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Entry version 127 (11 Dec 2019)
Sequence version 3 (24 Jan 2006)
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Protein

39S ribosomal protein L28, mitochondrial

Gene

Mrpl28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
39S ribosomal protein L28, mitochondrial
Short name:
L28mt
Short name:
MRP-L28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mrpl28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915861 Mrpl28

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 55MitochondrionBy similarityAdd BLAST55
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003050756 – 25739S ribosomal protein L28, mitochondrialAdd BLAST202

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9D1B9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9D1B9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D1B9

PeptideAtlas

More...
PeptideAtlasi
Q9D1B9

PRoteomics IDEntifications database

More...
PRIDEi
Q9D1B9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D1B9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D1B9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9D1B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024181 Expressed in 288 organ(s), highest expression level in cardiac muscle of left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9D1B9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D1B9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

Interacts with OXA1L.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025014

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9D1B9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9D1B9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3279 Eukaryota
ENOG410XQHX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017359

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010298

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D1B9

KEGG Orthology (KO)

More...
KOi
K02902

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSVVVTE

Database of Orthologous Groups

More...
OrthoDBi
1558223at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D1B9

TreeFam database of animal gene trees

More...
TreeFami
TF313040

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.170.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034704 L28p-like
IPR026569 Ribo_L28/L24
IPR037147 Ribo_L28/L24_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13528 PTHR13528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00830 Ribosomal_L28, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143800 SSF143800, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D1B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLHRYPVHL WQKLRLRQGI CARLPAHFLR SLEEERTPTP VHYKPHGTKF
60 70 80 90 100
KINPKNGQRE RVEDVPIPVH YPPESQQGLW GGEGLILGYR YANNDKLSKR
110 120 130 140 150
VKKVWKPQLF TRELYSEILD KKFTVTVTMR TLDLIDEAYG FDFYILKTPK
160 170 180 190 200
EDLGSKFGMD LKRGMLLRLA RQDPHLHPEN PERRAAIYDK YRSFVIPEAE
210 220 230 240 250
AEWVGLTLEE ALEKQRLLEE KDPVPLFKVY VEELVQRLQE QVLSRPAVVQ

KRAGDHA
Length:257
Mass (Da):30,170
Last modified:January 24, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC011BF7EF537996C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BBN2A0A494BBN2_MOUSE
39S ribosomal protein L28, mitochon...
Mrpl28
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U4U1F6U4U1_MOUSE
39S ribosomal protein L28, mitochon...
Mrpl28
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BB47A0A494BB47_MOUSE
39S ribosomal protein L28, mitochon...
Mrpl28
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02293 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH05797 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH80753 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI00323 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB22962 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32780 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK003727 mRNA Translation: BAB22962.2 Different initiation.
AK031701 mRNA Translation: BAC27521.1 Different initiation.
AK046544 mRNA Translation: BAC32780.1 Different initiation.
AK163190 mRNA Translation: BAE37227.1
BC002293 mRNA Translation: AAH02293.2 Different initiation.
BC005797 mRNA Translation: AAH05797.2 Different initiation.
BC080753 mRNA Translation: AAH80753.1 Different initiation.
BC100322 mRNA Translation: AAI00323.1 Different initiation.
BC145680 mRNA Translation: AAI45681.1
BC145682 mRNA Translation: AAI45683.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37509.1

NCBI Reference Sequences

More...
RefSeqi
NP_077189.2, NM_024227.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025014; ENSMUSP00000025014; ENSMUSG00000024181

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68611

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68611

UCSC genome browser

More...
UCSCi
uc008bdl.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003727 mRNA Translation: BAB22962.2 Different initiation.
AK031701 mRNA Translation: BAC27521.1 Different initiation.
AK046544 mRNA Translation: BAC32780.1 Different initiation.
AK163190 mRNA Translation: BAE37227.1
BC002293 mRNA Translation: AAH02293.2 Different initiation.
BC005797 mRNA Translation: AAH05797.2 Different initiation.
BC080753 mRNA Translation: AAH80753.1 Different initiation.
BC100322 mRNA Translation: AAI00323.1 Different initiation.
BC145680 mRNA Translation: AAI45681.1
BC145682 mRNA Translation: AAI45683.1
CCDSiCCDS37509.1
RefSeqiNP_077189.2, NM_024227.3

3D structure databases

SMRiQ9D1B9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025014

PTM databases

iPTMnetiQ9D1B9
PhosphoSitePlusiQ9D1B9
SwissPalmiQ9D1B9

Proteomic databases

EPDiQ9D1B9
MaxQBiQ9D1B9
PaxDbiQ9D1B9
PeptideAtlasiQ9D1B9
PRIDEiQ9D1B9

Genome annotation databases

EnsembliENSMUST00000025014; ENSMUSP00000025014; ENSMUSG00000024181
GeneIDi68611
KEGGimmu:68611
UCSCiuc008bdl.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10573
MGIiMGI:1915861 Mrpl28

Phylogenomic databases

eggNOGiKOG3279 Eukaryota
ENOG410XQHX LUCA
GeneTreeiENSGT00390000017359
HOGENOMiHOG000010298
InParanoidiQ9D1B9
KOiK02902
OMAiMSVVVTE
OrthoDBi1558223at2759
PhylomeDBiQ9D1B9
TreeFamiTF313040

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mrpl28 mouse

Protein Ontology

More...
PROi
PR:Q9D1B9
RNActiQ9D1B9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024181 Expressed in 288 organ(s), highest expression level in cardiac muscle of left ventricle
ExpressionAtlasiQ9D1B9 baseline and differential
GenevisibleiQ9D1B9 MM

Family and domain databases

Gene3Di2.30.170.40, 1 hit
InterProiView protein in InterPro
IPR034704 L28p-like
IPR026569 Ribo_L28/L24
IPR037147 Ribo_L28/L24_sf
PANTHERiPTHR13528 PTHR13528, 1 hit
PfamiView protein in Pfam
PF00830 Ribosomal_L28, 1 hit
SUPFAMiSSF143800 SSF143800, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRM28_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D1B9
Secondary accession number(s): A6H5Y0
, Q3TR04, Q497Y8, Q66JU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 24, 2006
Last modified: December 11, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
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