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Protein

Probable ATP-dependent RNA helicase DDX56

Gene

Ddx56

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX56 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent 61 kDa nucleolar RNA helicase
DEAD box protein 56
Gene namesi
Name:Ddx56
Synonyms:D11Ertd619e, Noh61
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277172 Ddx56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550591 – 546Probable ATP-dependent RNA helicase DDX56Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei141PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0R4
MaxQBiQ9D0R4
PaxDbiQ9D0R4
PRIDEiQ9D0R4

PTM databases

iPTMnetiQ9D0R4
PhosphoSitePlusiQ9D0R4

Expressioni

Gene expression databases

BgeeiENSMUSG00000004393 Expressed in 266 organ(s), highest expression level in ear
CleanExiMM_DDX56
ExpressionAtlasiQ9D0R4 baseline and differential
GenevisibleiQ9D0R4 MM

Interactioni

Subunit structurei

May form homooligomeric complexes.

Protein-protein interaction databases

BioGridi206632, 3 interactors
CORUMiQ9D0R4
IntActiQ9D0R4, 1 interactor
STRINGi10090.ENSMUSP00000004507

Structurei

3D structure databases

ProteinModelPortaliQ9D0R4
SMRiQ9D0R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 218Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST181
Domaini230 – 424Helicase C-terminalPROSITE-ProRule annotationAdd BLAST195

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 35Q motifAdd BLAST29
Motifi166 – 169DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0346 Eukaryota
ENOG410XR15 LUCA
GeneTreeiENSGT00550000074946
HOGENOMiHOG000253015
HOVERGENiHBG051334
InParanoidiQ9D0R4
KOiK14810
OMAiRYRMEDA
OrthoDBiEOG091G04UR
PhylomeDBiQ9D0R4
TreeFamiTF300620

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDQEALGFE HMGLDPRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR
60 70 80 90 100
ARTGSGKTAA YAIPMLQSLL HKKATGPVME QAVRGLVLVP TKELARQAQA
110 120 130 140 150
MIQQLAAYCA RDVRVANVSA AEDSASQRAV LMEKPDVVVG TPSRVLSHLQ
160 170 180 190 200
QNTLKLRDSL ELLVVDEADL LFSFGFEDEL KSLLCHLPRI YQAFLMSATF
210 220 230 240 250
NEDVQTLKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET EEDKFLLLYA
260 270 280 290 300
LLKLSLIRGK ALLFVNTLER GYRLRLFLEQ FSIPSCVLNG ELPLRSRCHI
310 320 330 340 350
ISQFNQGLYD CVIATDAEIL GPQVKGKRRG RGSKGNKASD PESGVARGID
360 370 380 390 400
FHHVSAVLNF DLPPTAEAYV HRAGRTARAN NPGIVLTFVL PAEQPFLGKI
410 420 430 440 450
EDLLSGEGEA PILLPYQFQM EEIESFRYRC RDAMRSVTKQ AIREARLKEI
460 470 480 490 500
KEELLHSEKL KTYFEDNPRD LQLLRHDLPL HPAVVKPHLG HVPDYLVPAA
510 520 530 540
LRGLVHPRKK RRKVPFSRKA KKVKAQNPLR DFKHRGKKPK PAAKPS
Length:546
Mass (Da):61,212
Last modified:June 1, 2001 - v1
Checksum:i3C19F7354C29F9A1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVX2Q5SVX2_MOUSE
Probable ATP-dependent RNA helicase...
Ddx56
237Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011136 mRNA Translation: BAB27426.1
AK077514 mRNA Translation: BAC36839.1
BC018291 mRNA Translation: AAH18291.1
CCDSiCCDS24414.1
RefSeqiNP_080814.1, NM_026538.3
UniGeneiMm.29810

Genome annotation databases

EnsembliENSMUST00000004507; ENSMUSP00000004507; ENSMUSG00000004393
GeneIDi52513
KEGGimmu:52513
UCSCiuc007hyc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011136 mRNA Translation: BAB27426.1
AK077514 mRNA Translation: BAC36839.1
BC018291 mRNA Translation: AAH18291.1
CCDSiCCDS24414.1
RefSeqiNP_080814.1, NM_026538.3
UniGeneiMm.29810

3D structure databases

ProteinModelPortaliQ9D0R4
SMRiQ9D0R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206632, 3 interactors
CORUMiQ9D0R4
IntActiQ9D0R4, 1 interactor
STRINGi10090.ENSMUSP00000004507

PTM databases

iPTMnetiQ9D0R4
PhosphoSitePlusiQ9D0R4

Proteomic databases

EPDiQ9D0R4
MaxQBiQ9D0R4
PaxDbiQ9D0R4
PRIDEiQ9D0R4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004507; ENSMUSP00000004507; ENSMUSG00000004393
GeneIDi52513
KEGGimmu:52513
UCSCiuc007hyc.1 mouse

Organism-specific databases

CTDi54606
MGIiMGI:1277172 Ddx56

Phylogenomic databases

eggNOGiKOG0346 Eukaryota
ENOG410XR15 LUCA
GeneTreeiENSGT00550000074946
HOGENOMiHOG000253015
HOVERGENiHBG051334
InParanoidiQ9D0R4
KOiK14810
OMAiRYRMEDA
OrthoDBiEOG091G04UR
PhylomeDBiQ9D0R4
TreeFamiTF300620

Miscellaneous databases

ChiTaRSiDdx56 mouse
PROiPR:Q9D0R4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004393 Expressed in 266 organ(s), highest expression level in ear
CleanExiMM_DDX56
ExpressionAtlasiQ9D0R4 baseline and differential
GenevisibleiQ9D0R4 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDX56_MOUSE
AccessioniPrimary (citable) accession number: Q9D0R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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