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Protein

Collagen triple helix repeat-containing protein 1

Gene

Cthrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a negative regulator of collagen matrix deposition.By similarity

GO - Molecular functioni

  • frizzled binding Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen triple helix repeat-containing protein 1
Gene namesi
Name:Cthrc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915838 Cthrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002103933 – 245Collagen triple helix repeat-containing protein 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D1D6
PaxDbiQ9D1D6
PRIDEiQ9D1D6

PTM databases

PhosphoSitePlusiQ9D1D6

Expressioni

Gene expression databases

BgeeiENSMUSG00000054196 Expressed in 305 organ(s), highest expression level in vault of skull
CleanExiMM_CTHRC1
GenevisibleiQ9D1D6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070018

Structurei

3D structure databases

ProteinModelPortaliQ9D1D6
SMRiQ9D1D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 92Collagen-likeAdd BLAST34

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IHSA Eukaryota
ENOG4111TT8 LUCA
GeneTreeiENSGT00390000018094
HOGENOMiHOG000237344
HOVERGENiHBG051218
InParanoidiQ9D1D6
OMAiSACCQRW
OrthoDBiEOG091G0HRY
TreeFamiTF328705

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9D1D6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPQGRAAPP QLLLGLFLVL LLLLQLSAPI SASENPKVKQ KALIRQREVV
60 70 80 90 100
DLYNGMCLQG PAGVPGRDGS PGANGIPGTP GIPGRDGFKG EKGECLRESF
110 120 130 140 150
EESWTPNYKQ CSWSSLNYGI DLGKIAECTF TKMRSNSALR VLFSGSLRLK
160 170 180 190 200
CRNACCQRWY FTFNGAECSG PLPIEAIIYL DQGSPELNST INIHRTSSVE
210 220 230 240
GLCEGIGAGL VDVAIWVGTC SDYPKGDAST GWNSVSRIII EELPK
Length:245
Mass (Da):26,460
Last modified:October 3, 2012 - v2
Checksum:iE4441BF70E4C8436
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPR1A0A2I3BPR1_MOUSE
Collagen triple helix repeat-contai...
Cthrc1
171Annotation score:
A0A2I3BRW6A0A2I3BRW6_MOUSE
Collagen triple helix repeat-contai...
Cthrc1
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41K → Q in BAB22930 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003674 mRNA Translation: BAB22930.1
AK151282 mRNA Translation: BAE30268.1
AC164883 Genomic DNA No translation available.
CH466541 Genomic DNA Translation: EDL08785.1
CCDSiCCDS27442.1
RefSeqiNP_081054.1, NM_026778.2
UniGeneiMm.41556

Genome annotation databases

EnsembliENSMUST00000067072; ENSMUSP00000070018; ENSMUSG00000054196
ENSMUST00000202235; ENSMUSP00000144506; ENSMUSG00000106929
GeneIDi68588
KEGGimmu:68588
UCSCiuc007voa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003674 mRNA Translation: BAB22930.1
AK151282 mRNA Translation: BAE30268.1
AC164883 Genomic DNA No translation available.
CH466541 Genomic DNA Translation: EDL08785.1
CCDSiCCDS27442.1
RefSeqiNP_081054.1, NM_026778.2
UniGeneiMm.41556

3D structure databases

ProteinModelPortaliQ9D1D6
SMRiQ9D1D6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070018

PTM databases

PhosphoSitePlusiQ9D1D6

Proteomic databases

MaxQBiQ9D1D6
PaxDbiQ9D1D6
PRIDEiQ9D1D6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067072; ENSMUSP00000070018; ENSMUSG00000054196
ENSMUST00000202235; ENSMUSP00000144506; ENSMUSG00000106929
GeneIDi68588
KEGGimmu:68588
UCSCiuc007voa.1 mouse

Organism-specific databases

CTDi115908
MGIiMGI:1915838 Cthrc1

Phylogenomic databases

eggNOGiENOG410IHSA Eukaryota
ENOG4111TT8 LUCA
GeneTreeiENSGT00390000018094
HOGENOMiHOG000237344
HOVERGENiHBG051218
InParanoidiQ9D1D6
OMAiSACCQRW
OrthoDBiEOG091G0HRY
TreeFamiTF328705

Miscellaneous databases

PROiPR:Q9D1D6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054196 Expressed in 305 organ(s), highest expression level in vault of skull
CleanExiMM_CTHRC1
GenevisibleiQ9D1D6 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTHR1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1D6
Secondary accession number(s): Q3UAP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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