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Protein

Uroplakin-1a

Gene

Upk1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1a
Short name:
UP1a
Alternative name(s):
Uroplakin Ia
Short name:
UPIa
Short name:
UPKa
Gene namesi
Name:Upk1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98911 Upk1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 58ExtracellularSequence analysisAdd BLAST24
Transmembranei59 – 85HelicalSequence analysisAdd BLAST27
Topological domaini86 – 90CytoplasmicSequence analysis5
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 229ExtracellularSequence analysisAdd BLAST118
Transmembranei230 – 251HelicalSequence analysisAdd BLAST22
Topological domaini252 – 257CytoplasmicSequence analysis6

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192871 – 257Uroplakin-1aAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D132
PRIDEiQ9D132

Expressioni

Gene expression databases

BgeeiENSMUSG00000006313 Expressed in 141 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK1A
ExpressionAtlasiQ9D132 baseline and differential
GenevisibleiQ9D132 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2) (By similarity). Binds to uropathogenic E.coli fimH.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006476

Structurei

3D structure databases

ProteinModelPortaliQ9D132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiQ9D132
KOiK17347
OMAiRSMILTY
OrthoDBiEOG091G0G8N
PhylomeDBiQ9D132
TreeFamiTF335659

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034765 Uroplakin-1a
PANTHERiPTHR19282:SF25 PTHR19282:SF25, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D132-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAATEGEK GSPVVVGLLV VGNIIILLSG LALFAETVWV TADQYRVYPL
60 70 80 90 100
MGVSGKDDVF AGAWIAIFCG FSFFVVASFG VGAALCRRRY MILTYLLLML
110 120 130 140 150
IVYIFECASC ITSYTHRDYM VSNPSLITKQ MLTYYSADTD QGQELTRLWD
160 170 180 190 200
RIMIEQECCG TSGPMDWVNY TSAFRAATPE VVFPWPPLCC RRTGNFIPIN
210 220 230 240 250
EDGCRVGHMD YLFTKGCFEH IGHAIDSYTW GISWFGFAIL MWTLPVMLIA

MYFYTTL
Length:257
Mass (Da):28,854
Last modified:June 1, 2001 - v1
Checksum:i882215F25A5848ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262335 mRNA Translation: AAM08129.1
AK004014 mRNA Translation: BAB23125.1
CCDSiCCDS21103.1
RefSeqiNP_081091.1, NM_026815.2
UniGeneiMm.25471

Genome annotation databases

EnsembliENSMUST00000006476; ENSMUSP00000006476; ENSMUSG00000006313
GeneIDi109637
KEGGimmu:109637
UCSCiuc009gfk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262335 mRNA Translation: AAM08129.1
AK004014 mRNA Translation: BAB23125.1
CCDSiCCDS21103.1
RefSeqiNP_081091.1, NM_026815.2
UniGeneiMm.25471

3D structure databases

ProteinModelPortaliQ9D132
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006476

Proteomic databases

PaxDbiQ9D132
PRIDEiQ9D132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006476; ENSMUSP00000006476; ENSMUSG00000006313
GeneIDi109637
KEGGimmu:109637
UCSCiuc009gfk.2 mouse

Organism-specific databases

CTDi11045
MGIiMGI:98911 Upk1a

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiQ9D132
KOiK17347
OMAiRSMILTY
OrthoDBiEOG091G0G8N
PhylomeDBiQ9D132
TreeFamiTF335659

Miscellaneous databases

PROiPR:Q9D132
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006313 Expressed in 141 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_UPK1A
ExpressionAtlasiQ9D132 baseline and differential
GenevisibleiQ9D132 MM

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034765 Uroplakin-1a
PANTHERiPTHR19282:SF25 PTHR19282:SF25, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK1A_MOUSE
AccessioniPrimary (citable) accession number: Q9D132
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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