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Entry version 107 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Transmembrane protein 53

Gene

Tmem53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
mouse-tmm53 Duf_829

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 53
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem53
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916027 Tmem53

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei170 – 190HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002841191 – 276Transmembrane protein 53Add BLAST276

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D0Z3

PRoteomics IDEntifications database

More...
PRIDEi
Q9D0Z3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D0Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D0Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048772 Expressed in 130 organ(s), highest expression level in seminiferous tubule of testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9D0Z3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D0Z3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061523

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM53 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2521 Eukaryota
ENOG4111184 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000715

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230532

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D0Z3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SNGGFML

Database of Orthologous Groups

More...
OrthoDBi
916101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D0Z3

TreeFam database of animal gene trees

More...
TreeFami
TF313176

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR008547 DUF829_TMEM53

The PANTHER Classification System

More...
PANTHERi
PTHR12265 PTHR12265, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05705 DUF829, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D0Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAELDYSI EIPDQPCWSQ KNRQGGKEAG KQQPVVILLG WGGCRDKNLA
60 70 80 90 100
KYSAIYHKRG CIVIRYTAPW HMVFFSESLG IPSLRVIAQK LLELLFDYEI
110 120 130 140 150
EREPLLFHVF SNAGVMLYRY VLELLQTHQR FRHLHVVGTI FDSGPGDSNL
160 170 180 190 200
IGALRALATI LERRPAVLRL LLLAAFALVV ILFHFLLAPF TALFHTHFYD
210 220 230 240 250
RLQDSGSCWP ELYLYSRADK VVSARDVERM VEARLAHQVM VRGVDFVSSA
260 270
HVSHLRDYPT YYTSLCVDFM HNCVQC
Length:276
Mass (Da):31,589
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58FF99CF4A580CE9
GO
Isoform 2 (identifier: Q9D0Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: K → SMEGDWEE

Show »
Length:283
Mass (Da):32,425
Checksum:iAF26DD02F200CA6A
GO
Isoform 3 (identifier: Q9D0Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.
     16-20: PCWSQ → MNPDG

Show »
Length:261
Mass (Da):29,838
Checksum:iBE6149ADC976092A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQK8A0A0A0MQK8_MOUSE
Transmembrane protein 53
Tmem53
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0244471 – 15Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_02444816 – 20PCWSQ → MNPDG in isoform 3. 1 Publication5
Alternative sequenceiVSP_02444921K → SMEGDWEE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK004164 mRNA Translation: BAB23200.1
AK005885 mRNA Translation: BAB24300.1
AL671866 Genomic DNA No translation available.
AL844169 Genomic DNA No translation available.
BC019937 mRNA Translation: AAH19937.1
BC020121 mRNA Translation: AAH20121.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18533.1 [Q9D0Z3-1]
CCDS71453.1 [Q9D0Z3-2]
CCDS71454.1 [Q9D0Z3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001272741.1, NM_001285812.1 [Q9D0Z3-2]
NP_001272743.1, NM_001285814.1 [Q9D0Z3-3]
NP_001272744.1, NM_001285815.1
NP_001272745.1, NM_001285816.1
NP_081113.1, NM_026837.3 [Q9D0Z3-1]
NP_083865.1, NM_029589.1 [Q9D0Z3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062824; ENSMUSP00000061523; ENSMUSG00000048772 [Q9D0Z3-1]
ENSMUST00000106433; ENSMUSP00000102041; ENSMUSG00000048772 [Q9D0Z3-3]
ENSMUST00000106434; ENSMUSP00000102042; ENSMUSG00000048772 [Q9D0Z3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68777

UCSC genome browser

More...
UCSCi
uc008uii.2 mouse [Q9D0Z3-1]
uc008uij.2 mouse [Q9D0Z3-2]
uc008uik.2 mouse [Q9D0Z3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004164 mRNA Translation: BAB23200.1
AK005885 mRNA Translation: BAB24300.1
AL671866 Genomic DNA No translation available.
AL844169 Genomic DNA No translation available.
BC019937 mRNA Translation: AAH19937.1
BC020121 mRNA Translation: AAH20121.1
CCDSiCCDS18533.1 [Q9D0Z3-1]
CCDS71453.1 [Q9D0Z3-2]
CCDS71454.1 [Q9D0Z3-3]
RefSeqiNP_001272741.1, NM_001285812.1 [Q9D0Z3-2]
NP_001272743.1, NM_001285814.1 [Q9D0Z3-3]
NP_001272744.1, NM_001285815.1
NP_001272745.1, NM_001285816.1
NP_081113.1, NM_026837.3 [Q9D0Z3-1]
NP_083865.1, NM_029589.1 [Q9D0Z3-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061523

Protein family/group databases

ESTHERimouse-tmm53 Duf_829

PTM databases

iPTMnetiQ9D0Z3
PhosphoSitePlusiQ9D0Z3

Proteomic databases

PaxDbiQ9D0Z3
PRIDEiQ9D0Z3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062824; ENSMUSP00000061523; ENSMUSG00000048772 [Q9D0Z3-1]
ENSMUST00000106433; ENSMUSP00000102041; ENSMUSG00000048772 [Q9D0Z3-3]
ENSMUST00000106434; ENSMUSP00000102042; ENSMUSG00000048772 [Q9D0Z3-2]
GeneIDi68777
KEGGimmu:68777
UCSCiuc008uii.2 mouse [Q9D0Z3-1]
uc008uij.2 mouse [Q9D0Z3-2]
uc008uik.2 mouse [Q9D0Z3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79639
MGIiMGI:1916027 Tmem53

Phylogenomic databases

eggNOGiKOG2521 Eukaryota
ENOG4111184 LUCA
GeneTreeiENSGT00390000000715
HOGENOMiHOG000230532
InParanoidiQ9D0Z3
OMAiSNGGFML
OrthoDBi916101at2759
PhylomeDBiQ9D0Z3
TreeFamiTF313176

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9D0Z3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048772 Expressed in 130 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ9D0Z3 baseline and differential
GenevisibleiQ9D0Z3 MM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008547 DUF829_TMEM53
PANTHERiPTHR12265 PTHR12265, 1 hit
PfamiView protein in Pfam
PF05705 DUF829, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM53_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D0Z3
Secondary accession number(s): A2AE66, Q8VDW5, Q9DAF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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