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Entry version 150 (16 Oct 2019)
Sequence version 2 (01 Mar 2003)
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Protein

Threonine--tRNA ligase 1, cytoplasmic

Gene

Tars1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.74 µM for tRNA(Thr)1 Publication
  2. KM=0.30 mM for L-threonine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Nucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Threonine--tRNA ligase 1, cytoplasmic (EC:6.1.1.31 Publication)
    Alternative name(s):
    Threonine--tRNA ligase, cytoplasmic
    Threonyl-tRNA synthetase
    Short name:
    ThrRS
    Threonyl-tRNA synthetase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Tars1
    Synonyms:TarsImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:106314 Tars

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi154H → A: Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-158. 1 Publication1
    Mutagenesisi158H → A: Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-154. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3751649

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001011201 – 722Threonine--tRNA ligase 1, cytoplasmicAdd BLAST722

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei242N6-acetyllysineCombined sources1
    Modified residuei245PhosphothreonineBy similarity1
    Modified residuei297PhosphotyrosineCombined sources1
    Modified residuei452PhosphothreonineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    ISGylated.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9D0R2

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9D0R2

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9D0R2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9D0R2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9D0R2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9D0R2

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9D0R2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9D0R2

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9D0R2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000022241 Expressed in 307 organ(s), highest expression level in primitive streak

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9D0R2 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9D0R2 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    226055, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9D0R2, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    Q9D0R2

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000022849

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9D0R2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 142TGSPROSITE-ProRule annotationAdd BLAST65

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1637 Eukaryota
    COG0441 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154969

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000003878

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9D0R2

    KEGG Orthology (KO)

    More...
    KOi
    K01868

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FYYDFAY

    Database of Orthologous Groups

    More...
    OrthoDBi
    813937at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9D0R2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300858

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00771 ThrRS_core, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.10.20.30, 1 hit
    3.40.50.800, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00184 Thr_tRNA_synth, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002314 aa-tRNA-synt_IIb
    IPR006195 aa-tRNA-synth_II
    IPR004154 Anticodon-bd
    IPR036621 Anticodon-bd_dom_sf
    IPR012675 Beta-grasp_dom_sf
    IPR004095 TGS
    IPR012676 TGS-like
    IPR002320 Thr-tRNA-ligase_IIa
    IPR018163 Thr/Ala-tRNA-synth_IIc_edit
    IPR033728 ThrRS_core
    IPR012947 tRNA_SAD

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11451 PTHR11451, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03129 HGTP_anticodon, 1 hit
    PF02824 TGS, 1 hit
    PF00587 tRNA-synt_2b, 1 hit
    PF07973 tRNA_SAD, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01047 TRNASYNTHTHR

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00863 tRNA_SAD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55186 SSF55186, 1 hit
    SSF81271 SSF81271, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00418 thrS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50862 AA_TRNA_LIGASE_II, 1 hit
    PS51880 TGS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9D0R2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSQEKASSPS GKMDGEKPVD ASEEKRKEGG KKKSKDGGGD GGRAELNPWP
    60 70 80 90 100
    EYINTRLDMY NKLKAEHDSI LAEKAAKDSK PIKVTLPDGK QVDAESWKTT
    110 120 130 140 150
    PYQIACGISQ GLADNTVVAK VNKVVWDLDR PLETDCTLEL LKFEDEEAQA
    160 170 180 190 200
    VYWHSSAHIM GEAMERVYGG CLCYGPPIEN GFYYDMYLEE GGVSSNDFSS
    210 220 230 240 250
    LETLCKKIIK EKQTFERLEV KKETLLEMFK YNKFKCRILN EKVNTPTTTV
    260 270 280 290 300
    YRCGPLIDLC RGPHVRHTGK IKTLKIHKNS STYWEGKADM ETLQRIYGIS
    310 320 330 340 350
    FPDPKLLKEW EKFQEEAKNR DHRKIGRDQE LYFFHELSPG SCFFLPKGAY
    360 370 380 390 400
    IYNTLMEFIR SEYRKRGFQE VVTPNIFNSR LWMTSGHWQH YSENMFSFEV
    410 420 430 440 450
    EKEQFALKPM NCPGHCLMFD HRPRSWRELP LRLADFGVLH RNELSGALTG
    460 470 480 490 500
    LTRVRRFQQD DAHIFCAMEQ IEDEIKGCLD FLRTVYSVFG FSFKLNLSTR
    510 520 530 540 550
    PEKFLGDIEI WNQAEKQLEN SLNEFGEKWE LNPGDGAFYG PKIDIQIKDA
    560 570 580 590 600
    IGRYHQCATI QLDFQLPIRF NLTYVSHDGD DKKRPVIVHR AILGSVERMI
    610 620 630 640 650
    AILTENYGGK WPFWLSPRQV MVVPVGPTCD EYAQKVRQQF HDAKFMADTD
    660 670 680 690 700
    LDPGCTLNKK IRNAQLAQYN FILVVGEKEK ASGTVNIRTR DNKVHGERTV
    710 720
    EETVRRLQQL KQTRSKQAEE EF
    Length:722
    Mass (Da):83,356
    Last modified:March 1, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFBA7DC409BFD0B1
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2I3BPK8A0A2I3BPK8_MOUSE
    Threonine--tRNA ligase, cytoplasmic
    Tars
    119Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176P → S in BAB26799 (PubMed:16141072).Curated1
    Sequence conflicti271I → T in BAB26799 (PubMed:16141072).Curated1
    Sequence conflicti322H → Y in AAH55371 (PubMed:15489334).Curated1
    Sequence conflicti323R → G in BAB26799 (PubMed:16141072).Curated1
    Sequence conflicti325I → T in AAH55371 (PubMed:15489334).Curated1
    Sequence conflicti563D → Y in BAC27235 (PubMed:16141072).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK010256 mRNA Translation: BAB26799.1
    AK011146 mRNA Translation: BAB27429.2
    AK031064 mRNA Translation: BAC27235.1
    AK152945 mRNA Translation: BAE31616.1
    AK166693 mRNA Translation: BAE38950.1
    AK167597 mRNA Translation: BAE39654.1
    AK168969 mRNA Translation: BAE40773.1
    BC055371 mRNA Translation: AAH55371.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS27385.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_149065.2, NM_033074.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000022849; ENSMUSP00000022849; ENSMUSG00000022241

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    110960

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:110960

    UCSC genome browser

    More...
    UCSCi
    uc007vhc.1 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK010256 mRNA Translation: BAB26799.1
    AK011146 mRNA Translation: BAB27429.2
    AK031064 mRNA Translation: BAC27235.1
    AK152945 mRNA Translation: BAE31616.1
    AK166693 mRNA Translation: BAE38950.1
    AK167597 mRNA Translation: BAE39654.1
    AK168969 mRNA Translation: BAE40773.1
    BC055371 mRNA Translation: AAH55371.1
    CCDSiCCDS27385.1
    RefSeqiNP_149065.2, NM_033074.3

    3D structure databases

    SMRiQ9D0R2
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi226055, 2 interactors
    IntActiQ9D0R2, 1 interactor
    MINTiQ9D0R2
    STRINGi10090.ENSMUSP00000022849

    Chemistry databases

    ChEMBLiCHEMBL3751649

    PTM databases

    iPTMnetiQ9D0R2
    PhosphoSitePlusiQ9D0R2
    SwissPalmiQ9D0R2

    Proteomic databases

    EPDiQ9D0R2
    jPOSTiQ9D0R2
    MaxQBiQ9D0R2
    PaxDbiQ9D0R2
    PeptideAtlasiQ9D0R2
    PRIDEiQ9D0R2

    Genome annotation databases

    EnsembliENSMUST00000022849; ENSMUSP00000022849; ENSMUSG00000022241
    GeneIDi110960
    KEGGimmu:110960
    UCSCiuc007vhc.1 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6897
    MGIiMGI:106314 Tars

    Phylogenomic databases

    eggNOGiKOG1637 Eukaryota
    COG0441 LUCA
    GeneTreeiENSGT00940000154969
    HOGENOMiHOG000003878
    InParanoidiQ9D0R2
    KOiK01868
    OMAiFYYDFAY
    OrthoDBi813937at2759
    PhylomeDBiQ9D0R2
    TreeFamiTF300858

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Tars mouse

    Protein Ontology

    More...
    PROi
    PR:Q9D0R2

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000022241 Expressed in 307 organ(s), highest expression level in primitive streak
    ExpressionAtlasiQ9D0R2 baseline and differential
    GenevisibleiQ9D0R2 MM

    Family and domain databases

    CDDicd00771 ThrRS_core, 1 hit
    Gene3Di3.10.20.30, 1 hit
    3.40.50.800, 1 hit
    HAMAPiMF_00184 Thr_tRNA_synth, 1 hit
    InterProiView protein in InterPro
    IPR002314 aa-tRNA-synt_IIb
    IPR006195 aa-tRNA-synth_II
    IPR004154 Anticodon-bd
    IPR036621 Anticodon-bd_dom_sf
    IPR012675 Beta-grasp_dom_sf
    IPR004095 TGS
    IPR012676 TGS-like
    IPR002320 Thr-tRNA-ligase_IIa
    IPR018163 Thr/Ala-tRNA-synth_IIc_edit
    IPR033728 ThrRS_core
    IPR012947 tRNA_SAD
    PANTHERiPTHR11451 PTHR11451, 1 hit
    PfamiView protein in Pfam
    PF03129 HGTP_anticodon, 1 hit
    PF02824 TGS, 1 hit
    PF00587 tRNA-synt_2b, 1 hit
    PF07973 tRNA_SAD, 1 hit
    PRINTSiPR01047 TRNASYNTHTHR
    SMARTiView protein in SMART
    SM00863 tRNA_SAD, 1 hit
    SUPFAMiSSF55186 SSF55186, 1 hit
    SSF81271 SSF81271, 1 hit
    TIGRFAMsiTIGR00418 thrS, 1 hit
    PROSITEiView protein in PROSITE
    PS50862 AA_TRNA_LIGASE_II, 1 hit
    PS51880 TGS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTC_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D0R2
    Secondary accession number(s): Q3TL42
    , Q7TMQ2, Q8BMI6, Q9CX03
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2003
    Last modified: October 16, 2019
    This is version 150 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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