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Protein

Ribosomal RNA-processing protein 7 homolog A

Gene

Rrp7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • blastocyst formation Source: MGI
  • ribosomal small subunit assembly Source: GO_Central
  • rRNA processing Source: GO_Central

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA-processing protein 7 homolog A
Alternative name(s):
Gastric cancer antigen Zg14 homolog
Gene namesi
Name:Rrp7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1922028 Rrp7a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820091 – 280Ribosomal RNA-processing protein 7 homolog AAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D1C9
MaxQBiQ9D1C9
PaxDbiQ9D1C9
PRIDEiQ9D1C9

PTM databases

iPTMnetiQ9D1C9
PhosphoSitePlusiQ9D1C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000018040 Expressed in 82 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9D1C9 baseline and differential
GenevisibleiQ9D1C9 MM

Interactioni

Protein-protein interaction databases

BioGridi217014, 1 interactor
IntActiQ9D1C9, 1 interactor
MINTiQ9D1C9
STRINGi10090.ENSMUSP00000018184

Structurei

3D structure databases

ProteinModelPortaliQ9D1C9
SMRiQ9D1C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 90RRMAdd BLAST30

Sequence similaritiesi

Belongs to the RRP7 family.Curated

Phylogenomic databases

eggNOGiKOG4008 Eukaryota
ENOG410YHJN LUCA
GeneTreeiENSGT00390000018482
HOGENOMiHOG000007041
HOVERGENiHBG054483
InParanoidiQ9D1C9
KOiK14545
OMAiFIRLMDP
OrthoDBiEOG091G0JTG
PhylomeDBiQ9D1C9
TreeFamiTF313949

Family and domain databases

CDDicd12294 RRM_Rrp7A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024326 RRP7
IPR034890 Rrp7A_RRM
PANTHERiPTHR13191 PTHR13191, 1 hit
PfamiView protein in Pfam
PF12923 RRP7, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D1C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSRRKKRKA GGHEESIPSP PGYSAVPVKF SAKQQAPHYL YMRQHRVRQG
60 70 80 90 100
TQSTWPPDRT LFILNVPPYC TQESLSRCLS CCGTIKTVEL QEKPDLAESP
110 120 130 140 150
TEPKSQFFHP KPVPGFQVAY VVFQKPSGVS AALNLKGPLL VSTESHLVKS
160 170 180 190 200
GIHKWISDYE DSVLDPEALR MEVDAFMEAY DKKIAEEEAK AKEEEGVPDE
210 220 230 240 250
EGWVKVTRRG RRPVLPRTEA ASLRVLEKEK RKRARKELLN FYAWQHRETK
260 270 280
MEHLAQLRKK FEEDKQRIEL MRAQRKFRPY
Length:280
Mass (Da):32,399
Last modified:June 1, 2001 - v1
Checksum:i4F2D324221B2AA3F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VVA3F6VVA3_MOUSE
Ribosomal RNA-processing protein 7 ...
Rrp7a
51Annotation score:
E9QAX0E9QAX0_MOUSE
Ribosomal RNA-processing protein 7 ...
Rrp7a
163Annotation score:
E9PYF0E9PYF0_MOUSE
Ribosomal RNA-processing protein 7 ...
Rrp7a
145Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103P → Q in BAC27942 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003698 mRNA Translation: BAB22944.1
AK032596 mRNA Translation: BAC27942.1
AK036247 mRNA Translation: BAC29360.1
AK088456 mRNA Translation: BAC40363.1
AK146821 mRNA Translation: BAE27459.1
AK159553 mRNA Translation: BAE35178.1
AK168189 mRNA Translation: BAE40149.1
AK168850 mRNA Translation: BAE40672.1
BC012523 mRNA Translation: AAH12523.1
CCDSiCCDS27696.1
RefSeqiNP_083377.3, NM_029101.4
UniGeneiMm.30056
Mm.452636

Genome annotation databases

EnsembliENSMUST00000018184; ENSMUSP00000018184; ENSMUSG00000018040
GeneIDi74778
KEGGimmu:74778
UCSCiuc007wzy.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003698 mRNA Translation: BAB22944.1
AK032596 mRNA Translation: BAC27942.1
AK036247 mRNA Translation: BAC29360.1
AK088456 mRNA Translation: BAC40363.1
AK146821 mRNA Translation: BAE27459.1
AK159553 mRNA Translation: BAE35178.1
AK168189 mRNA Translation: BAE40149.1
AK168850 mRNA Translation: BAE40672.1
BC012523 mRNA Translation: AAH12523.1
CCDSiCCDS27696.1
RefSeqiNP_083377.3, NM_029101.4
UniGeneiMm.30056
Mm.452636

3D structure databases

ProteinModelPortaliQ9D1C9
SMRiQ9D1C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217014, 1 interactor
IntActiQ9D1C9, 1 interactor
MINTiQ9D1C9
STRINGi10090.ENSMUSP00000018184

PTM databases

iPTMnetiQ9D1C9
PhosphoSitePlusiQ9D1C9

Proteomic databases

EPDiQ9D1C9
MaxQBiQ9D1C9
PaxDbiQ9D1C9
PRIDEiQ9D1C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018184; ENSMUSP00000018184; ENSMUSG00000018040
GeneIDi74778
KEGGimmu:74778
UCSCiuc007wzy.3 mouse

Organism-specific databases

CTDi27341
MGIiMGI:1922028 Rrp7a

Phylogenomic databases

eggNOGiKOG4008 Eukaryota
ENOG410YHJN LUCA
GeneTreeiENSGT00390000018482
HOGENOMiHOG000007041
HOVERGENiHBG054483
InParanoidiQ9D1C9
KOiK14545
OMAiFIRLMDP
OrthoDBiEOG091G0JTG
PhylomeDBiQ9D1C9
TreeFamiTF313949

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q9D1C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018040 Expressed in 82 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9D1C9 baseline and differential
GenevisibleiQ9D1C9 MM

Family and domain databases

CDDicd12294 RRM_Rrp7A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024326 RRP7
IPR034890 Rrp7A_RRM
PANTHERiPTHR13191 PTHR13191, 1 hit
PfamiView protein in Pfam
PF12923 RRP7, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRP7A_MOUSE
AccessioniPrimary (citable) accession number: Q9D1C9
Secondary accession number(s): Q3TWT8, Q8CCK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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