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Protein

Neuralized-like protein 2

Gene

Neurl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • myofibril assembly Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • sarcomere organization Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Neuralized-like protein 2
Gene namesi
Name:Neurl2
Synonyms:Ozz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3043305 Neurl2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812581 – 285Neuralized-like protein 2Add BLAST285

Proteomic databases

PaxDbiQ9D0S4
PRIDEiQ9D0S4

Expressioni

Tissue specificityi

Expressed specifically in skeletal and cardiac muscles.1 Publication

Developmental stagei

At 10 dpc, confined to the developing heart and the somites at the tips of the myotomal cells near the intermyotomal septum. At 14 to 15 dpc, accumulates near the myotendinous junctions, the site of sarcomere assembly in growing myotubes. Present in negligible amounts in proliferating myoblasts, induced during differentiation.

Gene expression databases

CleanExiMM_NEURL2

Interactioni

Subunit structurei

Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of ELOB/Elongin B, ELOC/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1.1 Publication

Protein-protein interaction databases

CORUMiQ9D0S4
STRINGi10090.ENSMUSP00000041806

Structurei

3D structure databases

ProteinModelPortaliQ9D0S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 244NHRPROSITE-ProRule annotationAdd BLAST222
Domaini250 – 285SOCS boxPROSITE-ProRule annotationAdd BLAST36

Domaini

The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.By similarity

Phylogenomic databases

eggNOGiENOG410IMDX Eukaryota
ENOG4111F7Q LUCA
HOGENOMiHOG000231005
HOVERGENiHBG052607
InParanoidiQ9D0S4
PhylomeDBiQ9D0S4

Family and domain databases

InterProiView protein in InterPro
IPR037962 Neuralized
IPR006573 NHR_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00588 NEUZ, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
PROSITEiView protein in PROSITE
PS51065 NHR, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPSEHVGL GGPRSPARPE PPPTRFHQVH GANIRMDPSG TRATRVESFA
60 70 80 90 100
HGVCFSREPL APGQVFLVEI EEKELGWCGH LRLGLTALDP ASLAAVPEFS
110 120 130 140 150
LPDLVSLGHS WVFAITRHHN RVPREGQPEA EAAVPSGPQA LLVEPYLRIE
160 170 180 190 200
QFRIPRDRLV GRSRPGLYSH LLDQLYEQNV LPPTARRSRL GVLFCPREDG
210 220 230 240 250
TADMHIIING EDMGPSARGL PAAQPLYAVV DVFASTKSVR LVQLEYGLPS
260 270 280
LQTLCRLVIH KRVVHRLAID VLHLPKGLKD FCKYE
Length:285
Mass (Da):31,537
Last modified:June 1, 2001 - v1
Checksum:i4A0B7CFEF27B10B8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5J5A2A5J5_MOUSE
Neuralized-like protein 2
Neurl2
285Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004524 mRNA Translation: BAB23346.1
CCDSiCCDS38330.1
UniGeneiMm.474586

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004524 mRNA Translation: BAB23346.1
CCDSiCCDS38330.1
UniGeneiMm.474586

3D structure databases

ProteinModelPortaliQ9D0S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9D0S4
STRINGi10090.ENSMUSP00000041806

Proteomic databases

PaxDbiQ9D0S4
PRIDEiQ9D0S4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:3043305 Neurl2

Phylogenomic databases

eggNOGiENOG410IMDX Eukaryota
ENOG4111F7Q LUCA
HOGENOMiHOG000231005
HOVERGENiHBG052607
InParanoidiQ9D0S4
PhylomeDBiQ9D0S4

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiJag1 mouse
PROiPR:Q9D0S4
SOURCEiSearch...

Gene expression databases

CleanExiMM_NEURL2

Family and domain databases

InterProiView protein in InterPro
IPR037962 Neuralized
IPR006573 NHR_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00588 NEUZ, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
PROSITEiView protein in PROSITE
PS51065 NHR, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUL2_MOUSE
AccessioniPrimary (citable) accession number: Q9D0S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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