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Protein

Dynein light chain 2, cytoplasmic

Gene

Dynll2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-139910 Activation of BMF and translocation to mitochondria
R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-1632852 Macroautophagy
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5620924 Intraflagellar transport
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain b
Short name:
DLC8
Short name:
DLC8b
Dynein light chain LC8-type 2
Gene namesi
Name:Dynll2
Synonyms:Dlc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915347 Dynll2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951331 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

EPDiQ9D0M5
MaxQBiQ9D0M5
PaxDbiQ9D0M5
PeptideAtlasiQ9D0M5
PRIDEiQ9D0M5
TopDownProteomicsiQ9D0M5

2D gel databases

REPRODUCTION-2DPAGEiQ9D0M5

PTM databases

iPTMnetiQ9D0M5
PhosphoSitePlusiQ9D0M5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020483 Expressed in 305 organ(s), highest expression level in cerebellum
CleanExiMM_DYNLL2
ExpressionAtlasiQ9D0M5 baseline and differential
GenevisibleiQ9D0M5 MM

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer (PubMed:11546872). Interacts with DYNC1I1 (PubMed:11148209). Interacts with BMF (PubMed:11546872). Component of the myosin V motor complex (PubMed:11546872). Interacts with BCAS1 (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complex1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212654, 1 interactor
IntActiQ9D0M5, 5 interactors
MINTiQ9D0M5
STRINGi10090.ENSMUSP00000020775

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9D0M5
SMRiQ9D0M5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0M5

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOVERGENiHBG002133
InParanoidiQ9D0M5
KOiK10418
OMAiQYIKKEF
OrthoDBiEOG091G15JY
PhylomeDBiQ9D0M5
TreeFamiTF300264

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR019763 Dynein_light_1/2_CS
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239 DYNEIN_LIGHT_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:June 1, 2001 - v1
Checksum:i45364D32C0077F8E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIN4D6RIN4_MOUSE
Dynein light chain
Dynll2
53Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029255 mRNA Translation: AAK38749.1
AK011284 mRNA Translation: BAB27516.1
AK028319 mRNA Translation: BAC25877.1
AK049645 mRNA Translation: BAC33856.1
AK078434 mRNA Translation: BAC37271.1
AK160114 mRNA Translation: BAE35638.1
AK169212 mRNA Translation: BAE40984.1
AL606805 Genomic DNA No translation available.
BC011289 mRNA Translation: AAH11289.1
BC040822 mRNA Translation: AAH40822.1
CCDSiCCDS36272.1
RefSeqiNP_001161943.1, NM_001168471.1
NP_001161944.1, NM_001168472.1
NP_080832.1, NM_026556.4
UniGeneiMm.246436

Genome annotation databases

EnsembliENSMUST00000020775; ENSMUSP00000020775; ENSMUSG00000020483
ENSMUST00000107923; ENSMUSP00000103556; ENSMUSG00000020483
ENSMUST00000178105; ENSMUSP00000136241; ENSMUSG00000020483
GeneIDi68097
KEGGimmu:68097
UCSCiuc007kva.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029255 mRNA Translation: AAK38749.1
AK011284 mRNA Translation: BAB27516.1
AK028319 mRNA Translation: BAC25877.1
AK049645 mRNA Translation: BAC33856.1
AK078434 mRNA Translation: BAC37271.1
AK160114 mRNA Translation: BAE35638.1
AK169212 mRNA Translation: BAE40984.1
AL606805 Genomic DNA No translation available.
BC011289 mRNA Translation: AAH11289.1
BC040822 mRNA Translation: AAH40822.1
CCDSiCCDS36272.1
RefSeqiNP_001161943.1, NM_001168471.1
NP_001161944.1, NM_001168472.1
NP_080832.1, NM_026556.4
UniGeneiMm.246436

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RE6NMR-A/B1-89[»]
ProteinModelPortaliQ9D0M5
SMRiQ9D0M5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212654, 1 interactor
IntActiQ9D0M5, 5 interactors
MINTiQ9D0M5
STRINGi10090.ENSMUSP00000020775

PTM databases

iPTMnetiQ9D0M5
PhosphoSitePlusiQ9D0M5

2D gel databases

REPRODUCTION-2DPAGEiQ9D0M5

Proteomic databases

EPDiQ9D0M5
MaxQBiQ9D0M5
PaxDbiQ9D0M5
PeptideAtlasiQ9D0M5
PRIDEiQ9D0M5
TopDownProteomicsiQ9D0M5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020775; ENSMUSP00000020775; ENSMUSG00000020483
ENSMUST00000107923; ENSMUSP00000103556; ENSMUSG00000020483
ENSMUST00000178105; ENSMUSP00000136241; ENSMUSG00000020483
GeneIDi68097
KEGGimmu:68097
UCSCiuc007kva.2 mouse

Organism-specific databases

CTDi140735
MGIiMGI:1915347 Dynll2

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOVERGENiHBG002133
InParanoidiQ9D0M5
KOiK10418
OMAiQYIKKEF
OrthoDBiEOG091G15JY
PhylomeDBiQ9D0M5
TreeFamiTF300264

Enzyme and pathway databases

ReactomeiR-MMU-139910 Activation of BMF and translocation to mitochondria
R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-1632852 Macroautophagy
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5620924 Intraflagellar transport
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiDynll2 mouse
EvolutionaryTraceiQ9D0M5
PROiPR:Q9D0M5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020483 Expressed in 305 organ(s), highest expression level in cerebellum
CleanExiMM_DYNLL2
ExpressionAtlasiQ9D0M5 baseline and differential
GenevisibleiQ9D0M5 MM

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR019763 Dynein_light_1/2_CS
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239 DYNEIN_LIGHT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYL2_MOUSE
AccessioniPrimary (citable) accession number: Q9D0M5
Secondary accession number(s): A7M7R8, Q3TFB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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