UniProtKB - Q9D0R4 (DDX56_MOUSE)
Protein
Probable ATP-dependent RNA helicase DDX56
Gene
Ddx56
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity).By similarity
Catalytic activityi
- EC:3.6.4.13
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 51 – 58 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- positive regulation of neuron projection development Source: MGI
- rRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | Ribosome biogenesis, rRNA processing |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-dependent RNA helicase DDX56 (EC:3.6.4.13)Alternative name(s): ATP-dependent 61 kDa nucleolar RNA helicase DEAD box protein 56 |
Gene namesi | Name:Ddx56 Synonyms:D11Ertd619e, Noh61 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1277172, Ddx56 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055059 | 1 – 546 | Probable ATP-dependent RNA helicase DDX56Add BLAST | 546 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 126 | PhosphoserineBy similarity | 1 | |
Modified residuei | 141 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9D0R4 |
MaxQBi | Q9D0R4 |
PaxDbi | Q9D0R4 |
PRIDEi | Q9D0R4 |
PTM databases
iPTMneti | Q9D0R4 |
PhosphoSitePlusi | Q9D0R4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004393, Expressed in ear and 283 other tissues |
ExpressionAtlasi | Q9D0R4, baseline and differential |
Genevisiblei | Q9D0R4, MM |
Interactioni
Subunit structurei
May form homooligomeric complexes.
Protein-protein interaction databases
BioGRIDi | 206632, 4 interactors |
CORUMi | Q9D0R4 |
IntActi | Q9D0R4, 1 interactor |
STRINGi | 10090.ENSMUSP00000004507 |
Miscellaneous databases
RNActi | Q9D0R4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 218 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 181 | |
Domaini | 230 – 424 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 195 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 35 | Q motifAdd BLAST | 29 | |
Motifi | 166 – 169 | DEAD box | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0346, Eukaryota |
GeneTreei | ENSGT00550000074946 |
HOGENOMi | CLU_003041_17_1_1 |
InParanoidi | Q9D0R4 |
OMAi | RYRAQDC |
OrthoDBi | 973872at2759 |
PhylomeDBi | Q9D0R4 |
TreeFami | TF300620 |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9D0R4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDQEALGFE HMGLDPRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR
60 70 80 90 100
ARTGSGKTAA YAIPMLQSLL HKKATGPVME QAVRGLVLVP TKELARQAQA
110 120 130 140 150
MIQQLAAYCA RDVRVANVSA AEDSASQRAV LMEKPDVVVG TPSRVLSHLQ
160 170 180 190 200
QNTLKLRDSL ELLVVDEADL LFSFGFEDEL KSLLCHLPRI YQAFLMSATF
210 220 230 240 250
NEDVQTLKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET EEDKFLLLYA
260 270 280 290 300
LLKLSLIRGK ALLFVNTLER GYRLRLFLEQ FSIPSCVLNG ELPLRSRCHI
310 320 330 340 350
ISQFNQGLYD CVIATDAEIL GPQVKGKRRG RGSKGNKASD PESGVARGID
360 370 380 390 400
FHHVSAVLNF DLPPTAEAYV HRAGRTARAN NPGIVLTFVL PAEQPFLGKI
410 420 430 440 450
EDLLSGEGEA PILLPYQFQM EEIESFRYRC RDAMRSVTKQ AIREARLKEI
460 470 480 490 500
KEELLHSEKL KTYFEDNPRD LQLLRHDLPL HPAVVKPHLG HVPDYLVPAA
510 520 530 540
LRGLVHPRKK RRKVPFSRKA KKVKAQNPLR DFKHRGKKPK PAAKPS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5SVX2 | Q5SVX2_MOUSE | RNA helicase | Ddx56 | 237 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011136 mRNA Translation: BAB27426.1 AK077514 mRNA Translation: BAC36839.1 BC018291 mRNA Translation: AAH18291.1 |
CCDSi | CCDS24414.1 |
RefSeqi | NP_080814.1, NM_026538.3 |
Genome annotation databases
Ensembli | ENSMUST00000004507; ENSMUSP00000004507; ENSMUSG00000004393 |
GeneIDi | 52513 |
KEGGi | mmu:52513 |
UCSCi | uc007hyc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011136 mRNA Translation: BAB27426.1 AK077514 mRNA Translation: BAC36839.1 BC018291 mRNA Translation: AAH18291.1 |
CCDSi | CCDS24414.1 |
RefSeqi | NP_080814.1, NM_026538.3 |
3D structure databases
SMRi | Q9D0R4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206632, 4 interactors |
CORUMi | Q9D0R4 |
IntActi | Q9D0R4, 1 interactor |
STRINGi | 10090.ENSMUSP00000004507 |
PTM databases
iPTMneti | Q9D0R4 |
PhosphoSitePlusi | Q9D0R4 |
Proteomic databases
EPDi | Q9D0R4 |
MaxQBi | Q9D0R4 |
PaxDbi | Q9D0R4 |
PRIDEi | Q9D0R4 |
Protocols and materials databases
Antibodypediai | 13419, 326 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000004507; ENSMUSP00000004507; ENSMUSG00000004393 |
GeneIDi | 52513 |
KEGGi | mmu:52513 |
UCSCi | uc007hyc.1, mouse |
Organism-specific databases
CTDi | 54606 |
MGIi | MGI:1277172, Ddx56 |
Phylogenomic databases
eggNOGi | KOG0346, Eukaryota |
GeneTreei | ENSGT00550000074946 |
HOGENOMi | CLU_003041_17_1_1 |
InParanoidi | Q9D0R4 |
OMAi | RYRAQDC |
OrthoDBi | 973872at2759 |
PhylomeDBi | Q9D0R4 |
TreeFami | TF300620 |
Miscellaneous databases
BioGRID-ORCSi | 52513, 8 hits in 17 CRISPR screens |
ChiTaRSi | Ddx56, mouse |
PROi | PR:Q9D0R4 |
RNActi | Q9D0R4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004393, Expressed in ear and 283 other tissues |
ExpressionAtlasi | Q9D0R4, baseline and differential |
Genevisiblei | Q9D0R4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDX56_MOUSE | |
Accessioni | Q9D0R4Primary (citable) accession number: Q9D0R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families