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Protein

Histidine triad nucleotide-binding protein 2, mitochondrial

Gene

Hint2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Purine nucleotide phosphoramidateBy similarity1
Binding sitei80Purine nucleotide phosphoramidateBy similarity1
Binding sitei136Purine nucleotide phosphoramidateBy similarity1
Active sitei149Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 145Purine nucleotide phosphoramidateBy similarity4
Nucleotide bindingi149 – 151Purine nucleotide phosphoramidateBy similarity3

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • lipid catabolic process Source: MGI
  • negative regulation of peptidyl-lysine acetylation Source: MGI
  • steroid biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processApoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine triad nucleotide-binding protein 2, mitochondrialCurated (EC:3.-.-.-)
Short name:
HINT-2By similarity
Alternative name(s):
HINT-3By similarity
Gene namesi
Name:Hint2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916167 Hint2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000010978718 – 163Histidine triad nucleotide-binding protein 2, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45N6-succinyllysineCombined sources1
Modified residuei119N6-acetyllysineCombined sources1
Modified residuei128N6-acetyllysine; alternateCombined sources1
Modified residuei128N6-succinyllysine; alternateCombined sources1
Modified residuei139N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D0S9
MaxQBiQ9D0S9
PaxDbiQ9D0S9
PRIDEiQ9D0S9

PTM databases

iPTMnetiQ9D0S9
PhosphoSitePlusiQ9D0S9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028470
CleanExiMM_HINT2
ExpressionAtlasiQ9D0S9 baseline and differential
GenevisibleiQ9D0S9 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D0S9, 3 interactors
MINTiQ9D0S9
STRINGi10090.ENSMUSP00000030192

Structurei

3D structure databases

ProteinModelPortaliQ9D0S9
SMRiQ9D0S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 163HITPROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 151Histidine triad motif5

Sequence similaritiesi

Belongs to the HINT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3275 Eukaryota
COG0537 LUCA
GeneTreeiENSGT00510000046448
HOGENOMiHOG000061064
HOVERGENiHBG051906
InParanoidiQ9D0S9
OMAiNVAKQES
OrthoDBiEOG091G1001
PhylomeDBiQ9D0S9
TreeFamiTF314862

Family and domain databases

Gene3Di3.30.428.10, 1 hit
InterProiView protein in InterPro
IPR019808 Histidine_triad_CS
IPR001310 Histidine_triad_HIT
IPR011146 HIT-like
IPR036265 HIT-like_sf
PANTHERiPTHR23089 PTHR23089, 1 hit
PfamiView protein in Pfam
PF01230 HIT, 1 hit
PRINTSiPR00332 HISTRIAD
SUPFAMiSSF54197 SSF54197, 1 hit
PROSITEiView protein in PROSITE
PS00892 HIT_1, 1 hit
PS51084 HIT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLLAVG LRAARRTLAA AGARGAQVRG NAGVSDGSEV AKAQKAAPGG
60 70 80 90 100
ASPTIFSRIL DRSLPADILY EDQQCLVFRD VAPQAPVHFL VIPRKPIPRI
110 120 130 140 150
SQAEEDDQQL LGHLLLVAKK IAQAQGLKDG YRLVVNDGKM GAQSVYHLHI
160
HVLGGRQLQW PPG
Length:163
Mass (Da):17,320
Last modified:June 1, 2001 - v1
Checksum:i1FD421AF2AD3E448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356874 mRNA Translation: AAM00220.1
AY040765 Genomic DNA Translation: AAK94774.1
AK004497 mRNA Translation: BAB23334.1
CCDSiCCDS18106.1
RefSeqiNP_081147.1, NM_026871.1
UniGeneiMm.25285

Genome annotation databases

EnsembliENSMUST00000030192; ENSMUSP00000030192; ENSMUSG00000028470
GeneIDi68917
KEGGimmu:68917
UCSCiuc008sqs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHINT2_MOUSE
AccessioniPrimary (citable) accession number: Q9D0S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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