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Protein

Integrator complex subunit 12

Gene

Ints12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 214PHD-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
Gene namesi
Name:Ints12
Synonyms:Phf22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919043 Ints12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593141 – 461Integrator complex subunit 12Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei127PhosphoserineBy similarity1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D168
MaxQBiQ9D168
PaxDbiQ9D168
PeptideAtlasiQ9D168
PRIDEiQ9D168

PTM databases

iPTMnetiQ9D168
PhosphoSitePlusiQ9D168

Expressioni

Gene expression databases

BgeeiENSMUSG00000028016 Expressed in 274 organ(s), highest expression level in primary oocyte
CleanExiMM_INTS12
GenevisibleiQ9D168 MM

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

IntActiQ9D168, 1 interactor
MINTiQ9D168
STRINGi10090.ENSMUSP00000029650

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9D168
SMRiQ9D168
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D168

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 439Ser-richAdd BLAST171

Sequence similaritiesi

Belongs to the Integrator subunit 12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 214PHD-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000005218
HOGENOMiHOG000059634
HOVERGENiHBG081798
InParanoidiQ9D168
KOiK13149
OMAiSSKHGHK
OrthoDBiEOG091G0KPP
PhylomeDBiQ9D168
TreeFamiTF106418

Family and domain databases

CDDicd15501 PHD_Int12, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039053 Int12
IPR039054 Int12_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13415 PTHR13415, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPT
60 70 80 90 100
QKDVEPPKIS STKSLSIKQE PKTSSSLPSG SSNGKVLTAE KIKKEAEKRP
110 120 130 140 150
ADKMKDVTEG IDVPKKPRLE KPETRSSPIT VQTSKDLSMA DLSSFEETSA
160 170 180 190 200
DDFAMEMGLA CVVCRQMTVA SGNQLVECQE CHNLYHQDCH KPQVTDKEVN
210 220 230 240 250
DPRLVWYCAR CTRQMKRMAQ KTQKPPQKPA PTVVSVTPTV KDPLVKKPET
260 270 280 290 300
KLKQETTFLA FKRTEVKPST VISGNSSSNN VSSSVTSGLT GWAAFAAKTS
310 320 330 340 350
SAGPSTAKLN SAAQNSSGKP AASSSNQKPV GLTGLATSSK GGIGSKIGSG
360 370 380 390 400
NSTSPSVPLK PLPPLTLGKT GLSRSVSCDN VSKVGLPSPS SLVPGGSSQL
410 420 430 440 450
SGNGNSATTG PSGSTTSKAT SETSSSTSAS LKGPTSQESQ LNAMKRLQMV
460
KKKAAQKKLK K
Length:461
Mass (Da):48,568
Last modified:June 1, 2001 - v1
Checksum:i9230385FBD4A9425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003874 mRNA Translation: BAB23052.1
AK155162 mRNA Translation: BAE33085.1
BC010657 mRNA Translation: AAH10657.1
BC023801 mRNA Translation: AAH23801.1
BC046996 mRNA Translation: AAH46996.1
CCDSiCCDS17848.1
RefSeqiNP_082203.1, NM_027927.4
UniGeneiMm.246726

Genome annotation databases

EnsembliENSMUST00000029650; ENSMUSP00000029650; ENSMUSG00000028016
GeneIDi71793
KEGGimmu:71793
UCSCiuc008rkj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003874 mRNA Translation: BAB23052.1
AK155162 mRNA Translation: BAE33085.1
BC010657 mRNA Translation: AAH10657.1
BC023801 mRNA Translation: AAH23801.1
BC046996 mRNA Translation: AAH46996.1
CCDSiCCDS17848.1
RefSeqiNP_082203.1, NM_027927.4
UniGeneiMm.246726

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEVNMR-A150-224[»]
ProteinModelPortaliQ9D168
SMRiQ9D168
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D168, 1 interactor
MINTiQ9D168
STRINGi10090.ENSMUSP00000029650

PTM databases

iPTMnetiQ9D168
PhosphoSitePlusiQ9D168

Proteomic databases

EPDiQ9D168
MaxQBiQ9D168
PaxDbiQ9D168
PeptideAtlasiQ9D168
PRIDEiQ9D168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029650; ENSMUSP00000029650; ENSMUSG00000028016
GeneIDi71793
KEGGimmu:71793
UCSCiuc008rkj.1 mouse

Organism-specific databases

CTDi57117
MGIiMGI:1919043 Ints12

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000005218
HOGENOMiHOG000059634
HOVERGENiHBG081798
InParanoidiQ9D168
KOiK13149
OMAiSSKHGHK
OrthoDBiEOG091G0KPP
PhylomeDBiQ9D168
TreeFamiTF106418

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

EvolutionaryTraceiQ9D168
PROiPR:Q9D168
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028016 Expressed in 274 organ(s), highest expression level in primary oocyte
CleanExiMM_INTS12
GenevisibleiQ9D168 MM

Family and domain databases

CDDicd15501 PHD_Int12, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039053 Int12
IPR039054 Int12_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13415 PTHR13415, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT12_MOUSE
AccessioniPrimary (citable) accession number: Q9D168
Secondary accession number(s): Q3U2Q5, Q921U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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