressed in 272 organ(s), highest expression level in heart
CleanExⁱ	MM_RAB1B
ExpressionAtlasⁱ	Q9D1G1 baseline and differential
Genevisibleⁱ	Q9D1G1 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB1B_MOUSE
Accessionⁱ	Q9D1G1Primary (citable) accession number: Q9D1G1 Secondary accession number(s): Q3U0N1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9D1G1 (RAB1B_MOUSE)

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Ras-related protein Rab-1B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Golgi apparatus

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ