UniProtKB - Q9D1E8 (PLCE_MOUSE)
Protein
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
Gene
Agpat5
Organism
Mus musculus (Mouse)
Status
Functioni
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (By similarity). Activity toward lysophosphatidylglycerol not detectable (By similarity).By similarity1 Publication
Caution
It is uncertain whether Met-1 or Met-12 is the initiator.Curated
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA1 PublicationEC:2.3.1.511 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2), Glycerol-3-phosphate acyltransferase 4 (Gpat4), Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam)
- Lysocardiolipin acyltransferase 1 (Lclat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (Agpat5), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (Agpat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
- Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), CDP-diacylglycerol synthase (Tamm41), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), CDP-diacylglycerol synthase (Tamm41), Phosphatidate cytidylyltransferase 1 (Cds1), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 2 (Cds2), CDP-diacylglycerol synthase (Tamm41), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase (Cds2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: MGI
- transferase activity, transferring acyl groups Source: GO_Central
GO - Biological processi
- acylglycerol metabolic process Source: MGI
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
- hematopoietic progenitor cell differentiation Source: MGI
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-1483166, Synthesis of PA |
UniPathwayi | UPA00557;UER00613 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC:2.3.1.511 Publication)Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase 5 Short name: 1-AGP acyltransferase 5 Short name: 1-AGPAT 5 Lysophosphatidic acid acyltransferase epsilon Short name: LPAAT-epsilon |
Gene namesi | Name:Agpat5 Synonyms:D8Ertd319e |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1196345, Agpat5 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Nucleus
- Nucleus envelope By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nuclear envelope Source: UniProtKB
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 35 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208201 | 1 – 365 | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilonAdd BLAST | 365 |
Proteomic databases
EPDi | Q9D1E8 |
MaxQBi | Q9D1E8 |
PaxDbi | Q9D1E8 |
PRIDEi | Q9D1E8 |
PTM databases
iPTMneti | Q9D1E8 |
PhosphoSitePlusi | Q9D1E8 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031467, Expressed in zone of skin and 321 other tissues |
ExpressionAtlasi | Q9D1E8, baseline and differential |
Genevisiblei | Q9D1E8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 206392, 3 interactors |
IntActi | Q9D1E8, 2 interactors |
STRINGi | 10090.ENSMUSP00000117025 |
Miscellaneous databases
RNActi | Q9D1E8, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 93 – 98 | HXXXXD motifBy similarity | 6 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1505, Eukaryota |
GeneTreei | ENSGT00950000182836 |
InParanoidi | Q9D1E8 |
OMAi | DWIIADM |
OrthoDBi | 959325at2759 |
PhylomeDBi | Q9D1E8 |
TreeFami | TF314346 |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9D1E8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLSLVLHTY SMRYLLPSVL LLGSAPTYLL AWTLWRVLSA LMPARLYQRV
60 70 80 90 100
DDRLYCVYQN MVLFFFENYT GVQILLYGDL PKNKENVIYL ANHQSTVDWI
110 120 130 140 150
VADMLAARQD ALGHVRYVLK DKLKWLPLYG FYFAQHGGIY VKRSAKFNDK
160 170 180 190 200
EMRSKLQSYV NAGTPMYLVI FPEGTRYNAT YTKLLSASQA FAAQRGLAVL
210 220 230 240 250
KHVLTPRIKA THVAFDSMKS HLDAIYDVTV VYEGNEKGSG KYSNPPSMTE
260 270 280 290 300
FLCKQCPKLH IHFDRIDRNE VPEEQEHMKK WLHERFEIKD RLLIEFYDSP
310 320 330 340 350
DPERRNKFPG KSVHSRLSVK KTLPSVLILG SLTAVMLMTE SGRKLYMGTW
360
LYGTLLGCLW FVIKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WGD9 | F8WGD9_MOUSE | 1-acyl-sn-glycerol-3-phosphate acyl... | Agpat5 | 291 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | L → W in AAN75571 (Ref. 1) Curated | 1 | |
Sequence conflicti | 128 | L → M in AAN75571 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY161042 mRNA Translation: AAN75571.1 AK003649 mRNA Translation: BAB22915.2 AK082137 mRNA Translation: BAC38421.1 AK089885 mRNA Translation: BAC40983.1 AK152709 mRNA Translation: BAE31436.1 AK152889 mRNA Translation: BAE31572.1 AK155378 mRNA Translation: BAE33229.1 BC031987 mRNA Translation: AAH31987.2 |
CCDSi | CCDS22126.1 |
RefSeqi | NP_081068.1, NM_026792.3 |
Genome annotation databases
Ensembli | ENSMUST00000149565; ENSMUSP00000117025; ENSMUSG00000031467 |
GeneIDi | 52123 |
KEGGi | mmu:52123 |
UCSCi | uc009kzv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY161042 mRNA Translation: AAN75571.1 AK003649 mRNA Translation: BAB22915.2 AK082137 mRNA Translation: BAC38421.1 AK089885 mRNA Translation: BAC40983.1 AK152709 mRNA Translation: BAE31436.1 AK152889 mRNA Translation: BAE31572.1 AK155378 mRNA Translation: BAE33229.1 BC031987 mRNA Translation: AAH31987.2 |
CCDSi | CCDS22126.1 |
RefSeqi | NP_081068.1, NM_026792.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 206392, 3 interactors |
IntActi | Q9D1E8, 2 interactors |
STRINGi | 10090.ENSMUSP00000117025 |
PTM databases
iPTMneti | Q9D1E8 |
PhosphoSitePlusi | Q9D1E8 |
Proteomic databases
EPDi | Q9D1E8 |
MaxQBi | Q9D1E8 |
PaxDbi | Q9D1E8 |
PRIDEi | Q9D1E8 |
Protocols and materials databases
Antibodypediai | 2138, 292 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000149565; ENSMUSP00000117025; ENSMUSG00000031467 |
GeneIDi | 52123 |
KEGGi | mmu:52123 |
UCSCi | uc009kzv.1, mouse |
Organism-specific databases
CTDi | 55326 |
MGIi | MGI:1196345, Agpat5 |
Phylogenomic databases
eggNOGi | KOG1505, Eukaryota |
GeneTreei | ENSGT00950000182836 |
InParanoidi | Q9D1E8 |
OMAi | DWIIADM |
OrthoDBi | 959325at2759 |
PhylomeDBi | Q9D1E8 |
TreeFami | TF314346 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00613 |
Reactomei | R-MMU-1483166, Synthesis of PA |
Miscellaneous databases
BioGRID-ORCSi | 52123, 0 hits in 17 CRISPR screens |
ChiTaRSi | Agpat5, mouse |
PROi | PR:Q9D1E8 |
RNActi | Q9D1E8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031467, Expressed in zone of skin and 321 other tissues |
ExpressionAtlasi | Q9D1E8, baseline and differential |
Genevisiblei | Q9D1E8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCE_MOUSE | |
Accessioni | Q9D1E8Primary (citable) accession number: Q9D1E8 Secondary accession number(s): Q3U702, Q8BG61, Q8CGN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | May 16, 2003 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families