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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

Cyc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Heme (covalent)1
Binding sitei124Heme (covalent)1
Metal bindingi125Iron (heme axial ligand)1
Metal bindingi244Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:Cyc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913695 Cyc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 306Helical; Note=Anchors to the membraneSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 84MitochondrionBy similarityAdd BLAST84
ChainiPRO_000000655585 – 325Cytochrome c1, heme protein, mitochondrialAdd BLAST241

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiQ9D0M3
PeptideAtlasiQ9D0M3
PRIDEiQ9D0M3
TopDownProteomicsiQ9D0M3-1 [Q9D0M3-1]

PTM databases

iPTMnetiQ9D0M3
PhosphoSitePlusiQ9D0M3
SwissPalmiQ9D0M3

Expressioni

Gene expression databases

BgeeiENSMUSG00000022551 Expressed in 297 organ(s), highest expression level in diaphragm
CleanExiMM_CYC1
GenevisibleiQ9D0M3 MM

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

BioGridi211479, 2 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9D0M3
IntActiQ9D0M3, 18 interactors
MINTiQ9D0M3
STRINGi10090.ENSMUSP00000023210

Structurei

3D structure databases

ProteinModelPortaliQ9D0M3
SMRiQ9D0M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 209Cytochrome cPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3052 Eukaryota
COG2857 LUCA
GeneTreeiENSGT00390000012445
HOGENOMiHOG000003867
HOVERGENiHBG001239
InParanoidiQ9D0M3
KOiK00413
OMAiSRKIAYR
OrthoDBiEOG091G0FT2
PhylomeDBiQ9D0M3
TreeFamiTF314799

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002326 Cyt_c1
IPR021157 Cyt_c1_TM_anchor_C
PANTHERiPTHR10266 PTHR10266, 1 hit
PfamiView protein in Pfam
PF02167 Cytochrom_C1, 1 hit
PRINTSiPR00603 CYTOCHROMEC1
SUPFAMiSSF46626 SSF46626, 1 hit
SSF81496 SSF81496, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D0M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAASLRR TVLGPRGVGL PGASAPGLLG GARSRQLPLR TPQAVSLSSK
60 70 80 90 100
SGPSRGRKVM LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG
110 120 130 140 150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEEEAKALAE
160 170 180 190 200
EVEVQDGPND DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI
210 220 230 240 250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYT
260 270 280 290 300
EVLEYDDGTP ATMSQVAKDV ATFLRWASEP EHDHRKRMGL KMLLMMGLLL
310 320
PLTYAMKRHK WSVLKSRKLA YRPPK
Length:325
Mass (Da):35,328
Last modified:June 1, 2001 - v1
Checksum:i5F7DD8B78677E9BF
GO
Isoform 2 (identifier: Q9D0M3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:266
Mass (Da):29,498
Checksum:iA01018037C1561B5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHK1A0A2R8VHK1_MOUSE
Cytochrome c1, heme protein, mitoch...
Cyc1
165Annotation score:
A0A2R8VI32A0A2R8VI32_MOUSE
Cytochrome c1, heme protein, mitoch...
Cyc1
92Annotation score:
A0A2R8VK14A0A2R8VK14_MOUSE
Cytochrome c1, heme protein, mitoch...
Cyc1
30Annotation score:

Sequence cautioni

The sequence AAH82790 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44A → R in BAB22380 (PubMed:16141072).Curated1
Sequence conflicti318K → R in BAB22380 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0250561 – 59Missing in isoform 2. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002815 mRNA Translation: BAB22380.1
AK011288 mRNA Translation: BAB27518.1
AK151299 mRNA Translation: BAE30282.1
AK170272 mRNA Translation: BAE41677.1
BC005620 mRNA Translation: AAH05620.1
BC082790 mRNA Translation: AAH82790.1 Different initiation.
CCDSiCCDS27567.1 [Q9D0M3-1]
RefSeqiNP_079843.1, NM_025567.2 [Q9D0M3-1]
UniGeneiMm.29196

Genome annotation databases

EnsembliENSMUST00000023210; ENSMUSP00000023210; ENSMUSG00000022551 [Q9D0M3-1]
GeneIDi66445
KEGGimmu:66445
UCSCiuc007wjs.1 mouse [Q9D0M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002815 mRNA Translation: BAB22380.1
AK011288 mRNA Translation: BAB27518.1
AK151299 mRNA Translation: BAE30282.1
AK170272 mRNA Translation: BAE41677.1
BC005620 mRNA Translation: AAH05620.1
BC082790 mRNA Translation: AAH82790.1 Different initiation.
CCDSiCCDS27567.1 [Q9D0M3-1]
RefSeqiNP_079843.1, NM_025567.2 [Q9D0M3-1]
UniGeneiMm.29196

3D structure databases

ProteinModelPortaliQ9D0M3
SMRiQ9D0M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211479, 2 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9D0M3
IntActiQ9D0M3, 18 interactors
MINTiQ9D0M3
STRINGi10090.ENSMUSP00000023210

PTM databases

iPTMnetiQ9D0M3
PhosphoSitePlusiQ9D0M3
SwissPalmiQ9D0M3

Proteomic databases

PaxDbiQ9D0M3
PeptideAtlasiQ9D0M3
PRIDEiQ9D0M3
TopDownProteomicsiQ9D0M3-1 [Q9D0M3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023210; ENSMUSP00000023210; ENSMUSG00000022551 [Q9D0M3-1]
GeneIDi66445
KEGGimmu:66445
UCSCiuc007wjs.1 mouse [Q9D0M3-1]

Organism-specific databases

CTDi1537
MGIiMGI:1913695 Cyc1

Phylogenomic databases

eggNOGiKOG3052 Eukaryota
COG2857 LUCA
GeneTreeiENSGT00390000012445
HOGENOMiHOG000003867
HOVERGENiHBG001239
InParanoidiQ9D0M3
KOiK00413
OMAiSRKIAYR
OrthoDBiEOG091G0FT2
PhylomeDBiQ9D0M3
TreeFamiTF314799

Miscellaneous databases

PROiPR:Q9D0M3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022551 Expressed in 297 organ(s), highest expression level in diaphragm
CleanExiMM_CYC1
GenevisibleiQ9D0M3 MM

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002326 Cyt_c1
IPR021157 Cyt_c1_TM_anchor_C
PANTHERiPTHR10266 PTHR10266, 1 hit
PfamiView protein in Pfam
PF02167 Cytochrom_C1, 1 hit
PRINTSiPR00603 CYTOCHROMEC1
SUPFAMiSSF46626 SSF46626, 1 hit
SSF81496 SSF81496, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCY1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0M3
Secondary accession number(s): Q3TDC5
, Q3UAN2, Q63ZW4, Q9DCG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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