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Protein

Pre-mRNA-splicing factor SYF2

Gene

Syf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF2
Alternative name(s):
CCNDBP1-interactor
mp291 Publication
p291 Publication
Gene namesi
Name:Syf2
Synonyms:Cbpin, Gcipip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915842 Syf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002503772 – 242Pre-mRNA-splicing factor SYF2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9D198
MaxQBiQ9D198
PaxDbiQ9D198
PeptideAtlasiQ9D198
PRIDEiQ9D198

PTM databases

PhosphoSitePlusiQ9D198

Expressioni

Tissue specificityi

Abundantly expressed in the heart, liver and kidney. Expressed at lower level other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000028821 Expressed in 286 organ(s), highest expression level in embryo
CleanExiMM_SYF2
GenevisibleiQ9D198 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with CCNDBP1.By similarity

Protein-protein interaction databases

IntActiQ9D198, 1 interactor
STRINGi10090.ENSMUSP00000030622

Structurei

3D structure databases

ProteinModelPortaliQ9D198
SMRiQ9D198
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 91Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SYF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2609 Eukaryota
ENOG410XY86 LUCA
GeneTreeiENSGT00390000017845
HOGENOMiHOG000190170
HOVERGENiHBG080129
InParanoidiQ9D198
KOiK12868
OMAiRRRMHND
OrthoDBiEOG091G0MY0
PhylomeDBiQ9D198
TreeFamiTF313041

Family and domain databases

InterProiView protein in InterPro
IPR013260 mRNA_splic_SYF2
PANTHERiPTHR13264 PTHR13264, 1 hit
PfamiView protein in Pfam
PF08231 SYF2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVTEVVVP ADGAEARPLA AEELAAQKRE QRLRKFRELH LKRNEARKLN
60 70 80 90 100
HQEVVEEDKR LKLPANWEAK KARLEWELQE EEKKKECAAR GEDYEKVKLL
110 120 130 140 150
EISAEDAERW ERRKKKKNPD LGFSDYAAAQ LRQYHRLTKQ IKPDMESYER
160 170 180 190 200
QREKHGEDFF PTSNSLLHGT HVPSSEEIDR MVLDLEKQIE KRDKYSRRRP
210 220 230 240
YNDDADIDYI NERNAKFNKK AERFYGKYTA EIKQNLERGT AV
Length:242
Mass (Da):28,712
Last modified:June 1, 2001 - v1
Checksum:iFFCC25142541B847
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155574 Genomic DNA Translation: AAO06147.1
AY033432 mRNA Translation: AAK54459.1
AK003787 mRNA Translation: BAB22995.1
AK152794 mRNA Translation: BAE31500.1
BC051484 mRNA Translation: AAH51484.1
CCDSiCCDS18781.1
RefSeqiNP_081056.1, NM_026780.3
UniGeneiMm.29989

Genome annotation databases

EnsembliENSMUST00000030622; ENSMUSP00000030622; ENSMUSG00000028821
GeneIDi68592
KEGGimmu:68592
UCSCiuc008vga.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155574 Genomic DNA Translation: AAO06147.1
AY033432 mRNA Translation: AAK54459.1
AK003787 mRNA Translation: BAB22995.1
AK152794 mRNA Translation: BAE31500.1
BC051484 mRNA Translation: AAH51484.1
CCDSiCCDS18781.1
RefSeqiNP_081056.1, NM_026780.3
UniGeneiMm.29989

3D structure databases

ProteinModelPortaliQ9D198
SMRiQ9D198
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D198, 1 interactor
STRINGi10090.ENSMUSP00000030622

PTM databases

PhosphoSitePlusiQ9D198

Proteomic databases

EPDiQ9D198
MaxQBiQ9D198
PaxDbiQ9D198
PeptideAtlasiQ9D198
PRIDEiQ9D198

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030622; ENSMUSP00000030622; ENSMUSG00000028821
GeneIDi68592
KEGGimmu:68592
UCSCiuc008vga.1 mouse

Organism-specific databases

CTDi25949
MGIiMGI:1915842 Syf2

Phylogenomic databases

eggNOGiKOG2609 Eukaryota
ENOG410XY86 LUCA
GeneTreeiENSGT00390000017845
HOGENOMiHOG000190170
HOVERGENiHBG080129
InParanoidiQ9D198
KOiK12868
OMAiRRRMHND
OrthoDBiEOG091G0MY0
PhylomeDBiQ9D198
TreeFamiTF313041

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiSyf2 mouse
PROiPR:Q9D198
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028821 Expressed in 286 organ(s), highest expression level in embryo
CleanExiMM_SYF2
GenevisibleiQ9D198 MM

Family and domain databases

InterProiView protein in InterPro
IPR013260 mRNA_splic_SYF2
PANTHERiPTHR13264 PTHR13264, 1 hit
PfamiView protein in Pfam
PF08231 SYF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYF2_MOUSE
AccessioniPrimary (citable) accession number: Q9D198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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