Cby1

Functionⁱ

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.By similarity2 Publications

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
identical protein binding Source: MGI
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17261658
ciliary transition zone assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cilium assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 19364920
fat cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17403895
negative regulation of canonical Wnt signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 19364920
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of Wnt signaling pathway Source: MGI
protein homotetramerization Source: MGI
protein localization Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation, Differentiation

Biological process

Cilium biogenesis/degradation, Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Reactomeⁱ

R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein chibby homolog 1 Alternative name(s): Cytosolic leucine-rich protein PIGEA-14 PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene namesⁱ	Name:Cby1 Synonyms:Cby, Pgea1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1920989 Cby1

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058355	1 – 127	Protein chibby homolog 1Add BLAST		127

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	9	PhosphoserineBy similarity		1
Modified residueⁱ	20	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9D1C2
PaxDbⁱ	Q9D1C2
PeptideAtlas More...PeptideAtlasⁱ	Q9D1C2
PRIDEⁱ	Q9D1C2

PTM databases

iPTMnetⁱ	Q9D1C2
PhosphoSitePlusⁱ	Q9D1C2

Expressionⁱ

Tissue specificityⁱ

Found in heart, brain, lung, liver, muscle, kidney and testis. Levels are approximately 3-fold higher in embryonic and adult heart than in lung or liver.1 Publication

Developmental stageⁱ

Ubiquitously expressed in early stages of embryonic stem cell differentiation but decreases at later stages when high expression is restricted to cardiomyocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022428 Expressed in 256 organ(s), highest expression level in testis
CleanExⁱ	MM_CBY1
Genevisibleⁱ	Q9D1C2 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1. Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1. Interacts with FAM92A; this interaction facilites targeting of FAM92A to cilium basal body.By similarity

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
identical protein binding Source: MGI
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	216224, 3 interactors
IntActⁱ	Q9D1C2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000023064

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9D1C2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	60 – 112	Minimal region for the interaction with PKD2By similarityAdd BLAST		53

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 110	Sequence analysisAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the chibby family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IWV4 Eukaryota ENOG4111NU6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047043
HOGENOMⁱ	HOG000006694
HOVERGENⁱ	HBG050816
InParanoidⁱ	Q9D1C2
OMAⁱ	MPLFSNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12BK
PhylomeDBⁱ	Q9D1C2
TreeFamⁱ	TF324419

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07429 Cby_like, 1 hit
InterProⁱ	View protein in InterPro IPR028118 Chibby_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14645 Chibby, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9D1C2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ 
        60         70         80         90        100
SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD 
       110        120 
MLSETTAESH LKDKELDELK VTNRRRK

Length:127

Mass (Da):14,535

Last modified:June 1, 2001 - v1

Checksum:ⁱ7CE38A48D045CCC7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331040 mRNA Translation: AAL56061.1 AK003719 mRNA Translation: BAB22956.1 BC005733 mRNA Translation: AAH05733.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27645.1
NCBI Reference Sequences More...RefSeqⁱ	NP_082910.1, NM_028634.3
UniGeneⁱ	Mm.294441

Genome annotation databases

Ensemblⁱ	ENSMUST00000023064; ENSMUSP00000023064; ENSMUSG00000022428
GeneIDⁱ	73739
KEGGⁱ	mmu:73739
UCSC genome browser More...UCSCⁱ	uc007wuc.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9D1C2	Protein chibby homolog 1		RAT		127	UniRef90_Q9D1C2
protein chibby homolog 1		MESAU		127
UPI00022F5DBD		CRIGR		127
UPI000B4F7272		MERUN		127

Protein	Similar proteins		Species	Score	Length	Source
Q9D1C2	Protein chibby homolog 1		RAT		127	UniRef50_Q9D1C2
protein chibby homolog 1		MESAU		127
Uncharacterized protein		FICAL		126
Leucine-rich protein		DANRE		125
Chibby		PATMI		134
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331040 mRNA Translation: AAL56061.1 AK003719 mRNA Translation: BAB22956.1 BC005733 mRNA Translation: AAH05733.1
CCDSⁱ	CCDS27645.1
RefSeqⁱ	NP_082910.1, NM_028634.3
UniGeneⁱ	Mm.294441

3D structure databases

ProteinModelPortalⁱ	Q9D1C2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	216224, 3 interactors
IntActⁱ	Q9D1C2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000023064

PTM databases

iPTMnetⁱ	Q9D1C2
PhosphoSitePlusⁱ	Q9D1C2

Proteomic databases

MaxQBⁱ	Q9D1C2
PaxDbⁱ	Q9D1C2
PeptideAtlasⁱ	Q9D1C2
PRIDEⁱ	Q9D1C2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023064; ENSMUSP00000023064; ENSMUSG00000022428
GeneIDⁱ	73739
KEGGⁱ	mmu:73739
UCSCⁱ	uc007wuc.1 mouse

Organism-specific databases

CTDⁱ	25776
MGIⁱ	MGI:1920989 Cby1

Phylogenomic databases

eggNOGⁱ	ENOG410IWV4 Eukaryota ENOG4111NU6 LUCA
GeneTreeⁱ	ENSGT00510000047043
HOGENOMⁱ	HOG000006694
HOVERGENⁱ	HBG050816
InParanoidⁱ	Q9D1C2
OMAⁱ	MPLFSNK
OrthoDBⁱ	EOG091G12BK
PhylomeDBⁱ	Q9D1C2
TreeFamⁱ	TF324419

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Reactomeⁱ

R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSⁱ	Cby1 mouse
Protein Ontology More...PROⁱ	PR:Q9D1C2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022428 Expressed in 256 organ(s), highest expression level in testis
CleanExⁱ	MM_CBY1
Genevisibleⁱ	Q9D1C2 MM

Family and domain databases

CDDⁱ	cd07429 Cby_like, 1 hit
InterProⁱ	View protein in InterPro IPR028118 Chibby_fam
Pfamⁱ	View protein in Pfam PF14645 Chibby, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CBY1_MOUSE
Accessionⁱ	Q9D1C2Primary (citable) accession number: Q9D1C2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9D1C2 (CBY1_MOUSE)

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Protein chibby homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Golgi apparatus

Nucleus

Cytoskeleton

Golgi apparatus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ