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Protein

Insulin-like growth factor-binding protein 3 receptor

Gene

Tmem219

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803211 TP53 Regulates Transcription of Death Receptors and Ligands

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3 receptor
Short name:
IGFBP-3R
Alternative name(s):
Transmembrane protein 219
Gene namesi
Name:Tmem219
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915992 Tmem219

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 204ExtracellularSequence analysisAdd BLAST166
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 240CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000032905039 – 240Insulin-like growth factor-binding protein 3 receptorAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D123
PRIDEiQ9D123

PTM databases

PhosphoSitePlusiQ9D123

Expressioni

Gene expression databases

BgeeiENSMUSG00000060538 Expressed in 227 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9D123 baseline and differential
GenevisibleiQ9D123 MM

Interactioni

Subunit structurei

Interacts with IGFBP3. Interacts with CASP8 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D123, 1 interactor
STRINGi10090.ENSMUSP00000032926

Structurei

3D structure databases

ProteinModelPortaliQ9D123
SMRiQ9D123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 32Poly-Leu8

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWEC Eukaryota
ENOG4110155 LUCA
GeneTreeiENSGT00390000013671
HOGENOMiHOG000154627
HOVERGENiHBG095163
InParanoidiQ9D123
TreeFamiTF338507

Family and domain databases

InterProiView protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom
PANTHERiPTHR16002 PTHR16002, 1 hit
PfamiView protein in Pfam
PF14940 TMEM219, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGGF LLTHTTGLRS
60 70 80 90 100
PDIPQDWVSF LRSFGQLSLC PMNETVTGTW QGPHVVGLLT TLNFGDGPDR
110 120 130 140 150
NKTQTFQAKI HGSQIGLTGS SAGESVLVTA RVASGRTPGT CLYFSGVPKV
160 170 180 190 200
LPSSQPPISC SEEGVGNATL SPVMGEECVR VWSHERLVLT ELLTSEELAL
210 220 230 240
CGSRVLGLGF FLVLLCGLLC CTTAVCFHPR PEFHWSRTRL
Length:240
Mass (Da):25,573
Last modified:June 1, 2001 - v1
Checksum:iE3BBDE977F1A4952
GO
Isoform 2 (identifier: Q9D123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     196-198: EEL → VSA
     199-240: Missing.

Show »
Length:127
Mass (Da):13,283
Checksum:i6F38194DCFDB8E13
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8V1G5E8V1_MOUSE
Insulin-like growth factor-binding ...
Tmem219 mCG_22386
265Annotation score:
D3Z3J3D3Z3J3_MOUSE
Insulin-like growth factor-binding ...
Tmem219
221Annotation score:
G3X9Z3G3X9Z3_MOUSE
Insulin-like growth factor-binding ...
Tmem219 mCG_22386
272Annotation score:
D3Z6H6D3Z6H6_MOUSE
Insulin-like growth factor-binding ...
Tmem219
136Annotation score:
H3BK56H3BK56_MOUSE
Insulin-like growth factor-binding ...
Tmem219
150Annotation score:
F6VVM1F6VVM1_MOUSE
Insulin-like growth factor-binding ...
Tmem219
82Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0329321 – 71Missing in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_032933196 – 198EEL → VSA in isoform 2. 1 Publication3
Alternative sequenceiVSP_032934199 – 240Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004043 mRNA Translation: BAB23139.1
AK013646 mRNA Translation: BAB28936.1
AK152526 mRNA Translation: BAE31285.1
BC023442 mRNA Translation: AAH23442.1
BC046763 mRNA Translation: AAH46763.1
CCDSiCCDS40133.1 [Q9D123-1]
RefSeqiNP_081103.1, NM_026827.1 [Q9D123-1]
NP_082665.1, NM_028389.1 [Q9D123-1]
XP_006508220.1, XM_006508157.3 [Q9D123-1]
XP_006508221.1, XM_006508158.3 [Q9D123-1]
UniGeneiMm.248646

Genome annotation databases

EnsembliENSMUST00000032926; ENSMUSP00000032926; ENSMUSG00000060538 [Q9D123-1]
ENSMUST00000121532; ENSMUSP00000112485; ENSMUSG00000060538 [Q9D123-1]
GeneIDi68742
KEGGimmu:68742
UCSCiuc009jtj.1 mouse [Q9D123-1]
uc009jtl.1 mouse [Q9D123-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004043 mRNA Translation: BAB23139.1
AK013646 mRNA Translation: BAB28936.1
AK152526 mRNA Translation: BAE31285.1
BC023442 mRNA Translation: AAH23442.1
BC046763 mRNA Translation: AAH46763.1
CCDSiCCDS40133.1 [Q9D123-1]
RefSeqiNP_081103.1, NM_026827.1 [Q9D123-1]
NP_082665.1, NM_028389.1 [Q9D123-1]
XP_006508220.1, XM_006508157.3 [Q9D123-1]
XP_006508221.1, XM_006508158.3 [Q9D123-1]
UniGeneiMm.248646

3D structure databases

ProteinModelPortaliQ9D123
SMRiQ9D123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D123, 1 interactor
STRINGi10090.ENSMUSP00000032926

PTM databases

PhosphoSitePlusiQ9D123

Proteomic databases

PaxDbiQ9D123
PRIDEiQ9D123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032926; ENSMUSP00000032926; ENSMUSG00000060538 [Q9D123-1]
ENSMUST00000121532; ENSMUSP00000112485; ENSMUSG00000060538 [Q9D123-1]
GeneIDi68742
KEGGimmu:68742
UCSCiuc009jtj.1 mouse [Q9D123-1]
uc009jtl.1 mouse [Q9D123-2]

Organism-specific databases

CTDi124446
MGIiMGI:1915992 Tmem219

Phylogenomic databases

eggNOGiENOG410IWEC Eukaryota
ENOG4110155 LUCA
GeneTreeiENSGT00390000013671
HOGENOMiHOG000154627
HOVERGENiHBG095163
InParanoidiQ9D123
TreeFamiTF338507

Enzyme and pathway databases

ReactomeiR-MMU-6803211 TP53 Regulates Transcription of Death Receptors and Ligands

Miscellaneous databases

PROiPR:Q9D123
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060538 Expressed in 227 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9D123 baseline and differential
GenevisibleiQ9D123 MM

Family and domain databases

InterProiView protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom
PANTHERiPTHR16002 PTHR16002, 1 hit
PfamiView protein in Pfam
PF14940 TMEM219, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTM219_MOUSE
AccessioniPrimary (citable) accession number: Q9D123
Secondary accession number(s): Q9D6H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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