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Protein

Leukocyte elastase inhibitor A

Gene

Serpinb1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the activity of the neutrophil proteases and thus, forms complexes with chymotrypsin, elastase, cathepsin G and proteinase-3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344 – 345Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI04.006

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor A
Alternative name(s):
Serine protease inhibitor EIA
Serpin B1a
Gene namesi
Name:Serpinb1a
Synonyms:Serpinb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913472 Serpinb1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891201 – 379Leukocyte elastase inhibitor AAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D154
MaxQBiQ9D154
PaxDbiQ9D154
PeptideAtlasiQ9D154
PRIDEiQ9D154

2D gel databases

UCD-2DPAGEiQ9D154

PTM databases

iPTMnetiQ9D154
PhosphoSitePlusiQ9D154

Expressioni

Tissue specificityi

Ubiquitous with higher expression in pancreas, spleen and bone marrow.2 Publications

Gene expression databases

BgeeiENSMUSG00000044734 Expressed in 241 organ(s), highest expression level in ileum
ExpressionAtlasiQ9D154 baseline and differential
GenevisibleiQ9D154 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi211307, 6 interactors
IntActiQ9D154, 1 interactor
MINTiQ9D154
STRINGi10090.ENSMUSP00000075690

Structurei

3D structure databases

ProteinModelPortaliQ9D154
SMRiQ9D154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9D154
KOiK13963
OMAiGMVAFCM
OrthoDBiEOG091G0ION
PhylomeDBiQ9D154
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR015557 Serpin_B1
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF180 PTHR11461:SF180, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQLSSANTL FALELFQTLN ESSPTGNIFF SPFSISSALA MVILGAKGST
60 70 80 90 100
AAQLSKTFHF DSVEDIHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF
110 120 130 140 150
LPEYLASTQK MYGADLAPVD FLHASEDARK EINQWVKGQT EGKIPELLSV
160 170 180 190 200
GVVDSMTKLV LVNAIYFKGM WEEKFMTEDT TDAPFRLSKK DTKTVKMMYQ
210 220 230 240 250
KKKFPFGYIS DLKCKVLEMP YQGGELSMVI LLPKDIEDES TGLKKIEKQI
260 270 280 290 300
TLEKLLEWTK RENLEFIDVH VKLPRFKIEE SYTLNSNLGR LGVQDLFSSS
310 320 330 340 350
KADLSGMSGS RDLFISKIVH KSFVEVNEEG TEAAAATGGI ATFCMLLPEE
360 370
EFTVDHPFIF FIRHNPTSNV LFLGRVCSP
Length:379
Mass (Da):42,575
Last modified:June 1, 2001 - v1
Checksum:iF492F1EEB88E80B1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YK03Z4YK03_MOUSE
Leukocyte elastase inhibitor A
Serpinb1a
188Annotation score:

Sequence cautioni

The sequence BAB23335 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAI25648 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73L → Q in BAB25964 (PubMed:16141072).Curated1
Sequence conflicti146E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti154D → N in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti189K → R in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti193K → R in BAB25964 (PubMed:16141072).Curated1
Sequence conflicti261R → L in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti265E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti280E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti290R → P in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti301K → E in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti313L → S in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti319V → P in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti324V → F in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti341A → V in BAE35797 (PubMed:16141072).Curated1
Sequence conflicti362I → M in BAB23335 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426024 mRNA Translation: AAL57486.1
AF521697 Genomic DNA Translation: AAM95933.1
AK003930 mRNA Translation: BAB23079.1
AK004500 mRNA Translation: BAB23335.1 Frameshift.
AK008914 mRNA Translation: BAB25964.1
AK160167 mRNA Translation: BAE35668.1
AK160456 mRNA Translation: BAE35797.1
AL645808 Genomic DNA Translation: CAI25648.1 Sequence problems.
BC011140 mRNA Translation: AAH11140.1
BC104333 mRNA Translation: AAI04334.1
CCDSiCCDS26428.1
RefSeqiNP_079705.2, NM_025429.2
XP_006516787.1, XM_006516724.1
UniGeneiMm.20144

Genome annotation databases

EnsembliENSMUST00000076352; ENSMUSP00000075690; ENSMUSG00000044734
GeneIDi66222
KEGGimmu:66222
UCSCiuc007pzu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426024 mRNA Translation: AAL57486.1
AF521697 Genomic DNA Translation: AAM95933.1
AK003930 mRNA Translation: BAB23079.1
AK004500 mRNA Translation: BAB23335.1 Frameshift.
AK008914 mRNA Translation: BAB25964.1
AK160167 mRNA Translation: BAE35668.1
AK160456 mRNA Translation: BAE35797.1
AL645808 Genomic DNA Translation: CAI25648.1 Sequence problems.
BC011140 mRNA Translation: AAH11140.1
BC104333 mRNA Translation: AAI04334.1
CCDSiCCDS26428.1
RefSeqiNP_079705.2, NM_025429.2
XP_006516787.1, XM_006516724.1
UniGeneiMm.20144

3D structure databases

ProteinModelPortaliQ9D154
SMRiQ9D154
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211307, 6 interactors
IntActiQ9D154, 1 interactor
MINTiQ9D154
STRINGi10090.ENSMUSP00000075690

Protein family/group databases

MEROPSiI04.006

PTM databases

iPTMnetiQ9D154
PhosphoSitePlusiQ9D154

2D gel databases

UCD-2DPAGEiQ9D154

Proteomic databases

EPDiQ9D154
MaxQBiQ9D154
PaxDbiQ9D154
PeptideAtlasiQ9D154
PRIDEiQ9D154

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076352; ENSMUSP00000075690; ENSMUSG00000044734
GeneIDi66222
KEGGimmu:66222
UCSCiuc007pzu.1 mouse

Organism-specific databases

CTDi66222
MGIiMGI:1913472 Serpinb1a

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9D154
KOiK13963
OMAiGMVAFCM
OrthoDBiEOG091G0ION
PhylomeDBiQ9D154
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q9D154
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044734 Expressed in 241 organ(s), highest expression level in ileum
ExpressionAtlasiQ9D154 baseline and differential
GenevisibleiQ9D154 MM

Family and domain databases

InterProiView protein in InterPro
IPR015557 Serpin_B1
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF180 PTHR11461:SF180, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiILEUA_MOUSE
AccessioniPrimary (citable) accession number: Q9D154
Secondary accession number(s): Q3TV23
, Q5SUV7, Q9D0S8, Q9D7S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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