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Protein

Protein phosphatase 1 regulatory subunit 27

Gene

Ppp1r27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 27
Alternative name(s):
Dysferlin-interacting protein 1
Gene namesi
Name:Ppp1r27
Synonyms:Dysfip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915951 Ppp1r27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644701 – 154Protein phosphatase 1 regulatory subunit 27Add BLAST154

Proteomic databases

PaxDbiQ9D119
PRIDEiQ9D119

PTM databases

iPTMnetiQ9D119
PhosphoSitePlusiQ9D119

Expressioni

Gene expression databases

BgeeiENSMUSG00000025129 Expressed in 49 organ(s), highest expression level in soleus muscle
CleanExiMM_DYSFIP1
GenevisibleiQ9D119 MM

Interactioni

Subunit structurei

Interacts with DYSF and PPP1CA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026121

Structurei

3D structure databases

ProteinModelPortaliQ9D119
SMRiQ9D119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 92ANK 1Add BLAST30
Repeati96 – 125ANK 2Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000231238
HOVERGENiHBG080189
InParanoidiQ9D119
KOiK17566
OMAiHFPNDVV
OrthoDBiEOG091G0U5T
PhylomeDBiQ9D119
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q9D119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRTVRYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI
60 70 80 90 100
RARKVSLDTI HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDETGWTP
110 120 130 140 150
LHIACSDGYP DIARYLISLG ADRDAANDDG DLPSDLIDPD FKDLVELFKG

TSMD
Length:154
Mass (Da):17,436
Last modified:June 1, 2001 - v1
Checksum:iF7D11438056CAA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004064 mRNA Translation: BAB23150.1
AL663030 Genomic DNA No translation available.
BC115957 mRNA Translation: AAI15958.1
CCDSiCCDS36392.1
RefSeqiNP_081090.1, NM_026814.3
UniGeneiMm.46477

Genome annotation databases

EnsembliENSMUST00000026121; ENSMUSP00000026121; ENSMUSG00000025129
GeneIDi68701
KEGGimmu:68701
UCSCiuc007mth.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004064 mRNA Translation: BAB23150.1
AL663030 Genomic DNA No translation available.
BC115957 mRNA Translation: AAI15958.1
CCDSiCCDS36392.1
RefSeqiNP_081090.1, NM_026814.3
UniGeneiMm.46477

3D structure databases

ProteinModelPortaliQ9D119
SMRiQ9D119
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026121

PTM databases

iPTMnetiQ9D119
PhosphoSitePlusiQ9D119

Proteomic databases

PaxDbiQ9D119
PRIDEiQ9D119

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026121; ENSMUSP00000026121; ENSMUSG00000025129
GeneIDi68701
KEGGimmu:68701
UCSCiuc007mth.1 mouse

Organism-specific databases

CTDi116729
MGIiMGI:1915951 Ppp1r27

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000231238
HOVERGENiHBG080189
InParanoidiQ9D119
KOiK17566
OMAiHFPNDVV
OrthoDBiEOG091G0U5T
PhylomeDBiQ9D119
TreeFamiTF333311

Miscellaneous databases

PROiPR:Q9D119
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025129 Expressed in 49 organ(s), highest expression level in soleus muscle
CleanExiMM_DYSFIP1
GenevisibleiQ9D119 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPPR27_MOUSE
AccessioniPrimary (citable) accession number: Q9D119
Secondary accession number(s): A2ABX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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