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Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.By similarity2 Publications

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Protein chibby homolog 1
Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene namesi
Name:Cby1
Synonyms:Cby, Pgea1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920989 Cby1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583551 – 127Protein chibby homolog 1Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D1C2
PaxDbiQ9D1C2
PeptideAtlasiQ9D1C2
PRIDEiQ9D1C2

PTM databases

iPTMnetiQ9D1C2
PhosphoSitePlusiQ9D1C2

Expressioni

Tissue specificityi

Found in heart, brain, lung, liver, muscle, kidney and testis. Levels are approximately 3-fold higher in embryonic and adult heart than in lung or liver.1 Publication

Developmental stagei

Ubiquitously expressed in early stages of embryonic stem cell differentiation but decreases at later stages when high expression is restricted to cardiomyocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000022428 Expressed in 256 organ(s), highest expression level in testis
CleanExiMM_CBY1
GenevisibleiQ9D1C2 MM

Interactioni

Subunit structurei

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilites targeting of FAM92A to cilium basal body.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216224, 3 interactors
IntActiQ9D1C2, 1 interactor
STRINGi10090.ENSMUSP00000023064

Structurei

3D structure databases

ProteinModelPortaliQ9D1C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 112Minimal region for the interaction with PKD2By similarityAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 110Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the chibby family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWV4 Eukaryota
ENOG4111NU6 LUCA
GeneTreeiENSGT00510000047043
HOGENOMiHOG000006694
HOVERGENiHBG050816
InParanoidiQ9D1C2
OMAiMPLFSNK
OrthoDBiEOG091G12BK
PhylomeDBiQ9D1C2
TreeFamiTF324419

Family and domain databases

CDDicd07429 Cby_like, 1 hit
InterProiView protein in InterPro
IPR028118 Chibby_fam
PfamiView protein in Pfam
PF14645 Chibby, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D1C2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ
60 70 80 90 100
SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD
110 120
MLSETTAESH LKDKELDELK VTNRRRK
Length:127
Mass (Da):14,535
Last modified:June 1, 2001 - v1
Checksum:i7CE38A48D045CCC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331040 mRNA Translation: AAL56061.1
AK003719 mRNA Translation: BAB22956.1
BC005733 mRNA Translation: AAH05733.1
CCDSiCCDS27645.1
RefSeqiNP_082910.1, NM_028634.3
UniGeneiMm.294441

Genome annotation databases

EnsembliENSMUST00000023064; ENSMUSP00000023064; ENSMUSG00000022428
GeneIDi73739
KEGGimmu:73739
UCSCiuc007wuc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331040 mRNA Translation: AAL56061.1
AK003719 mRNA Translation: BAB22956.1
BC005733 mRNA Translation: AAH05733.1
CCDSiCCDS27645.1
RefSeqiNP_082910.1, NM_028634.3
UniGeneiMm.294441

3D structure databases

ProteinModelPortaliQ9D1C2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216224, 3 interactors
IntActiQ9D1C2, 1 interactor
STRINGi10090.ENSMUSP00000023064

PTM databases

iPTMnetiQ9D1C2
PhosphoSitePlusiQ9D1C2

Proteomic databases

MaxQBiQ9D1C2
PaxDbiQ9D1C2
PeptideAtlasiQ9D1C2
PRIDEiQ9D1C2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023064; ENSMUSP00000023064; ENSMUSG00000022428
GeneIDi73739
KEGGimmu:73739
UCSCiuc007wuc.1 mouse

Organism-specific databases

CTDi25776
MGIiMGI:1920989 Cby1

Phylogenomic databases

eggNOGiENOG410IWV4 Eukaryota
ENOG4111NU6 LUCA
GeneTreeiENSGT00510000047043
HOGENOMiHOG000006694
HOVERGENiHBG050816
InParanoidiQ9D1C2
OMAiMPLFSNK
OrthoDBiEOG091G12BK
PhylomeDBiQ9D1C2
TreeFamiTF324419

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSiCby1 mouse
PROiPR:Q9D1C2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022428 Expressed in 256 organ(s), highest expression level in testis
CleanExiMM_CBY1
GenevisibleiQ9D1C2 MM

Family and domain databases

CDDicd07429 Cby_like, 1 hit
InterProiView protein in InterPro
IPR028118 Chibby_fam
PfamiView protein in Pfam
PF14645 Chibby, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBY1_MOUSE
AccessioniPrimary (citable) accession number: Q9D1C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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