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Protein

Proline/serine-rich coiled-coil protein 1

Gene

Psrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity).By similarity

GO - Molecular functioni

  • microtubule binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Proline/serine-rich coiled-coil protein 1
Gene namesi
Name:Psrc1
Synonyms:Dda3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913099 Psrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002737291 – 329Proline/serine-rich coiled-coil protein 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0P7
MaxQBiQ9D0P7
PaxDbiQ9D0P7
PeptideAtlasiQ9D0P7
PRIDEiQ9D0P7

PTM databases

iPTMnetiQ9D0P7
PhosphoSitePlusiQ9D0P7

Expressioni

Tissue specificityi

Highly expressed in heart, brain and lung. Weaker expression in kidney and testis.1 Publication

Inductioni

Induced by adriamycin and mitomycin C, in a p53-dependent manner, in NIH3T3 cells. This induction is inhibited by actinomycin D. Also induced by cisplatin in a p73-dependent manner in embryonic cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000068744 Expressed in 211 organ(s), highest expression level in embryonic stem cell
CleanExiMM_PSRC1
ExpressionAtlasiQ9D0P7 baseline and differential
GenevisibleiQ9D0P7 MM

Interactioni

Subunit structurei

Interacts with APC2 (PubMed:17310996). Interacts with KIF2A (By similarity). Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208155, 2 interactors
IntActiQ9D0P7, 1 interactor
STRINGi10090.ENSMUSP00000088049

Structurei

3D structure databases

ProteinModelPortaliQ9D0P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 4114
Repeati68 – 7124
Repeati103 – 10634
Repeati194 – 19744
Repeati212 – 21554

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 2155 X 4 AA repeats of P-X-X-PAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 94Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 327Pro/Ser-richAdd BLAST117

Sequence similaritiesi

Belongs to the PSRC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEJI Eukaryota
ENOG410Z01V LUCA
GeneTreeiENSGT00510000048604
HOGENOMiHOG000231348
HOVERGENiHBG080237
InParanoidiQ9D0P7
KOiK21443
OMAiQCALQER
OrthoDBiEOG091G12JI
PhylomeDBiQ9D0P7
TreeFamiTF338374

Family and domain databases

InterProiView protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDLKEDIKF IVDETLDFGG LSPSDSHEEE DITVLVSPEK PLRRGLAHRS
60 70 80 90 100
NPNEVAPALQ GVRFSLGPLS PEKLEEILDE ANRLAAQLEE CALKDRERAG
110 120 130 140 150
TGPGRPSPRG KPSPRRETFV LKDSPVRDLL PTVSSWSTPP PSSLAGLRSS
160 170 180 190 200
DKKGSARAVR VASGKKPSSI KKESPTCNLF PASKSPGRSP LAQPILPPRR
210 220 230 240 250
KTGFGARTTA SPPIPVRPVP QSSASNSQCS SRLQGAAVKS SSRLPVPSAI
260 270 280 290 300
PKPATRVPLI GRSLPPGKGA LAPDSLSTQK GHPSAIGHRA SVSQKTNLPT
310 320
TSAARGRTTS AARGRAQPLR KAAVPGPTR
Length:329
Mass (Da):34,707
Last modified:January 23, 2007 - v2
Checksum:iA269CBC53ACC3D31
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AEF3A2AEF3_MOUSE
Proline/serine-rich coiled-coil pro...
Psrc1
172Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188R → G in BAB27461 (PubMed:15489334).Curated1
Sequence conflicti217R → S in BAB27461 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156598 mRNA Translation: AAF24174.1
AF322890 Genomic DNA Translation: AAN73433.1
AK017302 mRNA Translation: BAB30682.1
AK011197 mRNA Translation: BAB27461.1
AK041835 mRNA Translation: BAC31079.1
AK167415 mRNA Translation: BAE39503.1
BC019165 mRNA Translation: AAH19165.1
AF284692 Genomic DNA Translation: AAM45430.1
CCDSiCCDS17758.1
RefSeqiNP_001177090.1, NM_001190161.1
NP_064360.1, NM_019976.3
UniGeneiMm.389499

Genome annotation databases

EnsembliENSMUST00000090561; ENSMUSP00000088049; ENSMUSG00000068744
ENSMUST00000102629; ENSMUSP00000099689; ENSMUSG00000068744
GeneIDi56742
KEGGimmu:56742
UCSCiuc008qyv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156598 mRNA Translation: AAF24174.1
AF322890 Genomic DNA Translation: AAN73433.1
AK017302 mRNA Translation: BAB30682.1
AK011197 mRNA Translation: BAB27461.1
AK041835 mRNA Translation: BAC31079.1
AK167415 mRNA Translation: BAE39503.1
BC019165 mRNA Translation: AAH19165.1
AF284692 Genomic DNA Translation: AAM45430.1
CCDSiCCDS17758.1
RefSeqiNP_001177090.1, NM_001190161.1
NP_064360.1, NM_019976.3
UniGeneiMm.389499

3D structure databases

ProteinModelPortaliQ9D0P7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208155, 2 interactors
IntActiQ9D0P7, 1 interactor
STRINGi10090.ENSMUSP00000088049

PTM databases

iPTMnetiQ9D0P7
PhosphoSitePlusiQ9D0P7

Proteomic databases

EPDiQ9D0P7
MaxQBiQ9D0P7
PaxDbiQ9D0P7
PeptideAtlasiQ9D0P7
PRIDEiQ9D0P7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090561; ENSMUSP00000088049; ENSMUSG00000068744
ENSMUST00000102629; ENSMUSP00000099689; ENSMUSG00000068744
GeneIDi56742
KEGGimmu:56742
UCSCiuc008qyv.2 mouse

Organism-specific databases

CTDi84722
MGIiMGI:1913099 Psrc1

Phylogenomic databases

eggNOGiENOG410IEJI Eukaryota
ENOG410Z01V LUCA
GeneTreeiENSGT00510000048604
HOGENOMiHOG000231348
HOVERGENiHBG080237
InParanoidiQ9D0P7
KOiK21443
OMAiQCALQER
OrthoDBiEOG091G12JI
PhylomeDBiQ9D0P7
TreeFamiTF338374

Miscellaneous databases

ChiTaRSiPsrc1 mouse
PROiPR:Q9D0P7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068744 Expressed in 211 organ(s), highest expression level in embryonic stem cell
CleanExiMM_PSRC1
ExpressionAtlasiQ9D0P7 baseline and differential
GenevisibleiQ9D0P7 MM

Family and domain databases

InterProiView protein in InterPro
IPR026658 DDA3
IPR026657 DDA3/GTSE-1
IPR032768 GTSE1_N
PANTHERiPTHR21584 PTHR21584, 1 hit
PTHR21584:SF1 PTHR21584:SF1, 1 hit
PfamiView protein in Pfam
PF15259 GTSE1_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSRC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0P7
Secondary accession number(s): Q8K4L8, Q9QXY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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