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Protein

Protein LMBR1L

Gene

Lmbr1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable receptor which may mediate endocytosis of its ligand.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LMBR1L
Alternative name(s):
Uteroglobin receptor
Gene namesi
Name:Lmbr1l
Synonyms:D15Ertd735e, Kiaa1174
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1289247 Lmbr1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 66CytoplasmicSequence analysisAdd BLAST24
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 114ExtracellularSequence analysisAdd BLAST27
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 196ExtracellularSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 305CytoplasmicSequence analysisAdd BLAST88
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 350ExtracellularSequence analysisAdd BLAST24
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 388CytoplasmicSequence analysisAdd BLAST17
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 431ExtracellularSequence analysisAdd BLAST22
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 489CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539121 – 489Protein LMBR1LAdd BLAST489

Proteomic databases

PaxDbiQ9D1E5
PRIDEiQ9D1E5

PTM databases

PhosphoSitePlusiQ9D1E5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022999 Expressed in 150 organ(s), highest expression level in testis
CleanExiMM_LMBR1L
GenevisibleiQ9D1E5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023736

Family & Domainsi

Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3722 Eukaryota
ENOG410YKEX LUCA
GeneTreeiENSGT00390000007809
HOGENOMiHOG000252995
HOVERGENiHBG072983
InParanoidiQ9D1E5
OMAiIIGNCVC
OrthoDBiEOG091G05XM
PhylomeDBiQ9D1E5
TreeFamiTF313485

Family and domain databases

InterProiView protein in InterPro
IPR008075 LIMR
IPR006876 LMBR1-like_membr_prot
PANTHERiPTHR12625 PTHR12625, 1 hit
PfamiView protein in Pfam
PF04791 LMBR1, 2 hits
PRINTSiPR01692 LIPOCALINIMR

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9D1E5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAADYEVLS VREQLFHDRV RECIISILLF ATLYILCHIF LTRFKKPAEF
60 70 80 90 100
TTVDDEDATV NKIALELCTF TLAVALGAVL LLPFSIISNE VLLSLPRNYY
110 120 130 140 150
IQWLNGSLIH GLWNLVFLFS NLSLVFLMPF AYFFTESEGF AGSRKGVLGR
160 170 180 190 200
VYETVVMLIL LTLLVLGMVW VASAIVDNDK ASRESLYDFW EYYLPYLYSC
210 220 230 240 250
ISFLGVLLLL VCTPLGLARM FSVTGKLLVK PRLLEDLEEQ LNCSAFEEAA
260 270 280 290 300
LTRRICNPTS CWLPLDMELL HRQVLALQAQ RVLLEKRRKA SAWQRNLGYP
310 320 330 340 350
LAMLCLLVLT GLSVLIVAVH ILELLIDEAA MPRGMQDAAL GQASFSKLGS
360 370 380 390 400
FGAIIQVVLI FYLMVSSVVG FYSSPLFGSL RPRWHDTSMT QIIGNCVCLL
410 420 430 440 450
VLSSALPVFS RTLGLTRFDL LGDFGRFNWL GNFYIVFLYN AAFAGLTTLC
460 470 480
LVKTFTAAVR AELIRAFGLD RLPLPVSGFP RASRKKQHQ
Length:489
Mass (Da):54,958
Last modified:June 1, 2001 - v1
Checksum:i50AA85EF2C58B79A
GO
Isoform 2 (identifier: Q9D1E5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):40,436
Checksum:i355918ADC596FF57
GO

Sequence cautioni

The sequence BAD32399 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88S → G in BAE41722 (PubMed:16141072).Curated1
Sequence conflicti303M → V in BAE41722 (PubMed:16141072).Curated1
Sequence conflicti357V → A in BAE41722 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0168971 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052398 mRNA Translation: AAL13076.1
AK173121 mRNA Translation: BAD32399.1 Different initiation.
AK003656 mRNA Translation: BAB22919.1
AK030589 mRNA Translation: BAC27033.1
AK049110 mRNA Translation: BAC33547.1
AK143891 mRNA Translation: BAE25586.1
AK154968 mRNA Translation: BAE32960.1
AK170328 mRNA Translation: BAE41722.1
BC023397 mRNA Translation: AAH23397.1
CCDSiCCDS27811.1 [Q9D1E5-1]
RefSeqiNP_083374.1, NM_029098.3 [Q9D1E5-1]
UniGeneiMm.385020

Genome annotation databases

EnsembliENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999 [Q9D1E5-1]
GeneIDi74775
KEGGimmu:74775
UCSCiuc007xoi.1 mouse [Q9D1E5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052398 mRNA Translation: AAL13076.1
AK173121 mRNA Translation: BAD32399.1 Different initiation.
AK003656 mRNA Translation: BAB22919.1
AK030589 mRNA Translation: BAC27033.1
AK049110 mRNA Translation: BAC33547.1
AK143891 mRNA Translation: BAE25586.1
AK154968 mRNA Translation: BAE32960.1
AK170328 mRNA Translation: BAE41722.1
BC023397 mRNA Translation: AAH23397.1
CCDSiCCDS27811.1 [Q9D1E5-1]
RefSeqiNP_083374.1, NM_029098.3 [Q9D1E5-1]
UniGeneiMm.385020

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023736

PTM databases

PhosphoSitePlusiQ9D1E5

Proteomic databases

PaxDbiQ9D1E5
PRIDEiQ9D1E5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023736; ENSMUSP00000023736; ENSMUSG00000022999 [Q9D1E5-1]
GeneIDi74775
KEGGimmu:74775
UCSCiuc007xoi.1 mouse [Q9D1E5-1]

Organism-specific databases

CTDi55716
MGIiMGI:1289247 Lmbr1l
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3722 Eukaryota
ENOG410YKEX LUCA
GeneTreeiENSGT00390000007809
HOGENOMiHOG000252995
HOVERGENiHBG072983
InParanoidiQ9D1E5
OMAiIIGNCVC
OrthoDBiEOG091G05XM
PhylomeDBiQ9D1E5
TreeFamiTF313485

Miscellaneous databases

PROiPR:Q9D1E5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022999 Expressed in 150 organ(s), highest expression level in testis
CleanExiMM_LMBR1L
GenevisibleiQ9D1E5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008075 LIMR
IPR006876 LMBR1-like_membr_prot
PANTHERiPTHR12625 PTHR12625, 1 hit
PfamiView protein in Pfam
PF04791 LMBR1, 2 hits
PRINTSiPR01692 LIPOCALINIMR
ProtoNetiSearch...

Entry informationi

Entry nameiLMBRL_MOUSE
AccessioniPrimary (citable) accession number: Q9D1E5
Secondary accession number(s): Q3TD82, Q69ZP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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