Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ARV1

Gene

Arv1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).1 Publication

GO - Biological processi

  • bile acid metabolic process Source: MGI
  • cholesterol metabolic process Source: UniProtKB-KW
  • cholesterol transport Source: MGI
  • intracellular sterol transport Source: GO_Central
  • regulation of cholesterol metabolic process Source: MGI
  • regulation of intracellular cholesterol transport Source: UniProtKB
  • regulation of plasma membrane sterol distribution Source: GO_Central
  • sphingolipid metabolic process Source: GO_Central
  • sterol metabolic process Source: GO_Central

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ARV1
Gene namesi
Name:Arv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916115 Arv1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show an increase in the abundance of type 1 oxidative muscle fibers in the diaphragm. Female mice show also an increase in the abundance of type 1 muscle fibers in the extensor digitorum longus. Conditional knockout in neurons leads to decreased body mass; male show reduced white adipose tissue mass while female show reduced perigonadal fat mass. Show also abnormal circling behavior and severe seizures.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002286601 – 266Protein ARV1Add BLAST266

Proteomic databases

EPDiQ9D0U9
MaxQBiQ9D0U9
PaxDbiQ9D0U9
PRIDEiQ9D0U9

PTM databases

PhosphoSitePlusiQ9D0U9

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000031982 Expressed in 149 organ(s), highest expression level in optic fissure
CleanExiMM_ARV1
ExpressionAtlasiQ9D0U9 baseline and differential
GenevisibleiQ9D0U9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034463

Structurei

3D structure databases

ProteinModelPortaliQ9D0U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARV1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3134 Eukaryota
COG5254 LUCA
GeneTreeiENSGT00390000002675
HOGENOMiHOG000013218
HOVERGENiHBG080869
InParanoidiQ9D0U9
KOiK21848
OMAiYFFQRME
OrthoDBiEOG091G0RKK
PhylomeDBiQ9D0U9
TreeFamiTF105845

Family and domain databases

InterProiView protein in InterPro
IPR007290 Arv1
PANTHERiPTHR14467 PTHR14467, 1 hit
PfamiView protein in Pfam
PF04161 Arv1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D0U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTGGRRGTR SGKGTEGAAA TSSSCLYRCI ECNREAQELY RDYSHGVLKI
60 70 80 90 100
TICKSCQKPV DKYIEYDPVI ILINAILCKT QAYRHILFNT KINIHGKLCM
110 120 130 140 150
FCLLCEAYLR WWQLQDSSQS PAPDDVIRYA KEWDFYRMFV IASFEQAAFL
160 170 180 190 200
TGIFAFLWVQ QPMTAKRAPD FVLLLKALLL SSYGKLLLIP AVIWEHDYTP
210 220 230 240 250
LCLRLIKVFV LTSNFQAVRV TLNTNRRLSL LVVLSGLLLE SIVVFFFQRM
260
EWDVSSDCAL YKSQDF
Length:266
Mass (Da):30,535
Last modified:June 1, 2001 - v1
Checksum:i8A7C7C1078F4BC76
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLE6A0A1D5RLE6_MOUSE
Protein ARV1
Arv1
149Annotation score:
A0A1D5RLR4A0A1D5RLR4_MOUSE
Protein ARV1
Arv1
112Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004398 mRNA Translation: BAB23288.1
AK042561 mRNA Translation: BAC31293.1
CCDSiCCDS22774.1
RefSeqiNP_081131.1, NM_026855.4
XP_006531400.1, XM_006531337.3
XP_006531401.1, XM_006531338.2
XP_011246798.1, XM_011248496.2
UniGeneiMm.22779

Genome annotation databases

EnsembliENSMUST00000034463; ENSMUSP00000034463; ENSMUSG00000031982
GeneIDi68865
KEGGimmu:68865
UCSCiuc009nxn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004398 mRNA Translation: BAB23288.1
AK042561 mRNA Translation: BAC31293.1
CCDSiCCDS22774.1
RefSeqiNP_081131.1, NM_026855.4
XP_006531400.1, XM_006531337.3
XP_006531401.1, XM_006531338.2
XP_011246798.1, XM_011248496.2
UniGeneiMm.22779

3D structure databases

ProteinModelPortaliQ9D0U9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034463

PTM databases

PhosphoSitePlusiQ9D0U9

Proteomic databases

EPDiQ9D0U9
MaxQBiQ9D0U9
PaxDbiQ9D0U9
PRIDEiQ9D0U9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034463; ENSMUSP00000034463; ENSMUSG00000031982
GeneIDi68865
KEGGimmu:68865
UCSCiuc009nxn.1 mouse

Organism-specific databases

CTDi64801
MGIiMGI:1916115 Arv1

Phylogenomic databases

eggNOGiKOG3134 Eukaryota
COG5254 LUCA
GeneTreeiENSGT00390000002675
HOGENOMiHOG000013218
HOVERGENiHBG080869
InParanoidiQ9D0U9
KOiK21848
OMAiYFFQRME
OrthoDBiEOG091G0RKK
PhylomeDBiQ9D0U9
TreeFamiTF105845

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis

Miscellaneous databases

PROiPR:Q9D0U9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031982 Expressed in 149 organ(s), highest expression level in optic fissure
CleanExiMM_ARV1
ExpressionAtlasiQ9D0U9 baseline and differential
GenevisibleiQ9D0U9 MM

Family and domain databases

InterProiView protein in InterPro
IPR007290 Arv1
PANTHERiPTHR14467 PTHR14467, 1 hit
PfamiView protein in Pfam
PF04161 Arv1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARV1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0U9
Secondary accession number(s): Q8BY08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again