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Protein

Cell division cycle-associated protein 7

Gene

Cdca7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity).By similarity1 Publication

Miscellaneous

Transgenic mice overexpress Cdca7 in both T- and B-cell compartments. At 1 year of age, they exhibit elevated incidence of lymphomas, significant increased frequency of solid tumors and a 2-fold increased risk of lymphoid malignancies compared to their littermates.

GO - Biological processi

Keywordsi

Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 7
Gene namesi
Name:Cdca7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914203 Cdca7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493111 – 382Cell division cycle-associated protein 7Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphothreonineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphothreonineCombined sources1
Cross-linki216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei225PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-170 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D0M2
MaxQBiQ9D0M2
PaxDbiQ9D0M2
PeptideAtlasiQ9D0M2
PRIDEiQ9D0M2

PTM databases

iPTMnetiQ9D0M2
PhosphoSitePlusiQ9D0M2

Expressioni

Gene expression databases

BgeeiENSMUSG00000055612 Expressed in 239 organ(s), highest expression level in thymus
CleanExiMM_CDCA7
ExpressionAtlasiQ9D0M2 baseline and differential
GenevisibleiQ9D0M2 MM

Interactioni

Subunit structurei

Interacts with MYC (via C-terminus), YWHAE and YWHAZ.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099752

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 177Interaction with MYCBy similarityAdd BLAST26
Regioni258 – 382Mediates transcriptional activityBy similarityAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi167 – 183Nuclear localization signalBy similarityAdd BLAST17

Phylogenomic databases

eggNOGiENOG410IFJD Eukaryota
ENOG410ZWEA LUCA
GeneTreeiENSGT00390000014657
HOGENOMiHOG000231812
HOVERGENiHBG060300
InParanoidiQ9D0M2
OMAiFKKFRYV
OrthoDBiEOG091G0A11
PhylomeDBiQ9D0M2
TreeFamiTF101076

Family and domain databases

InterProiView protein in InterPro
IPR033576 CDCA7
IPR018866 Znf-4CXXC_R1
PANTHERiPTHR31169:SF2 PTHR31169:SF2, 2 hits
PfamiView protein in Pfam
PF10497 zf-4CXXC_R1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D0M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARRARQKA LKVKNLKDVR YMKLISMETS SSSDDSCDSF ASDNFANTRL
60 70 80 90 100
QLNREGCRTR SQCRHSGPLR VAMKFPARNT RRAASKKAAP PKPSESSAND
110 120 130 140 150
SHSDSEEEEE EEEEEDGMNF LEKRALNIKQ NKAMLAKLMS ELESFPGLFS
160 170 180 190 200
GRHSLPGHRA KDSKSPRRRT FPGVATRRNP ERRTRPLTRS RSRILGSLGA
210 220 230 240 250
LPTEEEEEEE EEEEDKYMLV RQRKSMDSYM NDDDVPRSRR PGSMTLPHII
260 270 280 290 300
RPVEEVTEEE IRNICSNSRE KIYNRSLGST CHQCRQKTTD TKTNCRNPDC
310 320 330 340 350
WGIRGQFCGP CLRNRYGEEV KDALLDPNWH CPPCRGICNC SFCRQRDGRC
360 370 380
ATGVLVYLAK YHGFGNVHAY LKSLKQEFEM QA
Length:382
Mass (Da):43,837
Last modified:June 1, 2001 - v1
Checksum:i51920663588CDD40
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AR39A2AR39_MOUSE
Cell division cycle-associated prot...
Cdca7
192Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → N in BAC26058 (PubMed:16141072).Curated1
Sequence conflicti105S → SE in BAE32269 (PubMed:16141072).Curated1
Sequence conflicti230M → I in BAE39775 (PubMed:16141072).Curated1
Sequence conflicti360K → R in AAH66169 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011289 mRNA Translation: BAB27519.1
AK028671 mRNA Translation: BAC26058.1
AK075882 mRNA Translation: BAC36027.1
AK153943 mRNA Translation: BAE32269.1
AK167734 mRNA Translation: BAE39775.1
BC066169 mRNA Translation: AAH66169.1
CCDSiCCDS16121.1
RefSeqiNP_080142.1, NM_025866.3
UniGeneiMm.270676

Genome annotation databases

EnsembliENSMUST00000102691; ENSMUSP00000099752; ENSMUSG00000055612
GeneIDi66953
KEGGimmu:66953
UCSCiuc008kbx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011289 mRNA Translation: BAB27519.1
AK028671 mRNA Translation: BAC26058.1
AK075882 mRNA Translation: BAC36027.1
AK153943 mRNA Translation: BAE32269.1
AK167734 mRNA Translation: BAE39775.1
BC066169 mRNA Translation: AAH66169.1
CCDSiCCDS16121.1
RefSeqiNP_080142.1, NM_025866.3
UniGeneiMm.270676

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099752

PTM databases

iPTMnetiQ9D0M2
PhosphoSitePlusiQ9D0M2

Proteomic databases

EPDiQ9D0M2
MaxQBiQ9D0M2
PaxDbiQ9D0M2
PeptideAtlasiQ9D0M2
PRIDEiQ9D0M2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102691; ENSMUSP00000099752; ENSMUSG00000055612
GeneIDi66953
KEGGimmu:66953
UCSCiuc008kbx.1 mouse

Organism-specific databases

CTDi83879
MGIiMGI:1914203 Cdca7

Phylogenomic databases

eggNOGiENOG410IFJD Eukaryota
ENOG410ZWEA LUCA
GeneTreeiENSGT00390000014657
HOGENOMiHOG000231812
HOVERGENiHBG060300
InParanoidiQ9D0M2
OMAiFKKFRYV
OrthoDBiEOG091G0A11
PhylomeDBiQ9D0M2
TreeFamiTF101076

Miscellaneous databases

PROiPR:Q9D0M2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055612 Expressed in 239 organ(s), highest expression level in thymus
CleanExiMM_CDCA7
ExpressionAtlasiQ9D0M2 baseline and differential
GenevisibleiQ9D0M2 MM

Family and domain databases

InterProiView protein in InterPro
IPR033576 CDCA7
IPR018866 Znf-4CXXC_R1
PANTHERiPTHR31169:SF2 PTHR31169:SF2, 2 hits
PfamiView protein in Pfam
PF10497 zf-4CXXC_R1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDCA7_MOUSE
AccessioniPrimary (citable) accession number: Q9D0M2
Secondary accession number(s): Q3TIS1
, Q3U511, Q6NZE5, Q8C1A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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